Similar 3D Structures in PDB

The Protein Data Bank (PDB) accession number of structurally similar proteins are listed below, based on the similarity and scoring (highest to lowest) of the BLAST (Basic Local Alignment Search Tool) result. BLAST reference number for the sequence alignment is XXCXZ17D016.

Iteration Number: 1
Query ID: Query_66851
Definition: 2F9Q:A/B/C/D|PDBID|CHAIN|SEQUENCE
Length: 479

Description Total
score		 Query
cover		 E
Value		 Ident Accession
Chain A, Cytochrome P450 2D6 [Homo sapiens] 982 100% 0.0 100% 2F9Q_A
Chain A, Cytochrome P450 2D6 [Homo sapiens] 974 100% 0.0 99% 3QM4_A
Chain A, Cytochrome P450 2D6 [Homo sapiens] 971 100% 0.0 99% 6CSB_A
Chain A, Cytochrome P450 2C8 [Homo sapiens] 388 100% 2e-130 44% 1PQ2_A
Chain A, Cytochrome P450 2B4 [Oryctolagus cuniculus] 383 100% 1e-128 44% 1PO5_A
Chain A, Cytochrome P450 2B4 [Oryctolagus cuniculus] 381 100% 6e-128 44% 1SUO_A
Chain A, Cytochrome P450 2B4 [Oryctolagus cuniculus] 381 100% 9e-128 44% 4MGJ_A
Chain A, Cytochrome P450 2B4 [Oryctolagus cuniculus] 379 100% 4e-127 44% 3TK3_A
Chain A, Cytochrome P450 2B4 [Oryctolagus cuniculus] 374 93% 3e-125 45% 4H1N_A
Chain A, Cytochrome P450 2B4 [Oryctolagus cuniculus] 373 93% 8e-125 45% 2Q6N_A
Chain A, Cytochrome P450 2B4 [Oryctolagus cuniculus] 373 93% 9e-125 45% 6BWW_A
Chain A, Cytochrome P450 2B4 [Oryctolagus cuniculus] 371 93% 8e-124 45% 5IUT_A
Chain A, Cytochrome P450 2C9 [Homo sapiens] 368 100% 1e-122 42% 6VLT_A
Chain A, Cytochrome P450 2C9 [Homo sapiens] 368 100% 1e-122 42% 8VZ7_A
Chain A, Cytochrome P450 2C9 [Homo sapiens] 367 100% 2e-122 42% 5X24_A
Chain A, Cytochrome P450 2C9 [Homo sapiens] 367 100% 2e-122 42% 5X23_A
Chain A, Cytochrome P450 2C9 [Homo sapiens] 367 100% 2e-122 42% 7RL2_A
Chain A, Cytochrome P450 2C19 [Homo sapiens] 366 100% 4e-122 42% 4GQS_A
Chain A, CYTOCHROME P450 2C5 [Oryctolagus cuniculus] 366 100% 5e-122 44% 1DT6_A
Chain A, Cytochrome P450 2E1 [Homo sapiens] 366 100% 7e-122 42% 3E4E_A
Chain A, Cytochrome P450 2C9 [Homo sapiens] 364 100% 2e-121 42% 1R9O_A
Chain A, Cytochrome P450 2A13 [Homo sapiens] 360 100% 1e-119 41% 2P85_A
Chain A, CYTOCHROME P450 2C9 [Homo sapiens] 360 100% 2e-119 42% 1OG2_A
Chain A, Cytochrome P450 2B4 [Oryctolagus cuniculus] 358 92% 9e-119 44% 5EM4_A
Chain A, Cytochrome P450 2C9 [Homo sapiens] 357 99% 2e-118 42% 8VX0_A
Chain A, Cytochrome P450 2A6 [Homo sapiens] 352 100% 1e-116 40% 3EBS_A
Chain A, cytochrome P450, family 2, subfamily A, polypeptide 6 [Homo sapiens] 348 100% 7e-115 39% 1Z10_A
Chain A, Cytochrome P450 2B6 [Homo sapiens] 347 100% 8e-115 43% 3IBD_A
Chain A, Cytochrome P450 2B6 [Homo sapiens] 347 100% 1e-114 43% 5UFG_A
Chain A, Cytochrome P450 2A6 [Homo sapiens] 347 100% 1e-114 39% 2PG7_A
Chain A, Cytochrome P450 2B6 [Homo sapiens] 347 100% 1e-114 43% 4ZV8_A
Chain A, Cytochrome P450 2A6 [Homo sapiens] 347 100% 2e-114 39% 2PG5_A
Chain A, Cytochrome P450 2A6 [Homo sapiens] 345 100% 5e-114 39% 2PG6_A
Chain A, Cytochrome P450 2C9 [Homo sapiens] 342 97% 5e-113 41% 5XXI_A
Chain A, Cytochrome P450 2R1 [Homo sapiens] 337 91% 9e-111 42% 3C6G_A
Chain A, Cytochrome P450 family 2 subfamily B [Neotoma lepida] 335 94% 5e-110 40% 5E0E_A
Chain A, Cytochrome P450 family 2 subfamily B [Neotoma lepida] 335 94% 9e-110 40% 5E58_A
Chain A, Cytochrome P450 2R1 [Homo sapiens] 326 90% 2e-106 41% 3CZH_A
Chain A, Cytochrome P450 1B1 [synthetic construct] 263 92% 1e-81 37% 6OYU_A
Chain A, Cytochrome P450 1B1 [Homo sapiens] 254 99% 2e-78 36% 3PM0_A
Chain A, Cytochrome P450 1A1 [Homo sapiens] 252 93% 1e-77 33% 4I8V_A
Chain A, Cytochrome P450, family 17, subfamily A, polypeptide 1 [Danio rerio] 249 99% 3e-76 31% 6B82_A
Chain A, Cytochrome P450 family 17 polypeptide 2 [Danio rerio] 242 99% 7e-74 33% 4R20_A
Chain A, Cytochrome P450 1B1 [Homo sapiens] 230 91% 1e-69 34% 6IQ5_A
Chain A, Cytochrome P450 1A2 [Homo sapiens] 229 91% 6e-69 33% 2HI4_A
Chain A, Cyp17a1 protein [Danio rerio] 214 87% 9e-64 31% 4R1Z_A
Chain A, Cytochrome P450 21-hydroxylase [Homo sapiens] 200 94% 7e-58 33% 5VBU_A
Chain A, Cytochrome P450 21-hydroxylase [Homo sapiens] 200 94% 7e-58 33% 4Y8W_A
Chain A, Steroid 17-alpha-hydroxylase/17,20 lyase [Homo sapiens] 197 100% 1e-56 28% 4NKV_A
Chain A, Steroid 17-alpha-hydroxylase/17,20 lyase [Homo sapiens] 195 100% 8e-56 27% 3RUK_A
Chain A, Steroid 17-alpha-hydroxylase/17,20 lyase [Homo sapiens] 194 100% 1e-55 28% 6WR1_A
Chain A, Steroid 21-hydroxylase [Bos taurus] 187 90% 4e-53 30% 3QZ1_A
Chain A, Polybrominated aromatic compounds synthase [Marinomonas mediterranea] 139 86% 2e-35 26% 9MS3_A
Chain A, Sugiol synthase [Salvia miltiorrhiza] 139 96% 2e-35 27% 7X2Q_A
Chain A, Ferruginol synthase [Salvia miltiorrhiza] 137 93% 2e-34 26% 5YLW_A
Chain A, Cinnamic acid 4-hydroxylase [Sorghum bicolor] 135 93% 7e-34 26% 6VBY_A
Chain A, Isoflavone synthase 1 [Medicago truncatula] 134 100% 1e-33 26% 8E83_A
Chain A, Cytochrome P450 3A4 [Homo sapiens] 111 97% 9e-26 24% 5VCD_A
Chain A, CYTOCHROME P450 3A4 [Homo sapiens] 110 97% 2e-25 24% 4D6Z_A
Chain A, Cytochrome P450 3A4 [Homo sapiens] 110 97% 2e-25 24% 9YK4_A
Chain A, Cytochrome P450 3A4 [Homo sapiens] 109 97% 4e-25 24% 3TJS_A
Chain A, Cytochrome P450 3A4 [Homo sapiens] 109 97% 4e-25 24% 7LXL_A
Chain A, cytochrome P450 3A4 [Homo sapiens] 109 97% 5e-25 24% 1TQN_A
Chain A, Cytochrome P450 3A4 [Homo sapiens] 109 97% 5e-25 24% 7KVK_A
Chain A, CYTOCHROME P450 3A4 [Homo sapiens] 109 100% 5e-25 24% 1W0E_A
Chain A, Cytochrome P450 3A4 [Homo sapiens] 109 97% 5e-25 23% 6MA7_A
Chain A, Cytochrome P450 3A4 [Homo sapiens] 109 97% 5e-25 24% 4NY4_A
Chain A, Cytochrome P450 3A7 [Homo sapiens] 108 97% 7e-25 24% 8GK3_A
Chain A, Isoform 2 of Cytochrome P450 3A7 [Homo sapiens] 105 90% 1e-23 24% 7MK8_A
Chain A, Cytochrome P450 3A5 [Homo sapiens] 103 97% 3e-23 24% 5VEU_A
Chain A, Cytochrome P450 3A5 [Homo sapiens] 103 97% 4e-23 24% 7LAD_A
Chain A, PUTATIVE CYTOCHROME P450 120 [Synechocystis sp. PCC 6803] 96.7 95% 6e-21 26% 2VE3_A
Chain A, Cytochrome P450 4B1 [Oryctolagus cuniculus] 92.4 40% 2e-19 29% 6C93_A
Chain A, Putative cytochrome P450 [Streptomyces avermitilis] 91.3 72% 5e-19 28% 7WZL_A
Chain A, 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial [Rattus norvegicus] 90.5 39% 9e-19 29% 3K9V_A
Chain A, Cytochrome P450 4B1 [Oryctolagus cuniculus] 90.5 40% 10e-19 29% 5T6Q_A
Chain A, Cholesterol 24-hydroxylase [Homo sapiens] 81.6 38% 6e-16 29% 7LRL_A
Chain A, Cytochrome P450 46A1 [unidentified] 81.3 38% 10e-16 29% 2Q9F_A
Chain A, Taxadiene 5-alpha hydroxylase [Taxus cuspidata] 80.9 87% 10e-16 26% 8X3E_A
Chain A, Taxadiene 5-alpha hydroxylase [Taxus cuspidata] 80.9 87% 1e-15 26% 8X1W_A
Chain A, Bifunctional cytochrome P450/NADPH--P450 reductase [Thermothelomyces thermophilus ATCC 42464] 79.0 41% 4e-15 31% 7P6L_A
Chain A, Carotene epsilon-monooxygenase, chloroplastic [Arabidopsis thaliana] 78.6 43% 7e-15 27% 6L8H_A
Chain A, Protein LUTEIN DEFICIENT 5, chloroplastic [Arabidopsis thaliana] 77.4 40% 2e-14 28% 6J94_A
Chain A, Protein LUTEIN DEFICIENT 5, chloroplastic [Arabidopsis thaliana] 77.0 40% 2e-14 28% 6L8I_A
Chain A, Bifunctional cytochrome P450/NADPH--P450 reductase [Priestia megaterium] 73.2 48% 4e-13 26% 5E9Z_A
Chain A, Bifunctional cytochrome P450/NADPH--P450 reductase [Priestia megaterium] 73.2 48% 5e-13 26% 6IAO_A
Chain A, Bifunctional P-450/NADPH-P450 reductase [Priestia megaterium] 72.4 61% 7e-13 23% 4ZF6_A
Chain A, Bifunctional P-450/NADPH-P450 reductase [Priestia megaterium] 72.0 61% 8e-13 23% 4ZF8_A
Chain A, Bifunctional cytochrome P450/NADPH--P450 reductase [Bacillus cereus] 72.0 92% 8e-13 23% 8HKJ_A
Chain A, Bifunctional P-450:NADPH-P450 reductase [Priestia megaterium] 71.2 48% 2e-12 26% 1ZOA_A
Chain A, Obtusifoliol 14alphademethylase [Acanthamoeba castellanii str. Neff] 70.5 97% 2e-12 24% 6Q2C_A
Chain A, Bifunctional P-450/NADPH-P450 reductase [Priestia megaterium] 70.5 49% 3e-12 26% 4RSN_A
Chain A, Bifunctional cytochrome P450/NADPH--P450 reductase [Priestia megaterium NBRC 15308 = ATCC 14581] 70.1 58% 3e-12 24% 9WMA_A
Chain A, Bifunctional cytochrome P450/NADPH--P450 reductase [Priestia megaterium NBRC 15308 = ATCC 14581] 69.7 48% 4e-12 25% 7Y9J_A
Chain A, Bifunctional P-450/NADPH-P450 reductase [Priestia megaterium] 69.7 41% 5e-12 26% 4HGG_A
Chain A, Bifunctional P-450/NADPH-P450 reductase [Priestia megaterium] 69.7 41% 5e-12 26% 4HGF_A
Chain A, Bifunctional P-450/NADPH-P450 reductase [Priestia megaterium] 69.7 41% 5e-12 26% 4HGH_A
Chain A, CYTOCHROME P450 BM-3 [Priestia megaterium] 69.3 48% 5e-12 25% 1FAG_A
Chain A, Bifunctional cytochrome P450/NADPH--P450 reductase [Priestia megaterium] 69.3 49% 5e-12 25% 9L7V_A
Chain A, Bifunctional cytochrome P450/NADPH--P450 reductase [Priestia megaterium] 69.3 49% 5e-12 25% 5OG9_A

Hit Number: 1, Accession Number: 2F9Q_A
pdb|2F9Q|A Chain A, Cytochrome P450 2D6 [Homo sapiens]
Length = 479, Score = 982 bits (2538), Expect = 0.0,
Identities = 479/479 (100%), Positives = 479/479 (100%), Gaps = 0/479 (0%)
Query  1    MAKKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLN  60
            MAKKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLN
Sbjct  1    MAKKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLN  60

Query  61   GLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNL  120
            GLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNL
Sbjct  61   GLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNL  120

Query  121  GLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRF  180
            GLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRF
Sbjct  121  GLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRF  180

Query  181  LRLLDLAQEGLKEESGFLREVLNAVPVDRHIPALAGKVLRFQKAFLTQLDELLTEHRMTW  240
            LRLLDLAQEGLKEESGFLREVLNAVPVDRHIPALAGKVLRFQKAFLTQLDELLTEHRMTW
Sbjct  181  LRLLDLAQEGLKEESGFLREVLNAVPVDRHIPALAGKVLRFQKAFLTQLDELLTEHRMTW  240

Query  241  DPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMI  300
            DPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMI
Sbjct  241  DPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMI  300

Query  301  LHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRDI  360
            LHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRDI
Sbjct  301  LHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRDI  360

Query  361  EVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRA  420
            EVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRA
Sbjct  361  EVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRA  420

Query  421  CLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPRHHHH  479
            CLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPRHHHH
Sbjct  421  CLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPRHHHH  479

Hit Number: 2, Accession Number: 3QM4_A
pdb|3QM4|A Chain A, Cytochrome P450 2D6 [Homo sapiens]
Length = 479, Score = 974 bits (2517), Expect = 0.0,
Identities = 476/479 (99%), Positives = 477/479 (100%), Gaps = 0/479 (0%)
Query  1    MAKKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLN  60
            MAKKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLN
Sbjct  1    MAKKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLN  60

Query  61   GLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNL  120
            GLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNL
Sbjct  61   GLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNL  120

Query  121  GLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRF  180
            GLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRF
Sbjct  121  GLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRF  180

Query  181  LRLLDLAQEGLKEESGFLREVLNAVPVDRHIPALAGKVLRFQKAFLTQLDELLTEHRMTW  240
            LRLLDLAQEGLKEESGFLREVLNAVPV  HIPALAGKVLRFQKAFLTQLDELLTEHRMTW
Sbjct  181  LRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTW  240

Query  241  DPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMI  300
            DPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMI
Sbjct  241  DPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMI  300

Query  301  LHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRDI  360
            LHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLG+THMTSRDI
Sbjct  301  LHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDI  360

Query  361  EVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRA  420
            EVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRA
Sbjct  361  EVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRA  420

Query  421  CLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPRHHHH  479
            CLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPRHHHH
Sbjct  421  CLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPRHHHH  479

Hit Number: 3, Accession Number: 6CSB_A
pdb|6CSB|A Chain A, Cytochrome P450 2D6 [Homo sapiens]
Length = 479, Score = 971 bits (2510), Expect = 0.0,
Identities = 475/479 (99%), Positives = 476/479 (99%), Gaps = 0/479 (0%)
Query  1    MAKKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLN  60
            MAKKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLN
Sbjct  1    MAKKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLN  60

Query  61   GLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNL  120
            GLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNL
Sbjct  61   GLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNL  120

Query  121  GLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRF  180
            GLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRF
Sbjct  121  GLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRF  180

Query  181  LRLLDLAQEGLKEESGFLREVLNAVPVDRHIPALAGKVLRFQKAFLTQLDELLTEHRMTW  240
            LRLLDLAQEGLKEESGFLREVLNAVPV  HIPALAGKVLRFQKAFLTQLDELLTEHRMTW
Sbjct  181  LRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTW  240

Query  241  DPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMI  300
            DPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGM TTSTTLAWGLLLMI
Sbjct  241  DPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMETTSTTLAWGLLLMI  300

Query  301  LHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRDI  360
            LHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLG+THMTSRDI
Sbjct  301  LHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDI  360

Query  361  EVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRA  420
            EVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRA
Sbjct  361  EVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRA  420

Query  421  CLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPRHHHH  479
            CLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPRHHHH
Sbjct  421  CLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPRHHHH  479

Hit Number: 4, Accession Number: 1PQ2_A
pdb|1PQ2|A Chain A, Cytochrome P450 2C8 [Homo sapiens]
Length = 476, Score = 388 bits (996), Expect = 2e-130,
Identities = 211/481 (44%), Positives = 293/481 (61%), Gaps = 7/481 (1%)
Query  1    MAKKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLN  60
            MAKKTSSKGKLPPGP PLP +GN+L +D ++    F    + +G VF++     P+VV +
Sbjct  1    MAKKTSSKGKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFH  60

Query  61   GLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNL  120
            G  AV+EAL+ +GE+ + R   PI+Q +  G    G+ ++  G  W+E RRFS++TLRN 
Sbjct  61   GYEAVKEALIDNGEEFSGRGNSPISQRITKG---LGI-ISSNGKRWKEIRRFSLTTLRNF  116

Query  121  GLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRF  180
            G+GK+S+E  V EEA CL          P  P  +L  A  NVI S+   +RF+Y D  F
Sbjct  117  GMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNF  176

Query  181  LRLLDLAQEGLKEESGFLREVLNAVPV-DRHIPALAGKVLRFQKAFLTQLDELLTEHRMT  239
            L L+    E  +  +    +V N  P+     P    KVL+      + + E + EH+ +
Sbjct  177  LTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQAS  236

Query  240  WDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLM  299
             D    PRD  + FL +ME+ K N +S FN ENL   VADLF AG  TTSTTL +GLLL+
Sbjct  237  LD-VNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLL  295

Query  300  ILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRD  359
            + HP+V  +VQ+EID VIG+ R P M D++HMPYT AV+HE+QR+ D+VP G+ H  + D
Sbjct  296  LKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTD  355

Query  360  IEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRR  419
             + + + IPKGTT++  L+SVL D+  +  P  F P HFLD  G+F K + F+PFSAG+R
Sbjct  356  TKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKR  415

Query  420  ACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVS-PSPYELCAVPRHHH  478
             C GE LARMELFLF T++LQ+F+          +   V   +VS P  Y++C +P HHH
Sbjct  416  ICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQICFIPVHHH  475

Query  479  H  479
            H
Sbjct  476  H  476

Hit Number: 5, Accession Number: 1PO5_A
pdb|1PO5|A Chain A, Cytochrome P450 2B4 [Oryctolagus cuniculus]
Length = 476, Score = 383 bits (983), Expect = 1e-128,
Identities = 215/486 (44%), Positives = 287/486 (59%), Gaps = 17/486 (3%)
Query  1    MAKKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLN  60
            MAKKTSSKGKLPPGP PLP LGNLL +D +     F +LR ++GDVF++ L   PVVVL 
Sbjct  1    MAKKTSSKGKLPPGPSPLPVLGNLLQMDRKGLLRSFLRLREKYGDVFTVYLGSRPVVVLC  60

Query  61   GLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNL  120
            G  A+REALV   E  + R  + +   +  G    GV  A  G  WR  RRFS++T+R+ 
Sbjct  61   GTDAIREALVDQAEAFSGRGKIAVVDPIFQG---YGVIFAN-GERWRALRRFSLATMRDF  116

Query  121  GLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRF  180
            G+GK+S+E+ + EEA CL        G       L     SN+I S+  G+RF+Y DP F
Sbjct  117  GMGKRSVEERIQEEARCLVEELRKSKGALLDNTLLFHSITSNIICSIVFGKRFDYKDPVF  176

Query  181  LRLLDLAQEGLKEESGFLREVLNAVP-VDRHIPALAGKVLRFQKAFLTQLDELLTEHRMT  239
            LRLLDL  +     S F  +V        +H P    ++ R  +   T + + + +HR T
Sbjct  177  LRLLDLFFQSFSLISSFSSQVFELFSGFLKHFPGTHRQIYRNLQEINTFIGQSVEKHRAT  236

Query  240  WDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLM  299
             DP+ P RD  + +L  MEK K +P S F+ +NL + V  LF AG  TTSTTL +G LLM
Sbjct  237  LDPSNP-RDFIDVYLLRMEKDKSDPSSEFHHQNLILTVLSLFFAGTETTSTTLRYGFLLM  295

Query  300  ILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRD  359
            + +P V  RVQ+EI+ VIG  R P + D+A MPYT AVIHE+QR GD++P G+ H  ++D
Sbjct  296  LKYPHVTERVQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPHTVTKD  355

Query  360  IEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRR  419
             + +G+ IPK T +   LSS L D   +E P  F+P HFLDA G   + E F+PFS G+R
Sbjct  356  TQFRGYVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGALKRNEGFMPFSLGKR  415

Query  420  ACLGEPLARMELFLFFTSLLQHFSFSVPTG------QPRPSHHGVFAFLVSPSPYELCAV  473
             CLGE +AR ELFLFFT++LQ+FS + P         PR S  G       P  Y++  +
Sbjct  416  ICLGEGIARTELFLFFTTILQNFSIASPVPPEDIDLTPRESGVGNV-----PPSYQIRFL  470

Query  474  PRHHHH  479
             RHHHH
Sbjct  471  ARHHHH  476

Hit Number: 6, Accession Number: 1SUO_A
pdb|1SUO|A Chain A, Cytochrome P450 2B4 [Oryctolagus cuniculus]
Length = 476, Score = 381 bits (979), Expect = 6e-128,
Identities = 214/486 (44%), Positives = 287/486 (59%), Gaps = 17/486 (3%)
Query  1    MAKKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLN  60
            MAKKTSSKGKLPPGP PLP LGNLL +D +     F +LR ++GDVF++ L   PVVVL 
Sbjct  1    MAKKTSSKGKLPPGPSPLPVLGNLLQMDRKGLLRSFLRLREKYGDVFTVYLGSRPVVVLC  60

Query  61   GLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNL  120
            G  A+REALV   E  + R  + +   +  G    GV  A  G  WR  RRFS++T+R+ 
Sbjct  61   GTDAIREALVDQAEAFSGRGKIAVVDPIFQG---YGVIFAN-GERWRALRRFSLATMRDF  116

Query  121  GLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRF  180
            G+GK+S+E+ + EEA CL        G       L     SN+I S+  G+RF+Y DP F
Sbjct  117  GMGKRSVEERIQEEARCLVEELRKSKGALLDNTLLFHSITSNIICSIVFGKRFDYKDPVF  176

Query  181  LRLLDLAQEGLKEESGFLREVLNAVP-VDRHIPALAGKVLRFQKAFLTQLDELLTEHRMT  239
            LRLLDL  +     S F  +V        ++ P    ++ R  +   T + + + +HR T
Sbjct  177  LRLLDLFFQSFSLISSFSSQVFELFSGFLKYFPGTHRQIYRNLQEINTFIGQSVEKHRAT  236

Query  240  WDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLM  299
             DP+ P RD  + +L  MEK K +P S F+ +NL + V  LF AG  TTSTTL +G LLM
Sbjct  237  LDPSNP-RDFIDVYLLRMEKDKSDPSSEFHHQNLILTVLSLFFAGTETTSTTLRYGFLLM  295

Query  300  ILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRD  359
            + +P V  RVQ+EI+ VIG  R P + D+A MPYT AVIHE+QR GD++P G+ H  ++D
Sbjct  296  LKYPHVTERVQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPHTVTKD  355

Query  360  IEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRR  419
             + +G+ IPK T +   LSS L D   +E P  F+P HFLDA G   + E F+PFS G+R
Sbjct  356  TQFRGYVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGALKRNEGFMPFSLGKR  415

Query  420  ACLGEPLARMELFLFFTSLLQHFSFSVPTG------QPRPSHHGVFAFLVSPSPYELCAV  473
             CLGE +AR ELFLFFT++LQ+FS + P         PR S  G       P  Y++  +
Sbjct  416  ICLGEGIARTELFLFFTTILQNFSIASPVPPEDIDLTPRESGVGNV-----PPSYQIRFL  470

Query  474  PRHHHH  479
             RHHHH
Sbjct  471  ARHHHH  476

Hit Number: 7, Accession Number: 4MGJ_A
pdb|4MGJ|A Chain A, Cytochrome P450 2B4 [Oryctolagus cuniculus]
Length = 476, Score = 381 bits (978), Expect = 9e-128,
Identities = 214/486 (44%), Positives = 287/486 (59%), Gaps = 17/486 (3%)
Query  1    MAKKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLN  60
            MAKKTSSKGKLPPGP PLP LGNLL +D +     F +LR ++GDVF++ L   PVVVL 
Sbjct  1    MAKKTSSKGKLPPGPSPLPVLGNLLQMDRKGLLRSFLRLREKYGDVFTVYLGSRPVVVLC  60

Query  61   GLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNL  120
            G  A+REALV   E  + R  + +   +  G    GV  A  G  WR  RRFS++T+R+ 
Sbjct  61   GTDAIREALVDQAEAFSGRGKIAVVDPIFQG---YGVIFAN-GERWRALRRFSLATMRDF  116

Query  121  GLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRF  180
            G+GK+S+E+ + EEA CL        G       L     SN+I S+  G+RF+Y DP F
Sbjct  117  GMGKRSVEERIQEEARCLVEELRKSKGALLDNTLLFHSITSNIICSIVFGKRFDYKDPVF  176

Query  181  LRLLDLAQEGLKEESGFLREVLNAVP-VDRHIPALAGKVLRFQKAFLTQLDELLTEHRMT  239
            LRLLDL  +     S F  +V    P   ++ P    ++ R  +   T + + + +HR T
Sbjct  177  LRLLDLFFQSFSLISSFSSQVFELFPGFLKYFPGTHRQIYRNLQEINTFIGQSVEKHRAT  236

Query  240  WDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLM  299
             DP+ P RD  + +L  MEK K +P S F+ +NL + V  LF AG  TTSTTL +G LLM
Sbjct  237  LDPSNP-RDFIDVYLLRMEKDKSDPSSEFHHQNLILTVLSLFFAGTETTSTTLRYGFLLM  295

Query  300  ILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRD  359
            + +P V  RVQ+EI+ VIG  R P + D+A MPYT AVIHE+QR GD++P G+ H  ++D
Sbjct  296  LKYPHVTERVQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPHTVTKD  355

Query  360  IEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRR  419
             + +G+ IPK T +   LSS L D   +E P  F+P HFLDA G   + E F+P S G+R
Sbjct  356  TQFRGYVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGALKRNEGFMPHSLGKR  415

Query  420  ACLGEPLARMELFLFFTSLLQHFSFSVPTG------QPRPSHHGVFAFLVSPSPYELCAV  473
             CLGE +AR ELFLFFT++LQ+FS + P         PR S  G       P  Y++  +
Sbjct  416  ICLGEGIARTELFLFFTTILQNFSIASPVPPEDIDLTPRESGVGNV-----PPSYQIRFL  470

Query  474  PRHHHH  479
             RHHHH
Sbjct  471  ARHHHH  476

Hit Number: 8, Accession Number: 3TK3_A
pdb|3TK3|A Chain A, Cytochrome P450 2B4 [Oryctolagus cuniculus]
Length = 476, Score = 379 bits (973), Expect = 4e-127,
Identities = 213/486 (44%), Positives = 286/486 (59%), Gaps = 17/486 (3%)
Query  1    MAKKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLN  60
            MAKKTSSKGKLPPGP PLP LGNLL +D +     F +LR ++GDVF++ L   PVVVL 
Sbjct  1    MAKKTSSKGKLPPGPSPLPVLGNLLQMDRKGLLRSFLRLREKYGDVFTVYLGSRPVVVLC  60

Query  61   GLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNL  120
            G  A+REALV   E  + R  + +   +  G    GV  A  G  WR  RRFS++T+R+ 
Sbjct  61   GTDAIREALVDQAEAFSGRGKIAVVDPIFQG---YGVIFAN-GERWRALRRFSLATMRDF  116

Query  121  GLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRF  180
            G+GK+S+E+ + EEA CL        G       L     SN+I S+  G+RF+Y DP F
Sbjct  117  GMGKRSVEERIQEEARCLVEELRKSKGALLDNTLLFHSITSNIICSIVFGKRFDYKDPVF  176

Query  181  LRLLDLAQEGLKEESGFLREVLNAVP-VDRHIPALAGKVLRFQKAFLTQLDELLTEHRMT  239
            LRLLDL  +     S F  +V        ++ P    ++ R  +   T + + + +HR T
Sbjct  177  LRLLDLFFQSFSLISSFSSQVFELFSGFLKYFPGTHRQIYRNLQEINTFIGQSVEKHRAT  236

Query  240  WDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLM  299
             DP+ P RD  + +L  MEK K +P S F+ +NL + V  LF AG  TTSTTL +G LLM
Sbjct  237  LDPSNP-RDFIDVYLLRMEKDKSDPSSEFHHQNLILTVLSLFFAGTETTSTTLRYGFLLM  295

Query  300  ILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRD  359
            + +P V  RVQ+EI+ VIG  R P + D+A MPYT AVIHE+QR GD++P G+ H  ++D
Sbjct  296  LKYPHVTERVQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPHTVTKD  355

Query  360  IEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRR  419
             + +G+ IPK T +   LSS L D   +E P  F+P HFLDA G   + E F+PFS G+R
Sbjct  356  TQFRGYVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGALKRNEGFMPFSLGKR  415

Query  420  ACLGEPLARMELFLFFTSLLQHFSFSVPTG------QPRPSHHGVFAFLVSPSPYELCAV  473
             C GE +AR ELFLFFT++LQ+FS + P         PR S  G       P  Y++  +
Sbjct  416  ICAGEGIARTELFLFFTTILQNFSIASPVPPEDIDLTPRESGVGNV-----PPSYQIRFL  470

Query  474  PRHHHH  479
             RHHHH
Sbjct  471  ARHHHH  476

Hit Number: 9, Accession Number: 4H1N_A
pdb|4H1N|A Chain A, Cytochrome P450 2B4 [Oryctolagus cuniculus]
Length = 479, Score = 374 bits (961), Expect = 3e-125,
Identities = 203/449 (45%), Positives = 274/449 (61%), Gaps = 6/449 (1%)
Query  1    MAKKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLN  60
            MAKKTSSKGKLPPGP PLP LGNLL +D +     F +LR ++GDVF++ L   PVVVL 
Sbjct  1    MAKKTSSKGKLPPGPSPLPVLGNLLQMDRKGLLRSFLRLREKYGDVFTVYLGSRPVVVLC  60

Query  61   GLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNL  120
            G  A+REALV   E  + R  + +   +  G    GV  A  G  WR  RRFS++T+R+ 
Sbjct  61   GTDAIREALVDQAEAFSGRGKIAVVDPIFQG---YGVIFAN-GERWRALRRFSLATMRDF  116

Query  121  GLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRF  180
            G+GK+S+E+ + EEA CL        G       L     SN+I S+  G+RF+Y DP F
Sbjct  117  GMGKRSVEERIQEEARCLVEELRKSKGALLDNTLLFHSITSNIICSIVFGKRFDYKDPVF  176

Query  181  LRLLDLAQEGLKEESGFLREVLNAVP-VDRHIPALAGKVLRFQKAFLTQLDELLTEHRMT  239
            LRLLDL  +     S F  +V        ++ P    ++ R  +   T + + + +HR T
Sbjct  177  LRLLDLFFQSFSLISSFSSQVFELFSGFLKYFPGTHRQIYRNLQEINTFIGQSVEKHRAT  236

Query  240  WDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLM  299
             DP+ P RD  + +L  MEK K +P S F+ +NL + V  LF+AG  TTSTTL +G LLM
Sbjct  237  LDPSNP-RDFIDVYLLRMEKDKSDPSSEFHHQNLILTVLSLFAAGTETTSTTLRYGFLLM  295

Query  300  ILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRD  359
            + +P V  RVQ+EI+ VIG  R P + D+A MPYT AVIHE+QR GD++P G+ H  ++D
Sbjct  296  LKYPHVTERVQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPHTVTKD  355

Query  360  IEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRR  419
             + +G+ IPK T +   LSS L D   +E P  F+P HFLDA G   + E F+PFS G+R
Sbjct  356  TQFRGYVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGALKRNEGFMPFSLGKR  415

Query  420  ACLGEPLARMELFLFFTSLLQHFSFSVPT  448
             CLGE +AR ELFLFFT++LQ+FS + P 
Sbjct  416  ICLGEGIARTELFLFFTTILQNFSIASPV  444

Hit Number: 10, Accession Number: 2Q6N_A
pdb|2Q6N|A Chain A, Cytochrome P450 2B4 [Oryctolagus cuniculus]
Length = 478, Score = 373 bits (958), Expect = 8e-125,
Identities = 203/449 (45%), Positives = 273/449 (61%), Gaps = 6/449 (1%)
Query  1    MAKKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLN  60
            MAKKTSSKGKLPPGP PLP LGNLL +D +     F +LR ++GDVF++ L   PVVVL 
Sbjct  1    MAKKTSSKGKLPPGPSPLPVLGNLLQMDRKGLLRSFLRLREKYGDVFTVYLGSRPVVVLC  60

Query  61   GLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNL  120
            G  A+REALV   E  + R  + +   +  G    GV  A  G  WR  RRFS++T+R+ 
Sbjct  61   GTDAIREALVDQAEAFSGRGKIAVVDPIFQG---YGVIFAN-GERWRALRRFSLATMRDF  116

Query  121  GLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRF  180
            G+GK+S+E+ + EEA CL        G       L     SN+I S+  G+RF+Y DP F
Sbjct  117  GMGKRSVEERIQEEARCLVEELRKSKGALLDNTLLFHSITSNIICSIVFGKRFDYKDPVF  176

Query  181  LRLLDLAQEGLKEESGFLREVLNAVP-VDRHIPALAGKVLRFQKAFLTQLDELLTEHRMT  239
            LRLLDL  +     S F  +V        ++ P    ++ R  +   T + + + +HR T
Sbjct  177  LRLLDLFFQSFSLISSFSSQVFELFSGFLKYFPGTHRQIYRNLQEINTFIGQSVEKHRAT  236

Query  240  WDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLM  299
             DP+ P RD  + +L  MEK K +P S F+ +NL + V  LF AG  TTSTTL +G LLM
Sbjct  237  LDPSNP-RDFIDVYLLRMEKDKSDPSSEFHHQNLILTVLSLFFAGTETTSTTLRYGFLLM  295

Query  300  ILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRD  359
            + +P V  RVQ+EI+ VIG  R P + D+A MPYT AVIHE+QR GD++P G+ H  ++D
Sbjct  296  LKYPHVTERVQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPHTVTKD  355

Query  360  IEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRR  419
             + +G+ IPK T +   LSS L D   +E P  F+P HFLDA G   + E F+PFS G+R
Sbjct  356  TQFRGYVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGALKRNEGFMPFSLGKR  415

Query  420  ACLGEPLARMELFLFFTSLLQHFSFSVPT  448
             CLGE +AR ELFLFFT++LQ+FS + P 
Sbjct  416  ICLGEGIARTELFLFFTTILQNFSIASPV  444

Hit Number: 11, Accession Number: 6BWW_A
pdb|6BWW|A Chain A, Cytochrome P450 2B4 [Oryctolagus cuniculus]
Length = 472, Score = 373 bits (957), Expect = 9e-125,
Identities = 203/449 (45%), Positives = 273/449 (61%), Gaps = 6/449 (1%)
Query  1    MAKKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLN  60
            MAKKTSSKGKLPPGP PLP LGNLL +D +     F +LR ++GDVF++ L   PVVVL 
Sbjct  1    MAKKTSSKGKLPPGPSPLPVLGNLLQMDRKGLLRSFLRLREKYGDVFTVYLGSRPVVVLC  60

Query  61   GLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNL  120
            G  A+REALV   E  + R  + +   +  G    GV  A  G  WR  RRFS++T+R+ 
Sbjct  61   GTDAIREALVDQAEAFSGRGKIAVVDPIFQG---YGVIFAN-GERWRALRRFSLATMRDF  116

Query  121  GLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRF  180
            G+GK+S+E+ + EEA CL        G       L     SN+I S+  G+RF+Y DP F
Sbjct  117  GMGKRSVEERIQEEARCLVEELRKSKGALLDNTLLFHSITSNIICSIVFGKRFDYKDPVF  176

Query  181  LRLLDLAQEGLKEESGFLREVLNAVP-VDRHIPALAGKVLRFQKAFLTQLDELLTEHRMT  239
            LRLLDL  +     S F  +V    P   ++ P    ++ R  +   T + + + +HR T
Sbjct  177  LRLLDLFFQSFSLISSFSSQVFELFPGFLKYFPGTHRQIYRNLQEINTFIGQSVEKHRAT  236

Query  240  WDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLM  299
             DP+ P RD  + +L  MEK K +P S F+ +NL + V  LF AG  TTSTTL +G LLM
Sbjct  237  LDPSNP-RDFIDVYLLRMEKDKSDPSSEFHHQNLILTVLSLFFAGTETTSTTLRYGFLLM  295

Query  300  ILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRD  359
            + +P V  RVQ+EI+ VIG  R P + D+A MPYT AVIHE+QR GD++P G+ H  ++D
Sbjct  296  LKYPHVTERVQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPHTVTKD  355

Query  360  IEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRR  419
             + +G+ IPK T +   LSS L D   +E P  F+P HFLDA G   + E F+P S G+R
Sbjct  356  TQFRGYVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGALKRNEGFMPHSLGKR  415

Query  420  ACLGEPLARMELFLFFTSLLQHFSFSVPT  448
             CLGE +AR ELFLFFT++LQ+FS + P 
Sbjct  416  ICLGEGIARTELFLFFTTILQNFSIASPV  444

Hit Number: 12, Accession Number: 5IUT_A
pdb|5IUT|A Chain A, Cytochrome P450 2B4 [Oryctolagus cuniculus]
Length = 478, Score = 371 bits (952), Expect = 8e-124,
Identities = 203/449 (45%), Positives = 273/449 (61%), Gaps = 6/449 (1%)
Query  1    MAKKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLN  60
            MAKKTSSKGKLPPGP PLP LGNLL +D +     F +LR ++GDVF++ L   PVVVL 
Sbjct  1    MAKKTSSKGKLPPGPSPLPVLGNLLQMDRKGLLRSFLRLREKYGDVFTVYLGSRPVVVLC  60

Query  61   GLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNL  120
            G  A+REALV   E  + R  + +   +  G    GV  A  G  WR  RRFS++T+R+ 
Sbjct  61   GTDAIREALVDQAEAFSGRGKIAVVDPIFQG---YGVIFAN-GERWRALRRFSLATMRDF  116

Query  121  GLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRF  180
            G+GK+S+E+ + EEA CL        G       L     SN+I S+  G+RF+Y DP F
Sbjct  117  GMGKRSVEERIQEEARCLVEELRKSKGALLDNTLLFHSITSNIICSIVFGKRFDYKDPVF  176

Query  181  LRLLDLAQEGLKEESGFLREVLNAVP-VDRHIPALAGKVLRFQKAFLTQLDELLTEHRMT  239
            LRLLDL  +     S F  +V        ++ P    ++ R  +   T + + + +HR T
Sbjct  177  LRLLDLWFQSFSLISSFSSQVFELFSGFLKYFPGTHRQIYRNLQEINTFIGQSVEKHRAT  236

Query  240  WDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLM  299
             DP+ P RD  + +L  MEK K +P S F+ +NL + V  LF AG  TTSTTL +G LLM
Sbjct  237  LDPSNP-RDFIDVYLLRMEKDKSDPSSEFHHQNLILTVLSLFFAGTETTSTTLRYGFLLM  295

Query  300  ILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRD  359
            + +P V  RVQ+EI+ VIG  R P + D+A MPYT AVIHE+QR GD++P G+ H  ++D
Sbjct  296  LKYPHVTERVQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPHTVTKD  355

Query  360  IEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRR  419
             + +G+ IPK T +   LSS L D   +E P  F+P HFLDA G   + E F+PFS G+R
Sbjct  356  TQFRGYVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGALKRNEGFMPFSLGKR  415

Query  420  ACLGEPLARMELFLFFTSLLQHFSFSVPT  448
             CLGE +AR ELFLFFT++LQ+FS + P 
Sbjct  416  ICLGEGIARTELFLFFTTILQNFSIASPV  444

Hit Number: 13, Accession Number: 6VLT_A
pdb|6VLT|A Chain A, Cytochrome P450 2C9 [Homo sapiens]
Length = 476, Score = 368 bits (944), Expect = 1e-122,
Identities = 203/481 (42%), Positives = 288/481 (60%), Gaps = 7/481 (1%)
Query  1    MAKKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLN  60
            MAKKTS +GKLPPGP PLP +GN+L +  ++       L + +G VF+L     P+VVL+
Sbjct  1    MAKKTSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLH  60

Query  61   GLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNL  120
            G  AV+EAL+  GE+ + R   P+ +      R  G+  +  G  W+E RRFS+ TLRN 
Sbjct  61   GYEAVKEALIDLGEEFSGRGIFPLAERAN---RGFGIVFSN-GKKWKEIRRFSLMTLRNF  116

Query  121  GLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRF  180
            G+GK+S+E  V EEA CL          P  P  +L  A  NVI S+   +RF+Y D +F
Sbjct  117  GMGKRSIEDCVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQF  176

Query  181  LRLLDLAQEGLKE-ESGFLREVLNAVPVDRHIPALAGKVLRFQKAFLTQLDELLTEHRMT  239
            L L++   E +K   S +++   N  P+  + P    K+L+      + + E + EH+ +
Sbjct  177  LNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQES  236

Query  240  WDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLM  299
             D    P+D  + FL +MEK K N  S F  E+L     DLF AG  TTSTTL + LLL+
Sbjct  237  MD-MNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLL  295

Query  300  ILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRD  359
            + HP+V  +VQ+EI+ VIG+ R P M D++HMPYT AV+HEVQR+ D++P  + H  + D
Sbjct  296  LKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCD  355

Query  360  IEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRR  419
            I+ + + IPKGTT++ +L+SVL D   +  P  F P HFLD  G+F K + F+PFSAG+R
Sbjct  356  IKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKR  415

Query  420  ACLGEPLARMELFLFFTSLLQHFSF-SVPTGQPRPSHHGVFAFLVSPSPYELCAVPRHHH  478
             C+GE LA MELFLF TS+LQ+F+  S+   +   +   V  F   P  Y+LC +P HHH
Sbjct  416  ICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIPIHHH  475

Query  479  H  479
            H
Sbjct  476  H  476

Hit Number: 14, Accession Number: 8VZ7_A
pdb|8VZ7|A Chain A, Cytochrome P450 2C9 [Homo sapiens]
Length = 476, Score = 368 bits (944), Expect = 1e-122,
Identities = 203/481 (42%), Positives = 288/481 (60%), Gaps = 7/481 (1%)
Query  1    MAKKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLN  60
            MAKKTS +GKLPPGP PLP +GN+L +  ++       L + +G VF+L     P+VVL+
Sbjct  1    MAKKTSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLH  60

Query  61   GLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNL  120
            G  AV+EAL+  GE+ + R   P+ +      R  G+  +  G  W+E RRFS+ TLRN 
Sbjct  61   GYEAVKEALIDLGEEFSGRGIFPLAERAN---RGFGIVFSN-GKKWKEIRRFSLMTLRNF  116

Query  121  GLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRF  180
            G+GK+S+E  V EEA CL          P  P  +L  A  NVI S+   +RF+Y D +F
Sbjct  117  GMGKRSIEDRVQEEALCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQF  176

Query  181  LRLLDLAQEGLKE-ESGFLREVLNAVPVDRHIPALAGKVLRFQKAFLTQLDELLTEHRMT  239
            L L++   E +K   S +++   N  P+  + P    K+L+      + + E + EH+ +
Sbjct  177  LNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQES  236

Query  240  WDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLM  299
             D    P+D  + FL +MEK K N  S F  E+L     DLF AG  TTSTTL + LLL+
Sbjct  237  MD-MNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLL  295

Query  300  ILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRD  359
            + HP+V  +VQ+EI+ VIG+ R P M D++HMPYT AV+HEVQR+ D++P  + H  + D
Sbjct  296  LKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCD  355

Query  360  IEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRR  419
            I+ + + IPKGTT++ +L+SVL D   +  P  F P HFLD  G+F K + F+PFSAG+R
Sbjct  356  IKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKR  415

Query  420  ACLGEPLARMELFLFFTSLLQHFSF-SVPTGQPRPSHHGVFAFLVSPSPYELCAVPRHHH  478
             C+GE LA MELFLF TS+LQ+F+  S+   +   +   V  F   P  Y+LC +P HHH
Sbjct  416  ICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIPIHHH  475

Query  479  H  479
            H
Sbjct  476  H  476

Hit Number: 15, Accession Number: 5X24_A
pdb|5X24|A Chain A, Cytochrome P450 2C9 [Homo sapiens]
Length = 476, Score = 367 bits (943), Expect = 2e-122,
Identities = 203/481 (42%), Positives = 288/481 (60%), Gaps = 7/481 (1%)
Query  1    MAKKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLN  60
            MAKKTS +GKLPPGP PLP +GN+L +  ++       L + +G VF+L     P+VVL+
Sbjct  1    MAKKTSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLH  60

Query  61   GLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNL  120
            G  AV+EAL+  GE+ + R   P+ +      R  G+  +  G  W+E RRFS+ TLRN 
Sbjct  61   GYEAVKEALIDLGEEFSGRGIFPLAERAN---RGFGIVFSN-GKKWKEIRRFSLMTLRNF  116

Query  121  GLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRF  180
            G+GK+S+E  V EEA CL          P  P  +L  A  NVI S+   +RF+Y D +F
Sbjct  117  GMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQF  176

Query  181  LRLLDLAQEGLKE-ESGFLREVLNAVPVDRHIPALAGKVLRFQKAFLTQLDELLTEHRMT  239
            L L++   E +K   S +++   N  P+  + P    K+L+      + + E + EH+ +
Sbjct  177  LNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQES  236

Query  240  WDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLM  299
             D    P+D  + FL +MEK K N  S F  E+L     DLF AG  TTSTTL + LLL+
Sbjct  237  MD-MNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLL  295

Query  300  ILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRD  359
            + HP+V  +VQ+EI+ VIG+ R P M D++HMPYT AV+HEVQR+ D++P  + H  + D
Sbjct  296  LKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYLDLLPTSLPHAVTCD  355

Query  360  IEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRR  419
            I+ + + IPKGTT++ +L+SVL D   +  P  F P HFLD  G+F K + F+PFSAG+R
Sbjct  356  IKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKR  415

Query  420  ACLGEPLARMELFLFFTSLLQHFSF-SVPTGQPRPSHHGVFAFLVSPSPYELCAVPRHHH  478
             C+GE LA MELFLF TS+LQ+F+  S+   +   +   V  F   P  Y+LC +P HHH
Sbjct  416  ICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIPIHHH  475

Query  479  H  479
            H
Sbjct  476  H  476

Hit Number: 16, Accession Number: 5X23_A
pdb|5X23|A Chain A, Cytochrome P450 2C9 [Homo sapiens]
Length = 476, Score = 367 bits (943), Expect = 2e-122,
Identities = 203/481 (42%), Positives = 288/481 (60%), Gaps = 7/481 (1%)
Query  1    MAKKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLN  60
            MAKKTS +GKLPPGP PLP +GN+L +  ++       L + +G VF+L     P+VVL+
Sbjct  1    MAKKTSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLH  60

Query  61   GLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNL  120
            G  AV+EAL+  GE+ + R   P+ +      R  G+  +  G  W+E RRFS+ TLRN 
Sbjct  61   GYEAVKEALIDLGEEFSGRGIFPLAERAN---RGFGIVFSN-GKKWKEIRRFSLMTLRNF  116

Query  121  GLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRF  180
            G+GK+S+E  V EEA CL          P  P  +L  A  NVI S+   +RF+Y D +F
Sbjct  117  GMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQF  176

Query  181  LRLLDLAQEGLKE-ESGFLREVLNAVPVDRHIPALAGKVLRFQKAFLTQLDELLTEHRMT  239
            L L++   E +K   S +++   N  P+  + P    K+L+      + + E + EH+ +
Sbjct  177  LNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQES  236

Query  240  WDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLM  299
             D    P+D  + FL +MEK K N  S F  E+L     DLF AG  TTSTTL + LLL+
Sbjct  237  MD-MNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLL  295

Query  300  ILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRD  359
            + HP+V  +VQ+EI+ VIG+ R P M D++HMPYT AV+HEVQR+ D++P  + H  + D
Sbjct  296  LKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCD  355

Query  360  IEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRR  419
            I+ + + IPKGTT++ +L+SVL D   +  P  F P HFLD  G+F K + F+PFSAG+R
Sbjct  356  IKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKR  415

Query  420  ACLGEPLARMELFLFFTSLLQHFSF-SVPTGQPRPSHHGVFAFLVSPSPYELCAVPRHHH  478
             C+GE LA MELFLF TS+LQ+F+  S+   +   +   V  F   P  Y+LC +P HHH
Sbjct  416  ICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFTSVPPFYQLCFIPIHHH  475

Query  479  H  479
            H
Sbjct  476  H  476

Hit Number: 17, Accession Number: 7RL2_A
pdb|7RL2|A Chain A, Cytochrome P450 2C9 [Homo sapiens]
Length = 476, Score = 367 bits (942), Expect = 2e-122,
Identities = 203/481 (42%), Positives = 288/481 (60%), Gaps = 7/481 (1%)
Query  1    MAKKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLN  60
            MAKKTS +GKLPPGP PLP +GN+L +  ++       L + +G VF+L     P+VVL+
Sbjct  1    MAKKTSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLH  60

Query  61   GLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNL  120
            G  AV+EAL+  GE+ + R   P+ +      R  G+  +  G  W+E RRFS+ TLRN 
Sbjct  61   GYEAVKEALIDLGEEFSGRGIFPLAERAN---RGFGIVFSN-GKKWKEIRRFSLMTLRNF  116

Query  121  GLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRF  180
            G+GK+S+E  V EEA CL          P  P  +L  A  NVI S+   +RF+Y D +F
Sbjct  117  GMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQF  176

Query  181  LRLLDLAQEGLKE-ESGFLREVLNAVPVDRHIPALAGKVLRFQKAFLTQLDELLTEHRMT  239
            L L++   E +K   S +++   N  P+  + P    K+L+      + + E + EH+ +
Sbjct  177  LNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQES  236

Query  240  WDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLM  299
             D    P+D  + FL +MEK K N  S F  E+L     DLF AG  TTSTTL + LLL+
Sbjct  237  MD-MNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLL  295

Query  300  ILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRD  359
            + HP+V  +VQ+EI+ VIG+ R P M D++HMPYT AV+HEVQR+ D++P  + H  + D
Sbjct  296  LKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCD  355

Query  360  IEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRR  419
            I+ + + IPKGTT++ +L+SVL D   +  P  F P HFLD  G+F K + F+PFSAG+R
Sbjct  356  IKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKR  415

Query  420  ACLGEPLARMELFLFFTSLLQHFSF-SVPTGQPRPSHHGVFAFLVSPSPYELCAVPRHHH  478
             C+GE LA MELFLF TS+LQ+F+  S+   +   +   V  F   P  Y+LC +P HHH
Sbjct  416  ICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIPIHHH  475

Query  479  H  479
            H
Sbjct  476  H  476

Hit Number: 18, Accession Number: 4GQS_A
pdb|4GQS|A Chain A, Cytochrome P450 2C19 [Homo sapiens]
Length = 477, Score = 366 bits (940), Expect = 4e-122,
Identities = 204/482 (42%), Positives = 288/482 (60%), Gaps = 8/482 (2%)
Query  1    MAKKTSS-KGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVL  59
            MAKKTSS +GKLPPGP PLP +GN+L +D ++       L + +G VF+L      +VVL
Sbjct  1    MAKKTSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVL  60

Query  60   NGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRN  119
            +G   V+EAL+  GE+ + R   P+ +      R  G+  +  G  W+E RRFS+ TLRN
Sbjct  61   HGYEVVKEALIDLGEEFSGRGHFPLAERAN---RGFGIVFSN-GKRWKEIRRFSLMTLRN  116

Query  120  LGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPR  179
             G+GK+S+E  V EEA CL          P  P  +L  A  NVI S+   +RF+Y D +
Sbjct  117  FGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQ  176

Query  180  FLRLLDLAQEGLKEESGFLREVLNAVP-VDRHIPALAGKVLRFQKAFLTQLDELLTEHRM  238
            FL L++   E ++  S    ++ N  P +  + P    K+L+      + + E + EH+ 
Sbjct  177  FLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQE  236

Query  239  TWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLL  298
            + D    PRD  + FL +MEK K N +S F  ENL I  ADL  AG  TTSTTL + LLL
Sbjct  237  SMD-INNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLL  295

Query  299  MILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSR  358
            ++ HP+V  +VQ+EI+ V+G+ R P M D+ HMPYT AV+HEVQR+ D++P  + H  + 
Sbjct  296  LLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTC  355

Query  359  DIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGR  418
            D++ + + IPKGTT++T+L+SVL D   +  P  F P HFLD  G+F K   F+PFSAG+
Sbjct  356  DVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGK  415

Query  419  RACLGEPLARMELFLFFTSLLQHFSF-SVPTGQPRPSHHGVFAFLVSPSPYELCAVPRHH  477
            R C+GE LARMELFLF T +LQ+F+  S+   +   +   V  F   P  Y+LC +P HH
Sbjct  416  RICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIPIHH  475

Query  478  HH  479
            HH
Sbjct  476  HH  477

Hit Number: 19, Accession Number: 1DT6_A
pdb|1DT6|A Chain A, CYTOCHROME P450 2C5 [Oryctolagus cuniculus]
Length = 473, Score = 366 bits (939), Expect = 5e-122,
Identities = 210/482 (44%), Positives = 290/482 (60%), Gaps = 12/482 (2%)
Query  1    MAKKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLN  60
            MAKKTSSKGKLPPGP P P +GN+L +D ++      +    +G VF++ L   P VVL+
Sbjct  1    MAKKTSSKGKLPPGPTPFPIIGNILQIDAKDISKSLTKFSECYGPVFTVYLGMKPTVVLH  60

Query  61   GLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLA-RYGPAWREQRRFSVSTLRN  119
            G  AV+EALV  GE+ A R  VPI + +     S+G+ +A      W+E RRFS+ TLRN
Sbjct  61   GYEAVKEALVDLGEEFAGRGSVPILEKV-----SKGLGIAFSNAKTWKEMRRFSLMTLRN  115

Query  120  LGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPR  179
             G+GK+S+E  + EEA CL       +  P  P  +L  A  NVI S+    RF+Y D  
Sbjct  116  FGMGKRSIEDRIQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHNRFDYKDEE  175

Query  180  FLRLLDLAQEGLKEESGFLREVLNAVP-VDRHIPALAGKVLRFQKAFLTQLDELLTEHRM  238
            FL+L++   E ++       +V N  P +  + P +   +L+        + E + EH+ 
Sbjct  176  FLKLMESLHENVELLGTPWLQVYNNFPALLDYFPGIHKTLLKNADYIKNFIMEKVKEHQK  235

Query  239  TWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLL  298
              D    PRD  + FL +ME+ + N E  F  E+L I V+DLF AG  TTSTTL + LLL
Sbjct  236  LLD-VNNPRDFIDCFLIKMEQ-ENNLE--FTLESLVIAVSDLFGAGTETTSTTLRYSLLL  291

Query  299  MILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSR  358
            ++ HP+V  RVQ+EI+ VIG+ R P M D++ MPYT AVIHE+QRF D++P  + H  +R
Sbjct  292  LLKHPEVAARVQEEIERVIGRHRSPCMQDRSRMPYTDAVIHEIQRFIDLLPTNLPHAVTR  351

Query  359  DIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGR  418
            D+  + + IPKGT +IT+L+SVL DE  +  P  F P HFLD  G+F K + F+PFSAG+
Sbjct  352  DVRFRNYFIPKGTDIITSLTSVLHDEKAFPNPKVFDPGHFLDESGNFKKSDYFMPFSAGK  411

Query  419  RACLGEPLARMELFLFFTSLLQHFSF-SVPTGQPRPSHHGVFAFLVSPSPYELCAVPRHH  477
            R C+GE LARMELFLF TS+LQ+F   S+   +       V  F+  P  Y+LC +P HH
Sbjct  412  RMCVGEGLARMELFLFLTSILQNFKLQSLVEPKDLDITAVVNGFVSVPPSYQLCFIPIHH  471

Query  478  HH  479
            HH
Sbjct  472  HH  473

Hit Number: 20, Accession Number: 3E4E_A
pdb|3E4E|A Chain A, Cytochrome P450 2E1 [Homo sapiens]
Length = 476, Score = 366 bits (939), Expect = 7e-122,
Identities = 202/485 (42%), Positives = 284/485 (59%), Gaps = 16/485 (3%)
Query  1    MAKKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLN  60
            MAKKTSSKGKLPPGP PLP +GNL  ++ +N P  F +L +RFG VF+L +    +VV++
Sbjct  1    MAKKTSSKGKLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMH  60

Query  61   GLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNL  120
            G  AV+EAL+ + ++ + R  +P         R +G+     GP W++ RRFS++TLRN 
Sbjct  61   GYKAVKEALLDYKDEFSGRGDLPAFH----AHRDRGIIFNN-GPTWKDIRRFSLTTLRNY  115

Query  121  GLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRF  180
            G+GK+  E  +  EA  L  A     G+PF P  L+  A  NVIA +   + F+Y+D +F
Sbjct  116  GMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKF  175

Query  181  LRLLDLAQEGLKEESGFLREVLNAVPVDRH-IPALAGKVLRFQKAFLTQLDELLTEHRMT  239
            LRL+ L  E     S    ++ N  P   H +P    KV++        + E + EH  +
Sbjct  176  LRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQS  235

Query  240  WDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLM  299
             DP   PRDLT+  L EMEK K + E  +  + + + VADLF AG  TTSTTL +GLL++
Sbjct  236  LDP-NCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLIL  294

Query  300  ILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRD  359
            + +P+++ ++ +EID VIG  R P + D+  MPY  AV+HE+QRF  +VP  + H  +RD
Sbjct  295  MKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRD  354

Query  360  IEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRR  419
               +G+ IPKGT ++  L SVL D   +  P +F PEHFL+  G F   + F PFS G+R
Sbjct  355  TIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKR  414

Query  420  ACLGEPLARMELFLFFTSLLQHFSFSVPTGQPR-----PSHHGVFAFLVSPSPYELCAVP  474
             C GE LARMELFL   ++LQHF+   P   P+     P H G   F   P  Y+LC +P
Sbjct  415  VCAGEGLARMELFLLLCAILQHFNLK-PLVDPKDIDLSPIHIG---FGCIPPRYKLCVIP  470

Query  475  RHHHH  479
            R HHH
Sbjct  471  RSHHH  475

Hit Number: 21, Accession Number: 1R9O_A
pdb|1R9O|A Chain A, Cytochrome P450 2C9 [Homo sapiens]
Length = 477, Score = 364 bits (935), Expect = 2e-121,
Identities = 204/482 (42%), Positives = 289/482 (60%), Gaps = 8/482 (2%)
Query  1    MAKKTSS-KGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVL  59
            MAKKTSS +GKLPPGP PLP +GN+L +  ++       L + +G VF+L     P+VVL
Sbjct  1    MAKKTSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVL  60

Query  60   NGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRN  119
            +G  AV+EAL+  GE+ + R   P+ +      R  G+  +  G  W+E RRFS+ TLRN
Sbjct  61   HGYEAVKEALIDLGEEFSGRGIFPLAERAN---RGFGIVFSN-GKKWKEIRRFSLMTLRN  116

Query  120  LGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPR  179
             G+GK+S+E  V EEA CL          P  P  +L  A  NVI S+   +RF+Y D +
Sbjct  117  FGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQ  176

Query  180  FLRLLDLAQEGLKE-ESGFLREVLNAVPVDRHIPALAGKVLRFQKAFLTQLDELLTEHRM  238
            FL L++   E +K   S +++   N  P+  + P    K+L+      + + E + EH+ 
Sbjct  177  FLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQE  236

Query  239  TWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLL  298
            + D    P+D  + FL +MEK K N  S F  E+L     DLF AG  TTSTTL + LLL
Sbjct  237  SMD-MNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLL  295

Query  299  MILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSR  358
            ++ HP+V  +VQ+EI+ VIG+ R P M D++HMPYT AV+HEVQR+ D++P  + H  + 
Sbjct  296  LLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTC  355

Query  359  DIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGR  418
            DI+ + + IPKGTT++ +L+SVL D   +  P  F P HFLD  G+F K + F+PFSAG+
Sbjct  356  DIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGK  415

Query  419  RACLGEPLARMELFLFFTSLLQHFSF-SVPTGQPRPSHHGVFAFLVSPSPYELCAVPRHH  477
            R C+GE LA MELFLF TS+LQ+F+  S+   +   +   V  F   P  Y+LC +P HH
Sbjct  416  RICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIPIHH  475

Query  478  HH  479
            HH
Sbjct  476  HH  477

Hit Number: 22, Accession Number: 2P85_A
pdb|2P85|A Chain A, Cytochrome P450 2A13 [Homo sapiens]
Length = 476, Score = 360 bits (923), Expect = 1e-119,
Identities = 199/486 (41%), Positives = 287/486 (59%), Gaps = 17/486 (3%)
Query  1    MAKKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLN  60
            MAKKTSSKGKLPPGP PLP +GN L ++ +       ++  R+G VF++ L    VVVL 
Sbjct  1    MAKKTSSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLC  60

Query  61   GLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNL  120
            G  AV+EALV   E+ + R        L  G    GV  +  G   ++ RRFS++TLR  
Sbjct  61   GHDAVKEALVDQAEEFSGRGEQATFDWLFKG---YGVAFSN-GERAKQLRRFSIATLRGF  116

Query  121  GLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRF  180
            G+GK+ +E+ + EEA  L  A     G    P   L + VSNVI+S+  G RF+Y+D  F
Sbjct  117  GVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEF  176

Query  181  LRLLDLAQEGLK---EESGFLREVLNAVPVDRHIPALAGKVLRFQKAFLTQLDELLTEHR  237
            L LL +     +     +G L E+ ++V   +H+P    +  +  +     + + +  ++
Sbjct  177  LSLLRMMLGSFQFTATSTGQLYEMFSSVM--KHLPGPQQQAFKELQGLEDFIAKKVEHNQ  234

Query  238  MTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLL  297
             T DP   PRD  ++FL  M++ + NP + F  +NL +   +LF AG  T STTL +G L
Sbjct  235  RTLDP-NSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGFL  293

Query  298  LMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTS  357
            L++ HP+V+ +V +EID VIG+ R+P+  D+A MPYT AVIHE+QRFGD++P+G+ H  +
Sbjct  294  LLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRVN  353

Query  358  RDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAG  417
            +D + + F +PKGT +   L SVL+D   +  P  F+P+HFLD +G F K +AF+PFS G
Sbjct  354  KDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKKSDAFVPFSIG  413

Query  418  RRACLGEPLARMELFLFFTSLLQHFSFSVPTG----QPRPSHHGVFAFLVSPSPYELCAV  473
            +R C GE LARMELFLFFT+++Q+F F  P         P H G   F   P  Y +  +
Sbjct  414  KRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVG---FATIPRNYTMSFL  470

Query  474  PRHHHH  479
            PRHHHH
Sbjct  471  PRHHHH  476

Hit Number: 23, Accession Number: 1OG2_A
pdb|1OG2|A Chain A, CYTOCHROME P450 2C9 [Homo sapiens]
Length = 475, Score = 360 bits (923), Expect = 2e-119,
Identities = 203/481 (42%), Positives = 287/481 (60%), Gaps = 8/481 (2%)
Query  1    MAKKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLN  60
            MAKKTSSKG+ PPGP PLP +GN+L +  ++       L + +G VF+L     P+VVL+
Sbjct  1    MAKKTSSKGR-PPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLH  59

Query  61   GLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNL  120
            G  AV+EAL+  GE+ + R   P+ +      R  G+  +  G  W+E RRFS+ TLRN 
Sbjct  60   GYEAVKEALIDLGEEFSGRGIFPLAERAN---RGFGIVFSN-GKKWKEIRRFSLMTLRNF  115

Query  121  GLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRF  180
            G+GK+S+E  V EEA CL          P  P  +L  A  NVI S+   +RF+Y D +F
Sbjct  116  GMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQF  175

Query  181  LRLLDLAQEGLKEESGFLREVLNAVP-VDRHIPALAGKVLRFQKAFLTQLDELLTEHRMT  239
            L L++   E ++  S    +V N  P +  + P    K+L+      + + E + EH+ +
Sbjct  176  LNLMEKLNENIEILSSPWIQVYNNFPALLDYFPGTHNKLLKNVAFMKSYILEKVKEHQES  235

Query  240  WDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLM  299
             D    P+D  + FL +MEK K N  S F  E+L     DLF AG  TTSTTL + LLL+
Sbjct  236  MD-MNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLL  294

Query  300  ILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRD  359
            + HP+V  +VQ+EI+ VIG+ R P M D++HMPYT AV+HEVQR+ D++P  + H  + D
Sbjct  295  LKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCD  354

Query  360  IEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRR  419
            I+ + + IPKGTT++ +L+SVL D   +  P  F P HFLD  G+F K + F+PFSAG+R
Sbjct  355  IKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKR  414

Query  420  ACLGEPLARMELFLFFTSLLQHFSF-SVPTGQPRPSHHGVFAFLVSPSPYELCAVPRHHH  478
             C+GE LA MELFLF TS+LQ+F+  S+   +   +   V  F   P  Y+LC +P HHH
Sbjct  415  ICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIPVHHH  474

Query  479  H  479
            H
Sbjct  475  H  475

Hit Number: 24, Accession Number: 5EM4_A
pdb|5EM4|A Chain A, Cytochrome P450 2B4 [Oryctolagus cuniculus]
Length = 492, Score = 358 bits (919), Expect = 9e-119,
Identities = 195/444 (44%), Positives = 266/444 (60%), Gaps = 6/444 (1%)
Query  6    SSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAV  65
             + GKLPPGP PLP LGNLL +D +     F +LR ++GDVF++ L   PVVVL G  A+
Sbjct  25   KAHGKLPPGPSPLPVLGNLLQMDRKGLLRSFLRLREKYGDVFTVYLGSRPVVVLCGTDAI  84

Query  66   REALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKK  125
            REALV   E  + R  + +   +  G    GV  A  G  WR  RRFS++T+R+ G+GK+
Sbjct  85   REALVDQAEAFSGRGKIAVVDPIFQG---YGVIFAN-GERWRALRRFSLATMRDFGMGKR  140

Query  126  SLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLD  185
            S+E+ + EEA CL        G       L     SN+I S+  G+RF+Y DP FLRLLD
Sbjct  141  SVEERIQEEARCLVEELRKSKGALLDNTLLFHSITSNIICSIVFGKRFDYKDPVFLRLLD  200

Query  186  LAQEGLKEESGFLREVLNAVP-VDRHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQ  244
            L  +     S F  +V        ++ P    ++ R  +   T + + + +HR T DP+ 
Sbjct  201  LFFQSFSLISSFSSQVFELFSGFLKYFPGTHRQIYRNLQEINTWIGQSVEKHRATLDPSN  260

Query  245  PPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPD  304
            P RD  + +L  MEK K +P S F+ +NL + V  LF AG  TTSTTL +G LLM+ +P 
Sbjct  261  P-RDFIDVYLLRMEKDKSDPSSEFHHQNLILTVLSLFFAGTETTSTTLRYGFLLMLKYPH  319

Query  305  VQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRDIEVQG  364
            V  RVQ+EI+ VIG  R P + D+A MPYT AVIHE+QR GD++P G+ H  ++D + +G
Sbjct  320  VTERVQKEIEQVIGSHRPPALDDRAKMPYTDAVIHEIQRLGDLIPFGVPHTVTKDTQFRG  379

Query  365  FRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGE  424
            + IPK T +   LSS L D   +E P  F+P HFLDA G   + E F+PFS G+R CLGE
Sbjct  380  YVIPKNTEVFPVLSSALHDPRYFETPNTFNPGHFLDANGALKRNEGFMPFSLGKRICLGE  439

Query  425  PLARMELFLFFTSLLQHFSFSVPT  448
             +AR ELFLFFT++LQ+FS + P 
Sbjct  440  GIARTELFLFFTTILQNFSIASPV  463

Hit Number: 25, Accession Number: 8VX0_A
pdb|8VX0|A Chain A, Cytochrome P450 2C9 [Homo sapiens]
Length = 473, Score = 357 bits (915), Expect = 2e-118,
Identities = 199/478 (42%), Positives = 284/478 (59%), Gaps = 7/478 (1%)
Query  1    MAKKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLN  60
            MAKKTS +GKLPPGP PLP +GN+L +  ++       L + +G VF+L     P+VVL+
Sbjct  1    MAKKTSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLH  60

Query  61   GLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNL  120
            G  AV+EAL+  GE+ + R   P+ +      R  G+  +  G  W+E R FS+ TLRN 
Sbjct  61   GYEAVKEALIDLGEEFSGRGIFPLAERAN---RGFGIVFSN-GKKWKEIRHFSLMTLRNF  116

Query  121  GLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRF  180
            G+GK+S+E  V EEA CL          P  P  +L  A  NVI S+   +RF+Y D +F
Sbjct  117  GMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQF  176

Query  181  LRLLDLAQEGLKE-ESGFLREVLNAVPVDRHIPALAGKVLRFQKAFLTQLDELLTEHRMT  239
            L L++   E +K   S +++   N  P+  + P    K+L+      + + E + EH+ +
Sbjct  177  LNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQES  236

Query  240  WDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLM  299
             D    P+D  + FL +MEK K N  S F  E+L     DLF AG  TTSTTL + LLL+
Sbjct  237  MD-MNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLL  295

Query  300  ILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRD  359
            + HP+V  +VQ+EI+ VIG+ R P M D++HMPYT AV+HEVQR+ D++P  + H  + D
Sbjct  296  LKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCD  355

Query  360  IEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRR  419
            I+ + + IPKGTT++ +L+SVL D   +  P  F P HFLD  G+F K + F+PFSAG+R
Sbjct  356  IKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKR  415

Query  420  ACLGEPLARMELFLFFTSLLQHFSF-SVPTGQPRPSHHGVFAFLVSPSPYELCAVPRH  476
             C+GE LA MELFLF TS+LQ+F+  S+   +   +   V  F   P  Y+LC +P H
Sbjct  416  ICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIPIH  473

Hit Number: 26, Accession Number: 3EBS_A
pdb|3EBS|A Chain A, Cytochrome P450 2A6 [Homo sapiens]
Length = 476, Score = 352 bits (903), Expect = 1e-116,
Identities = 194/487 (40%), Positives = 286/487 (59%), Gaps = 19/487 (4%)
Query  1    MAKKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLN  60
            MAKKTSSKGKLPPGP PLP +GN L ++ +       ++  R+G VF++ L    VVVL 
Sbjct  1    MAKKTSSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLC  60

Query  61   GLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNL  120
            G  AVREALV   E+ + R          +  +  GV  +  G   ++ RRFS++TLR+ 
Sbjct  61   GHDAVREALVDQAEEFSGRGE---QATFDWVFKGYGVVFSN-GERAKQLRRFSIATLRDF  116

Query  121  GLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRF  180
            G+GK+ +E+ + EEA  L  A     G    P   L + VSNVI+S+  G RF+Y D  F
Sbjct  117  GVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEF  176

Query  181  LRLLDLAQEGLK---EESGFLREVLNAVPVDRHIPALAGKVLRFQKAFLTQLDELLTEHR  237
            L LL +     +     +G L E+ ++V   +H+P    +  +  +     + + +  ++
Sbjct  177  LSLLRMMLGSFQFTSTSTGQLYEMFSSVM--KHLPGPQQQAFQLLQGLEDFIAKKVEHNQ  234

Query  238  MTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLL  297
             T DP   PRD  ++FL  M++ + NP + F  +NL +   +LF AG  T STTL +G L
Sbjct  235  RTLDP-NSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGFL  293

Query  298  LMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTS  357
            L++ HP+V+ +V +EID VIG+ R+P+  D+A MPY  AVIHE+QRFGD++P+G+     
Sbjct  294  LLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMGLARRVK  353

Query  358  RDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAG  417
            +D + + F +PKGT +   L SVL+D + +  P  F+P+HFL+ +G F K +AF+PFS G
Sbjct  354  KDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIG  413

Query  418  RRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPR-----PSHHGVFAFLVSPSPYELCA  472
            +R C GE LARMELFLFFT+++Q+F     +  P+     P H G   F   P  Y +  
Sbjct  414  KRNCFGEGLARMELFLFFTTVMQNFRLK-SSQSPKDIDVSPKHVG---FATIPRNYTMSF  469

Query  473  VPRHHHH  479
            +PRHHHH
Sbjct  470  LPRHHHH  476

Hit Number: 27, Accession Number: 1Z10_A
pdb|1Z10|A Chain A, cytochrome P450, family 2, subfamily A, polypeptide 6 [Homo sapiens]
Length = 476, Score = 348 bits (892), Expect = 7e-115,
Identities = 192/487 (39%), Positives = 284/487 (58%), Gaps = 19/487 (4%)
Query  1    MAKKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLN  60
            MAKKTSSKGKLPPGP PLP +GN L ++ +       ++  R+G VF++ L    VVVL 
Sbjct  1    MAKKTSSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLC  60

Query  61   GLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNL  120
            G  AVREALV   E+ + R          +  +  GV  +  G   ++ RRFS++TLR+ 
Sbjct  61   GHDAVREALVDQAEEFSGRGE---QATFDWVFKGYGVVFSN-GERAKQLRRFSIATLRDF  116

Query  121  GLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRF  180
            G+GK+ +E+ + EEA  L  A     G    P   L + VSNVI+S+  G RF+Y D  F
Sbjct  117  GVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEF  176

Query  181  LRLLDLAQ---EGLKEESGFLREVLNAVPVDRHIPALAGKVLRFQKAFLTQLDELLTEHR  237
            L LL +     +     +G L E+ ++V   +H+P    +  +  +     + + +  ++
Sbjct  177  LSLLRMMLGIFQFTSTSTGQLYEMFSSVM--KHLPGPQQQAFQLLQGLEDFIAKKVEHNQ  234

Query  238  MTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLL  297
             T DP   PRD  ++FL  M++ + NP + F  +NL +   +LF  G  T STTL +G L
Sbjct  235  RTLDP-NSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFL  293

Query  298  LMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTS  357
            L++ HP+V+ +V +EID VIG+ R+P+  D+A MPY  AVIHE+QRFGD++P+ +     
Sbjct  294  LLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVK  353

Query  358  RDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAG  417
            +D + + F +PKGT +   L SVL+D + +  P  F+P+HFL+ +G F K +AF+PFS G
Sbjct  354  KDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIG  413

Query  418  RRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPR-----PSHHGVFAFLVSPSPYELCA  472
            +R C GE LARMELFLFFT+++Q+F     +  P+     P H G   F   P  Y +  
Sbjct  414  KRNCFGEGLARMELFLFFTTVMQNFRLK-SSQSPKDIDVSPKHVG---FATIPRNYTMSF  469

Query  473  VPRHHHH  479
            +PRHHHH
Sbjct  470  LPRHHHH  476

Hit Number: 28, Accession Number: 3IBD_A
pdb|3IBD|A Chain A, Cytochrome P450 2B6 [Homo sapiens]
Length = 476, Score = 347 bits (891), Expect = 8e-115,
Identities = 206/484 (43%), Positives = 284/484 (59%), Gaps = 13/484 (3%)
Query  1    MAKKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLN  60
            MAKKTSSKGKLPPGP PLP LGNLL +D +     F + R ++GDVF++ L   PVV+L 
Sbjct  1    MAKKTSSKGKLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLC  60

Query  61   GLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNL  120
            G+ A+REALV   E  + R  + +        R  GV  A  G  W+  RRFSV+T+R+ 
Sbjct  61   GVEAIREALVDKAEAFSGRGKIAMVDPFF---RGYGVIFAN-GNRWKVLRRFSVTTMRDF  116

Query  121  GLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRF  180
            G+GK+S+E+ + EEA CL        G    P  L     +N+I S+  G+RF Y D  F
Sbjct  117  GMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEF  176

Query  181  LRLLDLAQEGLKEESGFLREVLNAVP-VDRHIPALAGKVLRFQKAFLTQLDELLTEHRMT  239
            L++L+L  +     S    ++        +H P    +V +  +     +   + +HR T
Sbjct  177  LKMLNLFYQTFSLISSVFGQLFELFSGFLKHFPGAHRQVYKNLQEINAYIGHSVEKHRET  236

Query  240  WDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLM  299
             DP+  PRDL + +L  MEK K N  S F+ +NL +    LF AG  TTSTTL +G LLM
Sbjct  237  LDPS-APRDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLM  295

Query  300  ILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRD  359
            + +P V  RV +EI+ VIG  R PE+ D+A MPYT AVI+E+QRF D++P+G+ H+ ++ 
Sbjct  296  LKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQH  355

Query  360  IEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRR  419
               +G+ IPK T +   LS+ L D   +EKP  F+P+HFLDA G   K EAF+PFS G+R
Sbjct  356  TSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKR  415

Query  420  ACLGEPLARMELFLFFTSLLQHFSFSVPTG----QPRPSHHGVFAFLVSPSPYELCAVPR  475
             CLGE +AR ELFLFFT++LQ+FS + P         P   GV      P  Y++  +PR
Sbjct  416  ICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKI---PPTYQIRFLPR  472

Query  476  HHHH  479
            HHHH
Sbjct  473  HHHH  476

Hit Number: 29, Accession Number: 5UFG_A
pdb|5UFG|A Chain A, Cytochrome P450 2B6 [Homo sapiens]
Length = 476, Score = 347 bits (891), Expect = 1e-114,
Identities = 206/484 (43%), Positives = 284/484 (59%), Gaps = 13/484 (3%)
Query  1    MAKKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLN  60
            MAKKTSSKGKLPPGP PLP LGNLL +D +     F + R ++GDVF++ L   PVV+L 
Sbjct  1    MAKKTSSKGKLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLC  60

Query  61   GLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNL  120
            G+ A+REALV   E  + R  + +        R  GV  A  G  W+  RRFSV+T+R+ 
Sbjct  61   GVEAIREALVDKAEAFSGRGKIAMVDPFF---RGYGVVFAN-GNRWKVLRRFSVTTMRDF  116

Query  121  GLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRF  180
            G+GK+S+E+ + EEA CL        G    P  L     +N+I S+  G+RF Y D  F
Sbjct  117  GMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEF  176

Query  181  LRLLDLAQEGLKEESGFLREVLNAVP-VDRHIPALAGKVLRFQKAFLTQLDELLTEHRMT  239
            L++L+L  +     S    ++        +H P    +V +  +     +   + +HR T
Sbjct  177  LKMLNLFYQTFSLISSVFGQLFELFSGFLKHFPGAHRQVYKNLQEINAYIGHSVEKHRET  236

Query  240  WDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLM  299
             DP+  PRDL + +L  MEK K N  S F+ +NL +    LF AG  TTSTTL +G LLM
Sbjct  237  LDPS-APRDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLM  295

Query  300  ILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRD  359
            + +P V  RV +EI+ VIG  R PE+ D+A MPYT AVI+E+QRF D++P+G+ H+ ++ 
Sbjct  296  LKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQH  355

Query  360  IEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRR  419
               +G+ IPK T +   LS+ L D   +EKP  F+P+HFLDA G   K EAF+PFS G+R
Sbjct  356  TSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKR  415

Query  420  ACLGEPLARMELFLFFTSLLQHFSFSVPTG----QPRPSHHGVFAFLVSPSPYELCAVPR  475
             CLGE +AR ELFLFFT++LQ+FS + P         P   GV      P  Y++  +PR
Sbjct  416  ICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKI---PPTYQIRFLPR  472

Query  476  HHHH  479
            HHHH
Sbjct  473  HHHH  476

Hit Number: 30, Accession Number: 2PG7_A
pdb|2PG7|A Chain A, Cytochrome P450 2A6 [Homo sapiens]
Length = 476, Score = 347 bits (890), Expect = 1e-114,
Identities = 192/487 (39%), Positives = 283/487 (58%), Gaps = 19/487 (4%)
Query  1    MAKKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLN  60
            MAKKTSSKGKLPPGP PLP +GN L ++ +       ++  R+G VF++ L    VVVL 
Sbjct  1    MAKKTSSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLC  60

Query  61   GLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNL  120
            G  AVREALV   E+ + R          +  +  GV  +  G   ++ RRFS++TLR+ 
Sbjct  61   GHDAVREALVDQAEEFSGRGE---QATFDWVFKGYGVVFSN-GERAKQLRRFSIATLRDF  116

Query  121  GLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRF  180
            G+GK+ +E+ + EEA  L  A     G    P   L + VSNVI+S+  G RF+Y D  F
Sbjct  117  GVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEF  176

Query  181  LRLLDLAQ---EGLKEESGFLREVLNAVPVDRHIPALAGKVLRFQKAFLTQLDELLTEHR  237
            L LL +     +     +G L E+ ++V   +H+P    +  +  +     + + +  ++
Sbjct  177  LSLLRMMLGIFQFTSTSTGQLYEMFSSVM--KHLPGPQQQAFQLLQGLEDFIAKKVEHNQ  234

Query  238  MTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLL  297
             T DP   PRD  ++FL  M++ + NP + F  +NL +    LF  G  T STTL +G L
Sbjct  235  RTLDP-NSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLQLFVGGTETVSTTLRYGFL  293

Query  298  LMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTS  357
            L++ HP+V+ +V +EID VIG+ R+P+  D+A MPY  AVIHE+QRFGD++P+ +     
Sbjct  294  LLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVK  353

Query  358  RDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAG  417
            +D + + F +PKGT +   L SVL+D + +  P  F+P+HFL+ +G F K +AF+PFS G
Sbjct  354  KDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIG  413

Query  418  RRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPR-----PSHHGVFAFLVSPSPYELCA  472
            +R C GE LARMELFLFFT+++Q+F     +  P+     P H G   F   P  Y +  
Sbjct  414  KRNCFGEGLARMELFLFFTTVMQNFRLK-SSQSPKDIDVSPKHVG---FATIPRNYTMSF  469

Query  473  VPRHHHH  479
            +PRHHHH
Sbjct  470  LPRHHHH  476

Hit Number: 31, Accession Number: 4ZV8_A
pdb|4ZV8|A Chain A, Cytochrome P450 2B6 [Homo sapiens]
Length = 476, Score = 347 bits (890), Expect = 1e-114,
Identities = 206/484 (43%), Positives = 284/484 (59%), Gaps = 13/484 (3%)
Query  1    MAKKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLN  60
            MAKKTSSKGKLPPGP PLP LGNLL +D +     F + R ++GDVF++ L   PVV+L 
Sbjct  1    MAKKTSSKGKLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLC  60

Query  61   GLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNL  120
            G+ A+REALV   E  + R  + +        R  GV  A  G  W+  RRFSV+T+R+ 
Sbjct  61   GVEAIREALVDKAEAFSGRGKIAMVDPFF---RGYGVIFAN-GNRWKVLRRFSVTTMRDF  116

Query  121  GLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRF  180
            G+GK+S+E+ + EEA CL        G    P  L     +N+I S+  G+RF Y D  F
Sbjct  117  GMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEF  176

Query  181  LRLLDLAQEGLKEESGFLREVLNAVP-VDRHIPALAGKVLRFQKAFLTQLDELLTEHRMT  239
            L++L+L  +     S    ++        +H P    +V +  +     +   + +HR T
Sbjct  177  LKMLNLFYQTFSLISSVFGQLFELFSGFLKHFPGAHRQVYKNLQEINAWIGHSVEKHRET  236

Query  240  WDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLM  299
             DP+  PRDL + +L  MEK K N  S F+ +NL +    LF AG  TTSTTL +G LLM
Sbjct  237  LDPS-APRDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLM  295

Query  300  ILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRD  359
            + +P V  RV +EI+ VIG  R PE+ D+A MPYT AVI+E+QRF D++P+G+ H+ ++ 
Sbjct  296  LKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQH  355

Query  360  IEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRR  419
               +G+ IPK T +   LS+ L D   +EKP  F+P+HFLDA G   K EAF+PFS G+R
Sbjct  356  TSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKR  415

Query  420  ACLGEPLARMELFLFFTSLLQHFSFSVPTG----QPRPSHHGVFAFLVSPSPYELCAVPR  475
             CLGE +AR ELFLFFT++LQ+FS + P         P   GV      P  Y++  +PR
Sbjct  416  ICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKI---PPTYQIRFLPR  472

Query  476  HHHH  479
            HHHH
Sbjct  473  HHHH  476

Hit Number: 32, Accession Number: 2PG5_A
pdb|2PG5|A Chain A, Cytochrome P450 2A6 [Homo sapiens]
Length = 476, Score = 347 bits (889), Expect = 2e-114,
Identities = 192/487 (39%), Positives = 283/487 (58%), Gaps = 19/487 (4%)
Query  1    MAKKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLN  60
            MAKKTSSKGKLPPGP PLP +GN L ++ +       ++  R+G VF++ L    VVVL 
Sbjct  1    MAKKTSSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLC  60

Query  61   GLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNL  120
            G  AVREALV   E+ + R          +  +  GV  +  G   ++ RRFS++TLR+ 
Sbjct  61   GHDAVREALVDQAEEFSGRGE---QATFDWVFKGYGVVFSN-GERAKQLRRFSIATLRDF  116

Query  121  GLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRF  180
            G+GK+ +E+ + EEA  L  A     G    P   L + VSNVI+S+  G RF+Y D  F
Sbjct  117  GVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEF  176

Query  181  LRLLDLAQ---EGLKEESGFLREVLNAVPVDRHIPALAGKVLRFQKAFLTQLDELLTEHR  237
            L LL +     +     +G L E+ ++V   +H+P    +  +  +     + + +  ++
Sbjct  177  LSLLRMMLGIFQFTSTSTGQLYEMFSSVM--KHLPGPQQQAFQLLQGLEDFIAKKVEHNQ  234

Query  238  MTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLL  297
             T DP   PRD  ++FL  M++ + NP + F  +NL +    LF  G  T STTL +G L
Sbjct  235  RTLDP-NSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLQLFIGGTETVSTTLRYGFL  293

Query  298  LMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTS  357
            L++ HP+V+ +V +EID VIG+ R+P+  D+A MPY  AVIHE+QRFGD++P+ +     
Sbjct  294  LLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVK  353

Query  358  RDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAG  417
            +D + + F +PKGT +   L SVL+D + +  P  F+P+HFL+ +G F K +AF+PFS G
Sbjct  354  KDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIG  413

Query  418  RRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPR-----PSHHGVFAFLVSPSPYELCA  472
            +R C GE LARMELFLFFT+++Q+F     +  P+     P H G   F   P  Y +  
Sbjct  414  KRNCFGEGLARMELFLFFTTVMQNFRLK-SSQSPKDIDVSPKHVG---FATIPRNYTMSF  469

Query  473  VPRHHHH  479
            +PRHHHH
Sbjct  470  LPRHHHH  476

Hit Number: 33, Accession Number: 2PG6_A
pdb|2PG6|A Chain A, Cytochrome P450 2A6 [Homo sapiens]
Length = 476, Score = 345 bits (886), Expect = 5e-114,
Identities = 192/487 (39%), Positives = 283/487 (58%), Gaps = 19/487 (4%)
Query  1    MAKKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLN  60
            MAKKTSSKGKLPPGP PLP +GN L ++ +       ++  R+G VF++ L    VVVL 
Sbjct  1    MAKKTSSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLC  60

Query  61   GLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNL  120
            G  AVREALV   E+ + R          +  +  GV  +  G   ++ RRFS++TLR+ 
Sbjct  61   GHDAVREALVDQAEEFSGRGE---QATFDWVFKGYGVVFSN-GERAKQLRRFSIATLRDF  116

Query  121  GLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRF  180
            G+GK+ +E+ + EEA  L  A     G    P   L + VSNVI+S+  G RF+Y D  F
Sbjct  117  GVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEF  176

Query  181  LRLLDLAQ---EGLKEESGFLREVLNAVPVDRHIPALAGKVLRFQKAFLTQLDELLTEHR  237
            L LL +     +     +G L E+ ++V   +H+P    +  +  +     + + +  ++
Sbjct  177  LSLLRMMLGIFQFTSTSTGQLYEMFSSVM--KHLPGPQQQAFQCLQGLEDFIAKKVEHNQ  234

Query  238  MTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLL  297
             T DP   PRD  ++FL  M++ + NP + F  +NL +    LF  G  T STTL +G L
Sbjct  235  RTLDP-NSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLQLFIGGTETVSTTLRYGFL  293

Query  298  LMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTS  357
            L++ HP+V+ +V +EID VIG+ R+P+  D+A MPY  AVIHE+QRFGD++P+ +     
Sbjct  294  LLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVK  353

Query  358  RDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAG  417
            +D + + F +PKGT +   L SVL+D + +  P  F+P+HFL+ +G F K +AF+PFS G
Sbjct  354  KDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIG  413

Query  418  RRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPR-----PSHHGVFAFLVSPSPYELCA  472
            +R C GE LARMELFLFFT+++Q+F     +  P+     P H G   F   P  Y +  
Sbjct  414  KRNCFGEGLARMELFLFFTTVMQNFRLK-SSQSPKDIDVSPKHVG---FATIPRNYTMSF  469

Query  473  VPRHHHH  479
            +PRHHHH
Sbjct  470  LPRHHHH  476

Hit Number: 34, Accession Number: 5XXI_A
pdb|5XXI|A Chain A, Cytochrome P450 2C9 [Homo sapiens]
Length = 463, Score = 342 bits (878), Expect = 5e-113,
Identities = 192/467 (41%), Positives = 276/467 (59%), Gaps = 7/467 (1%)
Query  10   KLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREAL  69
            KLPPGP PLP +GN+L +  ++       L + +G VF+L     P+VVL+G  AV+EAL
Sbjct  1    KLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEAL  60

Query  70   VTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQ  129
            +  GE+ + R   P+ +      R  G+  +  G  W+E RRFS+ TLRN G+GK+S+E 
Sbjct  61   IDLGEEFSGRGIFPLAERAN---RGFGIVFSN-GKKWKEIRRFSLMTLRNFGMGKRSIED  116

Query  130  WVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQE  189
             V EEA CL          P  P  +L  A  NVI S+   +RF+Y D +FL L++   E
Sbjct  117  RVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNE  176

Query  190  GLKE-ESGFLREVLNAVPVDRHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRD  248
             +K   S +++   N  P+  + P    K+L+      + + E + EH+ + D    P+D
Sbjct  177  NIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMD-MNNPQD  235

Query  249  LTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRR  308
              + FL +MEK K N  S F  E+L     DLF AG  TTSTTL + LLL++ HP+V  +
Sbjct  236  FIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAK  295

Query  309  VQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRDIEVQGFRIP  368
            VQ+EI+ VIG+ R P M D++HMPYT AV+HEVQR+ D++P  + H  + DI+ + + IP
Sbjct  296  VQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIP  355

Query  369  KGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLAR  428
            KGTT++ +L+SVL D   +  P  F P HFLD  G+F K + F+PFSAG+R C+GE LA 
Sbjct  356  KGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAG  415

Query  429  MELFLFFTSLLQHFSF-SVPTGQPRPSHHGVFAFLVSPSPYELCAVP  474
            MELFLF TS+LQ+F+  S+   +   +   V  F   P  Y+LC +P
Sbjct  416  MELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIP  462

Hit Number: 35, Accession Number: 3C6G_A
pdb|3C6G|A Chain A, Cytochrome P450 2R1 [Homo sapiens]
Length = 479, Score = 337 bits (865), Expect = 9e-111,
Identities = 184/442 (42%), Positives = 249/442 (56%), Gaps = 14/442 (3%)
Query  43   FGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARY  102
            +G++FSL L     VVLNG   V+E LV   E  ADRP +P+   +    +  G+  +RY
Sbjct  47   YGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKM---TKMGGLLNSRY  103

Query  103  GPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSN  162
            G  W + RR +V++ R  G G+KS E  + EE      A   + GRPF    L+  AVSN
Sbjct  104  GRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSN  163

Query  163  VIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVDRHIPALAGKVLRFQ  222
            +   +  G RF Y+D  F  +++L  E ++  +     + NA P    +P    + L   
Sbjct  164  ITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRN  223

Query  223  KAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFS  282
             A +      L E        Q P+   +A+L EM++ K +P S+F+ ENL   V +L  
Sbjct  224  AAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELII  283

Query  283  AGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQ  342
            AG  TT+  L W +L M L+P++Q +VQ+EID ++G   +P   D+  MPYT AV+HEV 
Sbjct  284  AGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVL  343

Query  343  RFGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQ  402
            RF +IVPLG+ H TS D  V+G+ IPKGTT+ITNL SV  DE  W  P  FHPE FLD+ 
Sbjct  344  RFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSS  403

Query  403  GHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFS-----VPTGQPRPSHHG  457
            G+F K EA +PFS GRR CLGE LARME+FLFFT+LLQ F        VP  +PR     
Sbjct  404  GYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPR-----  458

Query  458  VFAFLVSPSPYELCAVPRHHHH  479
                 + P PY +CA  RHHHH
Sbjct  459  -LGMTLQPQPYLICAERRHHHH  479

Hit Number: 36, Accession Number: 5E0E_A
pdb|5E0E|A Chain A, Cytochrome P450 family 2 subfamily B [Neotoma lepida]
Length = 463, Score = 335 bits (859), Expect = 5e-110,
Identities = 186/460 (40%), Positives = 265/460 (58%), Gaps = 17/460 (4%)
Query  23   NLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPV  82
            NLL +D       F ++R ++GDVF++ L   PVV+L G  A+REALV   E  + R  +
Sbjct  14   NLLQMDRGGFLNSFRRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSGRGTI  73

Query  83   PITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAF  142
             + + +    R  GV  A  G  W+  RRFS+ T+R+ G+GK+S+E+ + EEA CL   F
Sbjct  74   AVVEPIF---RGYGVVFAN-GERWKALRRFSLVTMRDFGMGKRSVEERIQEEARCLVEEF  129

Query  143  ANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVL  202
                G P  P  L     +N+I S+  G RF+Y D +FLRLL L  +     S F  +V 
Sbjct  130  RKSQGAPLDPTFLFQCITANIICSIVFGERFDYKDHQFLRLLYLFYQSFSLISSFSSQVF  189

Query  203  NAVP-VDRHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAK  261
                   ++ P    ++ R  +  L  + + + +HR T DP+ P RD  + +L  MEK K
Sbjct  190  ELFSGFLKYFPGTHRQISRNLQEILDYIGQSVEKHRATLDPSHP-RDFIDTYLLRMEKEK  248

Query  262  GNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVR  321
             N  + F+ +NL I V  LF AG  T+STTL +G LLM+ +P V  +VQ+EID VIG  R
Sbjct  249  SNQHTEFDHQNLVISVLSLFFAGTETSSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSHR  308

Query  322  RPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVL  381
             P + D+  MPYT AVI+E+QRF D++P+G+ H  ++D   +G+ +PK T +   LSS L
Sbjct  309  LPTLEDRTKMPYTEAVIYEIQRFSDLIPIGVPHKVTKDTLFRGYLLPKNTEVYPILSSAL  368

Query  382  KDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQH  441
             D   +E+P  F+P+HFLDA G   K EAF+PFS G+R CLGE +AR ELFLFFT++LQ+
Sbjct  369  HDPQYFEQPDTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQN  428

Query  442  FSFSVPTG------QPRPSHHGVFAFLVSPSPYELCAVPR  475
            FS S P         P+ S  G       P  Y++C + R
Sbjct  429  FSLSSPVAPKDIDLSPKESGFGKV-----PQTYQICFLAR  463

Hit Number: 37, Accession Number: 5E58_A
pdb|5E58|A Chain A, Cytochrome P450 family 2 subfamily B [Neotoma lepida]
Length = 493, Score = 335 bits (859), Expect = 9e-110,
Identities = 185/462 (40%), Positives = 264/462 (57%), Gaps = 17/462 (4%)
Query  23   NLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPV  82
            NLL +D       F ++R ++GDVF++ L   PVV+L G  A+REALV   E  + R  +
Sbjct  42   NLLQMDRGGFLNSFMRIREKYGDVFTVHLGPRPVVMLYGTEAIREALVDQAEAFSGRGTI  101

Query  83   PITQ-ILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAA  141
             + + ++G      G+  +  G  W+  RRFS++T+R+ G+GK+S+E  + EEA CL   
Sbjct  102  AVIKPVIG----DYGMIFSN-GERWKVLRRFSLATMRDFGMGKRSVEDRIQEEAQCLVEE  156

Query  142  FANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREV  201
                 G P  P  L     +N+I S+  G R++Y D +FLRLLDL        S F  +V
Sbjct  157  LQKSQGAPLDPTFLFQCITANIICSIVFGERYDYKDRQFLRLLDLFYRTFSLMSSFSSQV  216

Query  202  LNAVP-VDRHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKA  260
                    ++ P    ++ R  +  L  + + + +HR T DP+ P RD  + +L  MEK 
Sbjct  217  FELFSGFMKYFPGAHRQITRNLQEILDYVGQSVEKHRATLDPSNP-RDFIDTYLLRMEKE  275

Query  261  KGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQV  320
            K N  + F+ +NL I V  LF AG  TTSTTL +G LLM+ +P V  +VQ+EID VIG  
Sbjct  276  KSNQHTEFHHQNLLISVLSLFFAGTETTSTTLRYGFLLMLKYPHVAEKVQKEIDQVIGSH  335

Query  321  RRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSV  380
            R P + D+  MPYT AVIHE+QRF D+ P+G  H  ++D   +G+ +PK T +   LSS 
Sbjct  336  RLPTLEDRTKMPYTDAVIHEIQRFSDLAPIGAPHKVTKDTLFRGYLLPKNTEVYPILSSA  395

Query  381  LKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQ  440
            L D   +E+P  F+P+HFLDA G   K EAF+PFS G+R CLGE +AR ELFLFFT++LQ
Sbjct  396  LHDPQYFEQPGTFNPDHFLDANGALKKSEAFMPFSIGKRICLGEGIARNELFLFFTTILQ  455

Query  441  HFSFSVPTGQPR-----PSHHGVFAFLVSPSPYELCAVPRHH  477
            +FS S     P+     P   G+      P  Y++  + RHH
Sbjct  456  NFSVSSSVA-PKDIDLSPKESGIGKV---PQTYQISFLARHH  493

Hit Number: 38, Accession Number: 3CZH_A
pdb|3CZH|A Chain A, Cytochrome P450 2R1 [Homo sapiens]
Length = 481, Score = 326 bits (836), Expect = 2e-106,
Identities = 180/438 (41%), Positives = 245/438 (56%), Gaps = 14/438 (3%)
Query  43   FGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARY  102
            +G++FSL L     VVLNG   V+E LV   E  ADRP +P+   +    +  G+  +RY
Sbjct  47   YGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKM---TKMGGLLNSRY  103

Query  103  GPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSN  162
            G  W + RR +V++ R  G G+KS E  + EE      A   + GRPF    L+  AVSN
Sbjct  104  GRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSN  163

Query  163  VIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVDRHIPALAGKVLRFQ  222
            +   +  G RF Y+D  F  +++L  E ++  +     + NA P    +P    + L   
Sbjct  164  ITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRN  223

Query  223  KAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFS  282
             A +      L E        Q P+   +A+L EM++ K +P S+F+ ENL   V +L  
Sbjct  224  AAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELII  283

Query  283  AGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQ  342
            AG  TT+  L W +L M L+P++Q +VQ+EID ++G   +P   D+  MPYT AV+HEV 
Sbjct  284  AGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVL  343

Query  343  RFGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQ  402
            RF +IVPLG+ H TS D  V+G+ IPKGTT+ITNL SV  DE  W  P  FHPE FLD+ 
Sbjct  344  RFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSS  403

Query  403  GHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFS-----VPTGQPRPSHHG  457
            G+F K EA +PFS GRR CLGE LARME+FLFFT+LLQ F        VP  +PR     
Sbjct  404  GYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPR-----  458

Query  458  VFAFLVSPSPYELCAVPR  475
                 + P PY +CA  R
Sbjct  459  -LGMTLQPQPYLICAERR  475

Hit Number: 39, Accession Number: 6OYU_A
pdb|6OYU|A Chain A, Cytochrome P450 1B1 [synthetic construct]
Length = 493, Score = 263 bits (671), Expect = 1e-81,
Identities = 173/463 (37%), Positives = 245/463 (53%), Gaps = 27/463 (6%)
Query  1    MAKKTSSK-GKLPPGPLPLPGLGNLLHVDFQNTPY-CFDQLRRRFGDVFSLQLAWTPVVV  58
            MAKKTSS+ G  PPGP P P +GN   V   + P+  F +L RR+GDVF ++L   PVVV
Sbjct  1    MAKKTSSQPGSRPPGPFPWPLIGNAAEVG--SAPHLSFARLARRYGDVFQIRLGSCPVVV  58

Query  59   LNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLR  118
            LNG  A+R+ALV  G   A RPP P  Q++  G   + +   RY   W+ QRR + ST+R
Sbjct  59   LNGERAIRQALVQQGAAFAGRPPFPSFQVVSGG---RSLAFGRYSERWKVQRRVAHSTVR  115

Query  119  NLGLG----KKSLEQWVTEEAACLCAAFANHS--GRPFRPNGLLDKAVSNVIASLTCGRR  172
                G    ++ LEQ V  EA  L       S  G    P  L   AV+NV++++  G R
Sbjct  116  AFSTGQPRSRRVLEQHVLGEARELVRLLVRGSAGGAFLDPAPLTVVAVANVMSAVCFGCR  175

Query  173  FEYDDPRFLRLLDLAQE-GLKEESGFLREVLNAVPVDRHIPALAGKVLR----FQKAFLT  227
            + +DD  F  LL   ++ G    +G L +VL   P  +  P       R      + F +
Sbjct  176  YSHDDAEFRGLLSHNEKFGRTVGAGSLVDVL---PWLQRFPNPVRTAFRDFQQLNRDFYS  232

Query  228  QLDELLTEHRMTWDPAQPPRDLTEAFLAEM--EKAKGNPESS--FNDENLRIVVADLFSA  283
             + +    HR +  P   PRD+ +AF+  +  E+A+GN +S    + E +   V D+F A
Sbjct  233  FVLDKFLRHRSSLRPGAAPRDMMDAFIHTVGKEEAEGNGDSGPRLDLEYVPATVTDIFGA  292

Query  284  GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQR  343
               T ST L W L+L   +P+VQ RVQ+E+D V+G+ R P M DQ H+PY  A ++E  R
Sbjct  293  SQDTLSTALQWLLILFTRYPEVQARVQEELDRVVGRDRLPCMDDQPHLPYVMAFLYEAMR  352

Query  344  FGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQG  403
            F   VP+ + H T+ D  + G+ IPK T +  N  SV  D   W  P  F+P  FLD  G
Sbjct  353  FSSFVPVTIPHATTADTSIMGYHIPKDTVVFVNQWSVNHDPVKWPNPEDFNPARFLDKNG  412

Query  404  HFVK--PEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSF  444
               K    + + FS G+R C+GE L++M+LFLF + L    +F
Sbjct  413  FINKDLASSVMIFSVGKRRCIGEELSKMQLFLFISILAHQCNF  455

Hit Number: 40, Accession Number: 3PM0_A
pdb|3PM0|A Chain A, Cytochrome P450 1B1 [Homo sapiens]
Length = 507, Score = 254 bits (650), Expect = 2e-78,
Identities = 175/492 (36%), Positives = 245/492 (50%), Gaps = 26/492 (5%)
Query  1    MAKKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLN  60
            MAKKTSSKGK PPGP   P +GN   V  Q     F +L RR+GDVF ++L   P+VVLN
Sbjct  1    MAKKTSSKGK-PPGPFAWPLIGNAAAVG-QAAHLSFARLARRYGDVFQIRLGSCPIVVLN  58

Query  61   GLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNL  120
            G  A+ +ALV  G   ADRP     +++  G RS       Y   W+ QRR + S +RN 
Sbjct  59   GERAIHQALVQQGSAFADRPSFASFRVVS-GGRSMA--FGHYSEHWKVQRRAAHSMMRNF  115

Query  121  GL----GKKSLEQWVTEEAACLCAAFANHS--GRPFRPNGLLDKAVSNVIASLTCGRRFE  174
                   ++ LE  V  EA  L A     S  G    P  L   AV+NV++++  G R+ 
Sbjct  116  FTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYS  175

Query  175  YDDPRFLRLLDLAQE-GLKEESGFLREVLNAVPVDRHIPALAGKVLR----FQKAFLTQL  229
            +DDP F  LL   +E G    +G L +V+   P  ++ P     V R      + F   +
Sbjct  176  HDDPEFRELLSHNEEFGRTVGAGSLVDVM---PWLQYFPNPVRTVFREFEQLNRNFSNFI  232

Query  230  DELLTEHRMTWDPAQPPRDLTEAFLAEMEK-AKGNPE---SSFNDENLRIVVADLFSAGM  285
             +    H  +  P   PRD+ +AF+   EK A G+     +  + EN+   + D+F A  
Sbjct  233  LDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDLENVPATITDIFGASQ  292

Query  286  VTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFG  345
             T ST L W LLL   +PDVQ RVQ E+D V+G+ R P MGDQ ++PY  A ++E  RF 
Sbjct  293  DTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFS  352

Query  346  DIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHF  405
              VP+ + H T+ +  V G+ IPK T +  N  SV  D   W  P  F P  FLD  G  
Sbjct  353  SFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARFLDKDGLI  412

Query  406  VK--PEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLV  463
             K      + FS G+R C+GE L++M+LFLF + L     F     +P   +   +   +
Sbjct  413  NKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQCDFRANPNEPAKMNFS-YGLTI  471

Query  464  SPSPYELCAVPR  475
             P  +++    R
Sbjct  472  KPKSFKVNVTLR  483

Hit Number: 41, Accession Number: 4I8V_A
pdb|4I8V|A Chain A, Cytochrome P450 1A1 [Homo sapiens]
Length = 491, Score = 252 bits (644), Expect = 1e-77,
Identities = 155/465 (33%), Positives = 251/465 (54%), Gaps = 23/465 (5%)
Query  1    MAKKTSSKG-KLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVL  59
            MAKKTSSKG K PPGP   P +G++L +  +N      ++ +++GDV  +++  TPVVVL
Sbjct  1    MAKKTSSKGLKNPPGPWGWPLIGHMLTLG-KNPHLALSRMSQQYGDVLQIRIGSTPVVVL  59

Query  60   NGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRN  119
            +GL  +R+ALV  G+D   RP +    ++  G      F    GP W  +RR + + L++
Sbjct  60   SGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMS--FSPDSGPVWAARRRLAQNGLKS  117

Query  120  LGLGKK-------SLEQWVTEEAACLCAAFANHSGRP--FRPNGLLDKAVSNVIASLTCG  170
              +           LE+ V++EA  L +        P  F P   +  +V+NVI ++  G
Sbjct  118  FSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFG  177

Query  171  RRFEYDDPRFLRLLDLAQE-GLKEESGFLREVLNAVPVDRHIPALAGKVLR-FQKAFLTQ  228
            RR++++    L L++L    G    SG      + +P+ R++P  +    +   + F + 
Sbjct  178  RRYDHNHQELLSLVNLNNNFGEVVGSG---NPADFIPILRYLPNPSLNAFKDLNEKFYSF  234

Query  229  LDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAK--GNPESSFNDENLRIVVADLFSAGMV  286
            + +++ EH  T++     RD+T++ +   ++ +   N     +DE +  +V DLF AG  
Sbjct  235  MQKMVKEHYKTFEKGHI-RDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFD  293

Query  287  TTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGD  346
            T +T ++W L+ ++++P VQR++Q+E+D VIG+ RRP + D++H+PY  A I E  R   
Sbjct  294  TVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSS  353

Query  347  IVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFV  406
             VP  + H T+RD  ++GF IPKG  +  N   +  D+ +W  P  F PE FL   G   
Sbjct  354  FVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAID  413

Query  407  K--PEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG  449
            K   E  + F  G+R C+GE +AR E+FLF   LLQ   FSVP G
Sbjct  414  KVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLG  458

Hit Number: 42, Accession Number: 6B82_A
pdb|6B82|A Chain A, Cytochrome P450, family 17, subfamily A, polypeptide 1 [Danio rerio]
Length = 509, Score = 249 bits (636), Expect = 3e-76,
Identities = 158/502 (31%), Positives = 256/502 (51%), Gaps = 38/502 (8%)
Query  1    MAKKTSSKGKL-------------PPGPLPLPGLGNLLHVDFQNTPYCFDQ-LRRRFGDV  46
            MAKKTSSKGK              PP    LP +G+L+ +   + P+ F Q L++++GD+
Sbjct  1    MAKKTSSKGKKQKMNGFVPAGNRSPPSLPSLPIIGSLMSLVSDSPPHIFFQDLQKKYGDL  60

Query  47   FSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAW  106
            +SL +    ++++N     +E L+  G+  A RP    T +L    +   +  A Y   W
Sbjct  61   YSLMMGSHKLLIVNNHHHAKEILIKKGKIFAGRPRTVTTDLLTRDGKD--IAFADYSSTW  118

Query  107  REQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIAS  166
            +  R+     L   G G  S+E+ +  EA+ +C                L +AV+NV+ +
Sbjct  119  KFHRKMVHGALCMFGEGSVSIEKIICREASSMCEVLTESQNSAVDLGPELTRAVTNVVCA  178

Query  167  LTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVDRH--IPALAGKVLRFQKA  224
            L     ++  D  F  +L  +Q       G +  V     VD    +     K LR  + 
Sbjct  179  LCFNSSYKRGDAEFESMLQYSQ-------GIVDTVAKDSLVDIFPWLQIFPNKDLRILRQ  231

Query  225  FLTQLDELLT----EHRMTW-DPAQPPRDLTEAFLAEMEKAKGNPESS----FNDENLRI  275
             ++  D+LL     EH++T+ D  Q  RDL +A L     ++ N  S+      ++++ +
Sbjct  232  CISIRDKLLQKKYEEHKVTYSDNVQ--RDLLDALLRAKRSSENNNSSTRDVGLTEDHVLM  289

Query  276  VVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTT  335
             V ++F AG+ TT+TTL W +  ++ +P VQR++Q+E+D  IG+ R P++ D+ ++PY  
Sbjct  290  TVGEIFGAGVETTTTTLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPYLE  349

Query  336  AVIHEVQRFGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHP  395
            A I EV R   + PL + H+  +D  V  + + KGT ++ N+ S+  DE  W+ P  F P
Sbjct  350  ATICEVMRIRPVSPLLIPHVALQDSSVGEYTVQKGTRVVINMWSLHHDEKEWKNPELFDP  409

Query  396  EHFLDAQGH-FVKPE-AFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRP  453
              FL+ +G     P  ++LPF AG R CLGE LA+MELFLF   +LQ F+  +PTGQP P
Sbjct  410  GRFLNEEGDGLCCPSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQPLP  469

Query  454  SHHGVFAFLVSPSPYELCAVPR  475
               G F  ++ P  +++ A  R
Sbjct  470  DLQGKFGVVLQPKKFKVVAKVR  491

Hit Number: 43, Accession Number: 4R20_A
pdb|4R20|A Chain A, Cytochrome P450 family 17 polypeptide 2 [Danio rerio]
Length = 486, Score = 242 bits (618), Expect = 7e-74,
Identities = 160/490 (33%), Positives = 243/490 (50%), Gaps = 26/490 (5%)
Query  1    MAKKTSSKGKLPPGP-------LPLPGLGNLLHVDFQNTP--YCFDQLRRRFGDVFSLQL  51
            MAKKTSSKGK   G        LP   L   L     N P    F QL  ++G +F L  
Sbjct  1    MAKKTSSKGKEGVGSSSVSFPCLPRLPLLGSLLHLRSNLPPHLLFTQLSSQYGPLFGLYA  60

Query  52   AWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRR  111
                 +V++ +  VRE L+  G + A RP +  T +L  G   + +  A Y P W+  RR
Sbjct  61   GPHLTLVVSEIGLVREVLLQRGREFAGRPKMVTTDLLTQG--GKDIAFADYSPLWKNHRR  118

Query  112  FSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGR  171
               S+    G G   L+  V E A  LC       G+    + +L +AV+NVI  L    
Sbjct  119  LVHSSFTLFGEGSNKLQTIVQEAADSLCEELQACRGQSSDLSVVLMRAVTNVICRLVFSS  178

Query  172  RFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVDRH--IPALAGKVLRFQKAFLTQL  229
             ++  DP         Q  ++   G ++ +     VD    +     K L+  K  ++  
Sbjct  179  SYQPSDPEL-------QTVIQYNDGIVQTIARGGLVDIFPWLRIFPNKDLKRLKECVSIR  231

Query  230  DELL----TEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGM  285
            D+LL     EH+ +  P +P RDL +A L   ++  G  +    ++++ +  A+ F AG+
Sbjct  232  DQLLYKKLLEHKKSLTPGEP-RDLLDALLIGQQRGSGGADD-ITEDHVLMTAAEAFGAGV  289

Query  286  VTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFG  345
             TTSTTL W +  ++ HP +Q RVQ E+D+ +G  R P + D+ H+P   AV+ EV R  
Sbjct  290  ETTSTTLLWTIAFLLHHPQLQERVQAELDECVGVDRPPCLSDRPHLPLLDAVLCEVMRIR  349

Query  346  DIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHF  405
             + P+ + H+  +D  + G  +PKGT ++ N+ ++  D   W++P +F+PE FL+  G  
Sbjct  350  PVSPILIPHVAMQDTSLGGHSVPKGTRVLVNMWAIHHDPKHWDQPEQFNPERFLEPSGKK  409

Query  406  VKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSP  465
                +FLPF AG R C+GE LAR+ELFLF +  LQ FSFS P+    P   G F  ++ P
Sbjct  410  KTQSSFLPFGAGPRVCVGESLARIELFLFVSRPLQRFSFSCPSEASLPDLQGRFGVVLQP  469

Query  466  SPYELCAVPR  475
              Y +   PR
Sbjct  470  ERYTVTVTPR  479

Hit Number: 44, Accession Number: 6IQ5_A
pdb|6IQ5|A Chain A, Cytochrome P450 1B1 [Homo sapiens]
Length = 463, Score = 230 bits (587), Expect = 1e-69,
Identities = 156/457 (34%), Positives = 225/457 (49%), Gaps = 24/457 (5%)
Query  36   FDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQ  95
            F +L RR+GDVF ++L   P+VVLNG  A+ +ALV  G   ADRP     +++  G RS 
Sbjct  7    FARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPSFASFRVVS-GGRSM  65

Query  96   GVFLARYGPAWREQRRFSVSTLRNLGL----GKKSLEQWVTEEAACLCAAFANHS--GRP  149
                  Y   W+ QRR + S +RN        ++ LE  V  EA  L A     S  G  
Sbjct  66   A--FGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAF  123

Query  150  FRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQE-GLKEESGFLREVLNAVPVD  208
              P  L   AV+NV++++  G R+ +DDP F  LL   +E G    +G L +V+   P  
Sbjct  124  LDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSLVDVM---PWL  180

Query  209  RHIPALAGKVLR----FQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEK-AKGN  263
            ++ P     V R      + F   + +    H  +  P   PRD+ +AF+   EK A G+
Sbjct  181  QYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGD  240

Query  264  PE---SSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQV  320
                 +  + EN+   + D+F A   T ST L W LLL   +PDVQ RVQ E+D V+G+ 
Sbjct  241  SHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRD  300

Query  321  RRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSV  380
            R P MGDQ ++PY  A ++E  RF   VP+ + H T+ +  V G+ IPK T +  N  SV
Sbjct  301  RLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSV  360

Query  381  LKDEAVWEKPFRFHPEHFLDAQGHFVK--PEAFLPFSAGRRACLGEPLARMELFLFFTSL  438
              D   W  P  F P  FLD  G   K      + FS G+R C+GE L++M+LFLF + L
Sbjct  361  NHDPVKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISIL  420

Query  439  LQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR  475
                 F     +P   +   +   + P  +++    R
Sbjct  421  AHQCDFRANPNEPAKMNFS-YGLTIKPKSFKVNVTLR  456

Hit Number: 45, Accession Number: 2HI4_A
pdb|2HI4|A Chain A, Cytochrome P450 1A2 [Homo sapiens]
Length = 495, Score = 229 bits (585), Expect = 6e-69,
Identities = 149/456 (33%), Positives = 231/456 (51%), Gaps = 25/456 (5%)
Query  10   KLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREAL  69
            K PP P   P LG++L +  +N      ++ +R+GDV  +++  TPV+VL+ L  +R+AL
Sbjct  16   KSPPEPWGWPLLGHVLTLG-KNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQAL  74

Query  70   VTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKK----  125
            V  G+D   RP +  + ++  G      F    GP W  +RR + + L    +       
Sbjct  75   VRQGDDFKGRPDLYTSTLITDG--QSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASS  132

Query  126  ---SLEQWVTEEAACLCAAFANHSGRP--FRPNGLLDKAVSNVIASLTCGRRFEYDDPRF  180
                LE+ V++EA  L +        P  F P   +  +V+NVI ++  G+ F       
Sbjct  133  SSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEM  192

Query  181  LRLLDLAQEGLKEESGFLREVLNAVPVDRHIPALAGKVLR-FQKAFLTQLDELLTEHRMT  239
            L L+    E ++  S      L+  P+ R++P  A +  + F + FL  L + + EH   
Sbjct  193  LSLVKNTHEFVETASS--GNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQD  250

Query  240  WDPAQPPRDLTEAFLAEMEKAKGNPESSFN---DENLRIVVADLFSAGMVTTSTTLAWGL  296
            +D     RD+T A     + +K  P +S N    E +  +V D+F AG  T +T ++W L
Sbjct  251  FD-KNSVRDITGALF---KHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSL  306

Query  297  LLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMT  356
            + ++  P++QR++Q+E+D VIG+ RRP + D+  +PY  A I E  R    +P  + H T
Sbjct  307  MYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHST  366

Query  357  SRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFV-KP--EAFLP  413
            +RD  + GF IPK   +  N   V  D  +WE P  F PE FL A G  + KP  E  + 
Sbjct  367  TRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMML  426

Query  414  FSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG  449
            F  G+R C+GE LA+ E+FLF   LLQ   FSVP G
Sbjct  427  FGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPG  462

Hit Number: 46, Accession Number: 4R1Z_A
pdb|4R1Z|A Chain A, Cyp17a1 protein [Danio rerio]
Length = 439, Score = 214 bits (546), Expect = 9e-64,
Identities = 133/433 (31%), Positives = 217/433 (50%), Gaps = 24/433 (6%)
Query  56   VVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVS  115
            ++++N     +E L+  G+  A RP    T +L    +   +  A Y   W+  R+    
Sbjct  6    LLIVNNHHHAKEILIKKGKIFAGRPRTVTTDLLTRDGKD--IAFADYSSTWKFHRKMVHG  63

Query  116  TLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEY  175
             L   G G  S+E+ +  EA+ +C                L +AV+NV+ +L     ++ 
Sbjct  64   ALCMFGEGSVSIEKIICREASSMCEVLTESQNSAVDLGPELTRAVTNVVCALCFNSSYKR  123

Query  176  DDPRFLRLLDLAQEGLKEESGFLREVLNAVPVDRH--IPALAGKVLRFQKAFLTQLDELL  233
             D  F  +L  +Q       G +  V     VD    +     K L   +  ++  D+LL
Sbjct  124  GDAEFESMLQYSQ-------GIVDTVAKDSLVDIFPWLQIFPNKDLTILRQCISIRDKLL  176

Query  234  T----EHRMTW-DPAQPPRDLTEAFLAEMEKAKGNPESS----FNDENLRIVVADLFSAG  284
                 EH++T+ D  Q  RDL +A L     ++ N  S+      ++++ + V D+F AG
Sbjct  177  QKKYEEHKVTYSDNVQ--RDLLDALLRAKRSSENNNSSTRDVGLTEDHVLMTVGDIFGAG  234

Query  285  MVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRF  344
            + TT+T L W +  ++ +P VQR++Q+E+D  IG+ R P++ D+ ++PY  A I EV R 
Sbjct  235  VETTTTVLKWSIAYLVHNPQVQRKIQEELDSKIGKERHPQLSDRGNLPYLEATIREVLRI  294

Query  345  GDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGH  404
              + PL + H+  +D  V  + + KGT ++ NL S+  D+  W+ P  F P  FL+ +G 
Sbjct  295  RPVSPLLIPHVALQDSSVGEYTVQKGTRVVINLWSLHHDKKEWKNPELFDPGRFLNEEGD  354

Query  405  -FVKPE-AFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFL  462
                P  ++LPF AG R CLGE LA+MELFLF   +LQ F+  +PTGQP P   G F  +
Sbjct  355  GLCCPSGSYLPFGAGVRVCLGEALAKMELFLFLAWILQRFTLEMPTGQPLPDLQGKFGVV  414

Query  463  VSPSPYELCAVPR  475
            + P  +++ A  R
Sbjct  415  LQPKKFKVVAKVR  427

Hit Number: 47, Accession Number: 5VBU_A
pdb|5VBU|A Chain A, Cytochrome P450 21-hydroxylase [Homo sapiens]
Length = 476, Score = 200 bits (508), Expect = 7e-58,
Identities = 153/468 (33%), Positives = 227/468 (49%), Gaps = 40/468 (9%)
Query  1    MAKKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLN  60
            MAKKTSSKGKLPP     PG  +LL  D    P     L ++FG ++ L L    VVVLN
Sbjct  1    MAKKTSSKGKLPPLA---PGFLHLLQPDL---PIYLLGLTQKFGPIYRLHLGLQDVVVLN  54

Query  61   GLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNL  120
                + EA+V    D A RP  P+T  L        + L  Y   W+  ++ + S L  L
Sbjct  55   SKRTIEEAMVKKWADFAGRPE-PLTYKL-VSRNYPDLSLGDYSLLWKAHKKLTRSALL-L  111

Query  121  GLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD--P  178
            G+ + S+E  V +     C       G P            ++I  LT G + + D+  P
Sbjct  112  GI-RDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIKDDNLMP  170

Query  179  RFLRLLDLAQEGLKEESGFLREVLNAVPVDRHIPALAGKVLRFQKAFLTQLDEL----LT  234
             + + +   QE LK  S +  ++++ +P  R  P      LR  K  + + D +    L 
Sbjct  171  AYYKCI---QEVLKTWSHWSIQIVDVIPFLRFFP---NPGLRRLKQAIEKRDHIVEMQLR  224

Query  235  EHRMTWDPAQPPRDLTEAFLA-----EMEKAKGNPESSFNDENLRIVVADLFSAGMVTTS  289
            +H+ +    Q  RD+ +  L       ME+  G       + ++ +   DL   G  TT+
Sbjct  225  QHKESLVAGQW-RDMMDYMLQGVAQPSMEEGSGQ----LLEGHVHMAAVDLLIGGTETTA  279

Query  290  TTLAWGLLLMILHPDVQRRVQQEIDDVIG---QVRRPEMGDQAHMPYTTAVIHEVQRFGD  346
             TL+W ++ ++ HP++Q+R+Q+E+D  +G      R    D+A +P   A I EV R   
Sbjct  280  NTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRP  339

Query  347  IVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFV  406
            +VPL + H T+R   + G+ IP+GT +I NL     DE VWE+P  F P+ FL+      
Sbjct  340  VVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPG----  395

Query  407  KPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPS  454
            K    L F  G R CLGEPLAR+ELF+  T LLQ F+  +P+G   PS
Sbjct  396  KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTL-LPSGDALPS  442

Hit Number: 48, Accession Number: 4Y8W_A
pdb|4Y8W|A Chain A, Cytochrome P450 21-hydroxylase [Homo sapiens]
Length = 482, Score = 200 bits (508), Expect = 7e-58,
Identities = 153/468 (33%), Positives = 227/468 (49%), Gaps = 40/468 (9%)
Query  1    MAKKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLN  60
            MAKKTSSKGKLPP     PG  +LL  D    P     L ++FG ++ L L    VVVLN
Sbjct  1    MAKKTSSKGKLPPLA---PGFLHLLQPDL---PIYLLGLTQKFGPIYRLHLGLQDVVVLN  54

Query  61   GLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNL  120
                + EA+V    D A RP  P+T  L        + L  Y   W+  ++ + S L  L
Sbjct  55   SKRTIEEAMVKKWADFAGRPE-PLTYKL-VSRNYPDLSLGDYSLLWKAHKKLTRSALL-L  111

Query  121  GLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD--P  178
            G+ + S+E  V +     C       G P            ++I  LT G + + D+  P
Sbjct  112  GI-RDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIKDDNLMP  170

Query  179  RFLRLLDLAQEGLKEESGFLREVLNAVPVDRHIPALAGKVLRFQKAFLTQLDEL----LT  234
             + + +   QE LK  S +  ++++ +P  R  P      LR  K  + + D +    L 
Sbjct  171  AYYKCI---QEVLKTWSHWSIQIVDVIPFLRFFP---NPGLRRLKQAIEKRDHIVEMQLR  224

Query  235  EHRMTWDPAQPPRDLTEAFLA-----EMEKAKGNPESSFNDENLRIVVADLFSAGMVTTS  289
            +H+ +    Q  RD+ +  L       ME+  G       + ++ +   DL   G  TT+
Sbjct  225  QHKESLVAGQW-RDMMDYMLQGVAQPSMEEGSGQ----LLEGHVHMAAVDLLIGGTETTA  279

Query  290  TTLAWGLLLMILHPDVQRRVQQEIDDVIG---QVRRPEMGDQAHMPYTTAVIHEVQRFGD  346
             TL+W ++ ++ HP++Q+R+Q+E+D  +G      R    D+A +P   A I EV R   
Sbjct  280  NTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRP  339

Query  347  IVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFV  406
            +VPL + H T+R   + G+ IP+GT +I NL     DE VWE+P  F P+ FL+      
Sbjct  340  VVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPG----  395

Query  407  KPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPS  454
            K    L F  G R CLGEPLAR+ELF+  T LLQ F+  +P+G   PS
Sbjct  396  KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTL-LPSGDALPS  442

Hit Number: 49, Accession Number: 4NKV_A
pdb|4NKV|A Chain A, Steroid 17-alpha-hydroxylase/17,20 lyase [Homo sapiens]
Length = 494, Score = 197 bits (500), Expect = 1e-56,
Identities = 139/503 (28%), Positives = 240/503 (48%), Gaps = 33/503 (7%)
Query  1    MAKKTSSKGKLPPGPLPLPGLGNL----LHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPV  56
            MAKKT +K   P   L LP +G+L     H    N    F +L++++G ++S+++     
Sbjct  1    MAKKTGAK--YPKSLLSLPLVGSLPFLPRHGHMHNN---FFKLQKKYGPIYSVRMGTKTT  55

Query  57   VVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVST  116
            V++      +E L+  G+D + RP +    IL      +G+  A  G  W+  RR +++T
Sbjct  56   VIVGHHQLAKEVLIKKGKDFSGRPQMATLDILS--NNRKGIAFADSGAHWQLHRRLAMAT  113

Query  117  LRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYD  176
                  G + LE+ + +E + LC   A H+G+    +  +  AV+NVI+ +     ++  
Sbjct  114  FALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNG  173

Query  177  DPRFLRLLDLAQEGLKEESGFLREVLNAVPVDRHIPALAGKVLRFQKAFLTQL-DELLTE  235
            DP  L ++    EG+ +       +++ VP  +  P    + L+        L +++L  
Sbjct  174  DPE-LNVIQNYNEGIIDNLS-KDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILEN  231

Query  236  HRMTWDPAQPPRDLTEAFLAEMEKAKGN--PESS---FNDENLRIVVADLFSAGMVTTST  290
            ++  +        L     A+M    GN  P+      +D ++   + D+F AG+ TT++
Sbjct  232  YKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTS  291

Query  291  TLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPL  350
             + W L  ++ +P V++++ +EID  +G  R P + D+  +    A I EV R   + P+
Sbjct  292  VVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPM  351

Query  351  GMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQG-HFVKPE  409
             + H  + D  +  F + KGT +I NL ++  +E  W +P +F PE FL+  G   + P 
Sbjct  352  LIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPS  411

Query  410  -AFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV--FAFLVSPS  466
             ++LPF AG R+C+GE LAR ELFL    LLQ F   VP     PS  G+    FL+   
Sbjct  412  VSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSF  471

Query  467  PYEL----------CAVPRHHHH  479
              ++               HHHH
Sbjct  472  KVKIKVRQAWREAQAEGSTHHHH  494

Hit Number: 50, Accession Number: 3RUK_A
pdb|3RUK|A Chain A, Steroid 17-alpha-hydroxylase/17,20 lyase [Homo sapiens]
Length = 494, Score = 195 bits (495), Expect = 8e-56,
Identities = 138/503 (27%), Positives = 239/503 (48%), Gaps = 33/503 (7%)
Query  1    MAKKTSSKGKLPPGPLPLPGLGNL----LHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPV  56
            MAKKT +K   P   L LP +G+L     H    N    F +L++++G ++S+++     
Sbjct  1    MAKKTGAK--YPKSLLSLPLVGSLPFLPRHGHMHNN---FFKLQKKYGPIYSVRMGTKTT  55

Query  57   VVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVST  116
            V++      +E L+  G+D + RP +    I       +G+  A  G  W+  RR +++T
Sbjct  56   VIVGHHQLAKEVLIKKGKDFSGRPQMATLDIAS--NNRKGIAFADSGAHWQLHRRLAMAT  113

Query  117  LRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYD  176
                  G + LE+ + +E + LC   A H+G+    +  +  AV+NVI+ +     ++  
Sbjct  114  FALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNG  173

Query  177  DPRFLRLLDLAQEGLKEESGFLREVLNAVPVDRHIPALAGKVLRFQKAFLTQL-DELLTE  235
            DP  L ++    EG+ +       +++ VP  +  P    + L+        L +++L  
Sbjct  174  DPE-LNVIQNYNEGIIDNLS-KDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILEN  231

Query  236  HRMTWDPAQPPRDLTEAFLAEMEKAKGN--PESS---FNDENLRIVVADLFSAGMVTTST  290
            ++  +        L     A+M    GN  P+      +D ++   + D+F AG+ TT++
Sbjct  232  YKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTS  291

Query  291  TLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPL  350
             + W L  ++ +P V++++ +EID  +G  R P + D+  +    A I EV R   + P+
Sbjct  292  VVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPM  351

Query  351  GMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQG-HFVKPE  409
             + H  + D  +  F + KGT +I NL ++  +E  W +P +F PE FL+  G   + P 
Sbjct  352  LIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPS  411

Query  410  -AFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV--FAFLVSPS  466
             ++LPF AG R+C+GE LAR ELFL    LLQ F   VP     PS  G+    FL+   
Sbjct  412  VSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSF  471

Query  467  PYEL----------CAVPRHHHH  479
              ++               HHHH
Sbjct  472  KVKIKVRQAWREAQAEGSTHHHH  494

Hit Number: 51, Accession Number: 6WR1_A
pdb|6WR1|A Chain A, Steroid 17-alpha-hydroxylase/17,20 lyase [Homo sapiens]
Length = 494, Score = 194 bits (493), Expect = 1e-55,
Identities = 139/503 (28%), Positives = 240/503 (48%), Gaps = 33/503 (7%)
Query  1    MAKKTSSKGKLPPGPLPLPGLGNL----LHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPV  56
            MAKKT +K   P   L LP +G+L     H    N  Y F +L++++G ++S+++     
Sbjct  1    MAKKTGAK--YPKSLLSLPLVGSLPFLPRHGHMHN--YFF-KLQKKYGPIYSVRMGTKTT  55

Query  57   VVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVST  116
            V++      +E L+  G+D + RP +    I       +G+  A  G  W+  RR +++T
Sbjct  56   VIVGHHQLAKEVLIKKGKDFSGRPQMATLDIAS--NNRKGIAFADSGAHWQLHRRLAMAT  113

Query  117  LRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYD  176
                  G + LE+ + +E + LC   A H+G+    +  +  AV+NVI+ +     ++  
Sbjct  114  FALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNG  173

Query  177  DPRFLRLLDLAQEGLKEESGFLREVLNAVPVDRHIPALAGKVLRFQKAFLTQL-DELLTE  235
            DP  L ++    EG+ +       +++ VP  +  P    + L+        L +++L  
Sbjct  174  DPE-LNVIQNYNEGIIDNLS-KDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILEN  231

Query  236  HRMTWDPAQPPRDLTEAFLAEMEKAKGN--PESS---FNDENLRIVVADLFSAGMVTTST  290
            ++  +        L     A+M    GN  P+      +D ++   + D+F AG+ TT++
Sbjct  232  YKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTS  291

Query  291  TLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPL  350
             + W L  ++ +P V++++ +EID  +G  R P + D+  +    A I EV R   + P+
Sbjct  292  VVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPM  351

Query  351  GMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQG-HFVKPE  409
             + H  + D  +  F + KGT +I NL ++  +E  W +P +F PE FL+  G   + P 
Sbjct  352  LIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPS  411

Query  410  -AFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV--FAFLVSPS  466
             ++LPF AG R+C+GE LAR ELFL    LLQ F   VP     PS  G+    FL+   
Sbjct  412  VSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSF  471

Query  467  PYEL----------CAVPRHHHH  479
              ++               HHHH
Sbjct  472  KVKIKVRQAWREAQAEGSTHHHH  494

Hit Number: 52, Accession Number: 3QZ1_A
pdb|3QZ1|A Chain A, Steroid 21-hydroxylase [Bos taurus]
Length = 496, Score = 187 bits (476), Expect = 4e-53,
Identities = 136/449 (30%), Positives = 218/449 (49%), Gaps = 29/449 (6%)
Query  19   PGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTAD  78
            P +   LH+   N P     L ++ G V+ L+L    VVVLN    + EA++    D A 
Sbjct  32   PLVPGFLHLLQPNLPIHLLSLTQKLGPVYRLRLGLQEVVVLNSKRTIEEAMIRKWVDFAG  91

Query  79   RPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACL  138
            RP +P  +++    R Q + L  Y   W+  ++ + S L  LG  + S+E WV +     
Sbjct  92   RPQIPSYKLVS--QRCQDISLGDYSLLWKAHKKLTRSALL-LG-TRSSMEPWVDQLTQEF  147

Query  139  CAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFL  198
            C      +G P            ++I  LT G +   +D       D  Q+ +K    + 
Sbjct  148  CERMRVQAGAPVTIQKEFSLLTCSIICYLTFGNK---EDTLVHAFHDCVQDLMKTWDHWS  204

Query  199  REVLNAVPVDRHIPALAGKVLRFQKAFLTQ---LDELLTEHRMTWDPAQPPRDLTEAFLA  255
             ++L+ VP  R  P     + R ++A   +   +++ L  H+ +    Q  RD+T+  L 
Sbjct  205  IQILDMVPFLRFFPNPG--LWRLKQAIENRDHMVEKQLRRHKESMVAGQW-RDMTDYMLQ  261

Query  256  EM--EKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEI  313
             +  ++ +  P     + ++ + V DLF  G  TT++TL+W +  ++ HP++QRR+Q+E+
Sbjct  262  GVGRQRVEEGP-GQLLEGHVHMSVVDLFIGGTETTASTLSWAVAFLLHHPEIQRRLQEEL  320

Query  314  DDVIG---QVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRDIEVQGFRIPKG  370
            D  +G      R    D+A +P   A I EV R   +VPL + H T+R   + G+ IP+G
Sbjct  321  DRELGPGASCSRVTYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIFGYDIPEG  380

Query  371  TTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARME  430
              +I NL     DE VWE+P  F P+ FL+   +   P A L F  G R CLGE LAR+E
Sbjct  381  MVVIPNLQGAHLDETVWEQPHEFRPDRFLEPGAN---PSA-LAFGCGARVCLGESLARLE  436

Query  431  LFLFFTSLLQHFSF------SVPTGQPRP  453
            LF+    LLQ F+       ++P+ QP P
Sbjct  437  LFVVLARLLQAFTLLPPPVGALPSLQPDP  465

Hit Number: 53, Accession Number: 9MS3_A
pdb|9MS3|A Chain A, Polybrominated aromatic compounds synthase [Marinomonas mediterranea]
Length = 495, Score = 139 bits (351), Expect = 2e-35,
Identities = 114/441 (26%), Positives = 189/441 (43%), Gaps = 48/441 (11%)
Query  38   QLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGV  97
             + +++G +++L+   T ++ LN   AVREALV   +    R  + I Q+    P+   +
Sbjct  48   NMAKKYGAIYALETGKTTLIALNDHNAVREALVNQSDVFNIRADLEILQV---APQKHFL  104

Query  98   FLARYGPAWREQRRFSVSTLRNLGLGK-KSLEQWVTEEAACLCAAFANHSGRP-FRPNGL  155
             L   G  W   R+   + +R+    +  +++QW+  E   + AA+ +   +  F PN  
Sbjct  105  EL-EAGELWSLHRKTFATAMRDYFRDRWDTMDQWLVTEIDDIEAAWKSQGDQAVFDPNRD  163

Query  156  LDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPV--------  207
            +   +++ +  +   RRF                G  EES F  + L+ +P         
Sbjct  164  ISIKLASFLHRVMFDRRF----------------GEFEESVFDEKSLSWLPAGFINSTRY  207

Query  208  -------DRHIPALAGKVLRFQKAFLTQLDELLT----EHRMTWDPAQPPRDLTEAFLAE  256
                        A  G V+    + L  LD  ++    + +  ++  Q  R LT+  L  
Sbjct  208  ELMPEHNKESYYAHYGDVIEKFASNLNGLDAYVSMNVLKEKECYNKGQY-RHLTDFLLNA  266

Query  257  MEKAKGNPESSFNDENLRIVVADLFSAGMVTTST---TLAWGLLLMILHPDVQRRVQQEI  313
             +    + +         I++  L              L W LL +   P+ Q++V  E+
Sbjct  267  CDDIPNDVKQQVGATEKEIIIGSLTQVAGAGGGVGAFALRWMLLYLASFPEKQKQVHAEL  326

Query  314  DDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPL-GMTHMTSRDIEVQGFRIPKGTT  372
            D VIGQ   P+   +  + YT A I EV R   I  +    +  S+D  + G+ + KGT 
Sbjct  327  DQVIGQNETPQQSHKGDLHYTQAFIAEVLRHCSITSMPASNYAASKDTFIDGYFVAKGTP  386

Query  373  LITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPE--AFLPFSAGRRACLGEPLARME  430
            LI N   + +DEA+WE P  F PE FL+A G F K +     PF  G+R CLGE   +  
Sbjct  387  LIVNNYGMTRDEALWENPDEFIPERFLEADGTFSKKQQAKSFPFGIGQRRCLGELFGKFL  446

Query  431  LFLFFTSLLQHFSFSVPTGQP  451
            +   FT L   F FS+P  +P
Sbjct  447  INTLFTHLAHRFEFSLPNNEP  467

Hit Number: 54, Accession Number: 7X2Q_A
pdb|7X2Q|A Chain A, Sugiol synthase [Salvia miltiorrhiza]
Length = 476, Score = 139 bits (350), Expect = 2e-35,
Identities = 129/483 (27%), Positives = 212/483 (44%), Gaps = 39/483 (8%)
Query  1    MAKKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPY-CFDQLRRRFGDVFSLQLAWTPVVVL  59
            MAKKTSSKGKLPPGP P P +GN+L +  Q  P+  F +L +++G + S+ L     V++
Sbjct  1    MAKKTSSKGKLPPGPFPYPIVGNMLQLGAQ--PHETFAKLSKKYGPLMSVHLGSLYTVIV  58

Query  60   NGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRR------FS  113
            +     +E ++ +G   + R              S G FL   G  WR+ R+      FS
Sbjct  59   SSPEMAKEIMLKYGTVFSGRTVAQAVHACDHDKISMG-FLP-IGAEWRDMRKICKEQMFS  116

Query  114  VSTLRN-LGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVI-ASLTCGR  171
              ++ +  GL K+ L+Q +     C      +  GR             N++ A+L   +
Sbjct  117  HQSMEDSQGLRKQKLQQLLDHAHRC------SEQGRAIDIREAAFITTLNLMSATLFSMQ  170

Query  172  RFEYDDPRFLRLLDLAQEGLKEESGF--------LREVLNAVPVDRHIPALAGKVLRFQK  223
              E+D    +   ++  EG+    G         +    +   V R      G++L   +
Sbjct  171  ATEFDSKVTMEFKEII-EGVASIVGVPNFADYFPILRPFDPQGVKRRADVYFGRLLALIE  229

Query  224  AFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSA  283
             +L          R+    A P     + FL  +     + ++    ++L  ++ DLF  
Sbjct  230  GYLND--------RIQSRKANPDAPKKDDFLETLVDILNSNDNKLKTDHLLHLMLDLFVG  281

Query  284  GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQR  343
            G  T++T + W +  ++ HPD   +V+ E+  V+G  +  +      +PY  AV+ E  R
Sbjct  282  GSETSTTEIEWIMEELVAHPDKMAKVKAELKSVMGDEKVVDESLMPRLPYLQAVVKESMR  341

Query  344  FGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQG  403
                 PL +      D  V G+ IPKGT ++ N  ++ +D  +W  P  F PE FLD + 
Sbjct  342  LHPPGPLLLPRKAESDQVVNGYLIPKGTQVLINAWAMGRDSTIWNNPDAFQPERFLDNKI  401

Query  404  HFVKPE-AFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPT-GQPRPSHHGV-FA  460
             F   +   +PF +GRR C G PLA   L     +L+ +F + +     P   H GV F 
Sbjct  402  DFKGQDYELIPFGSGRRVCPGMPLANRMLHTVTATLVHNFDWKLERPDAPLAEHQGVLFG  461

Query  461  FLV  463
            F V
Sbjct  462  FAV  464

Hit Number: 55, Accession Number: 5YLW_A
pdb|5YLW|A Chain A, Ferruginol synthase [Salvia miltiorrhiza]
Length = 495, Score = 137 bits (344), Expect = 2e-34,
Identities = 120/465 (26%), Positives = 201/465 (43%), Gaps = 35/465 (8%)
Query  10   KLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREAL  69
             LPPGP P P +GN+L +   N    F +L +R+G + S+ L     V+++     +E L
Sbjct  27   NLPPGPFPYPIVGNMLQLG-ANPHQVFAKLSKRYGPLMSIHLGSLYTVIVSSPEMAKEIL  85

Query  70   VTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRR------FSVSTLR-NLGL  122
              HG+  + R              S G FL      WR+ R+      FS  ++  + GL
Sbjct  86   HRHGQVFSGRTIAQAVHACDHDKISMG-FLP-VASEWRDMRKICKEQMFSNQSMEASQGL  143

Query  123  GKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVI-ASLTCGRRFEYDDPRFL  181
             ++ L+Q +     C      + SGR             N++ A+L   +  E+D    +
Sbjct  144  RRQKLQQLLDHVQKC------SDSGRAVDIREAAFITTLNLMSATLFSSQATEFDSKATM  197

Query  182  RLLDLAQEGLKEESGF--------LREVLNAVPVDRHIPALAGKVLRFQKAFLTQLDELL  233
               ++  EG+    G         +    +   V R      GK+L   + +   L+E L
Sbjct  198  EFKEII-EGVATIVGVPNFADYFPILRPFDPQGVKRRADVFFGKLLAKIEGY---LNERL  253

Query  234  TEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLA  293
               R   +P  P +D     + ++ +A    E      +   ++ DLF  G  T +T++ 
Sbjct  254  ESKRA--NPNAPKKDDFLEIVVDIIQAN---EFKLKTHHFTHLMLDLFVGGSDTNTTSIE  308

Query  294  WGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMT  353
            W +  ++++PD   R++ E+  V G  +  +      +PY  AVI EV R     PL + 
Sbjct  309  WAMSELVMNPDKMARLKAELKSVAGDEKIVDESAMPKLPYLQAVIKEVMRIHPPGPLLLP  368

Query  354  HMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPE-AFL  412
                 D EV G+ IPKGT ++ N  ++ +D ++W  P  F PE FLD +  F   +   L
Sbjct  369  RKAESDQEVNGYLIPKGTQILINAYAIGRDPSIWTDPETFDPERFLDNKIDFKGQDYELL  428

Query  413  PFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHG  457
            PF +GRR C G PLA   L +   +L+ +F + +       + H 
Sbjct  429  PFGSGRRVCPGMPLATRILHMATATLVHNFDWKLEDDSTAAADHA  473

Hit Number: 56, Accession Number: 6VBY_A
pdb|6VBY|A Chain A, Cinnamic acid 4-hydroxylase [Sorghum bicolor]
Length = 507, Score = 135 bits (339), Expect = 7e-34,
Identities = 120/467 (26%), Positives = 199/467 (43%), Gaps = 34/467 (7%)
Query  3    KKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGL  62
            K T  + +LPPGP   P +GN L V           L +RFGD+F L++    +VV++  
Sbjct  25   KLTGKRYRLPPGPAGAPVVGNWLQVGDDLNHRNLMSLAKRFGDIFLLRMGVRNLVVVSTP  84

Query  63   AAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGL  122
               +E L T G +   R    +  I  F  + Q +    YG  WR+ RR          +
Sbjct  85   ELAKEVLHTQGVEFGSRTRNVVFDI--FTGKGQDMVFTVYGDHWRKMRRIMTVPFFTNKV  142

Query  123  GKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVS----NVIASLTCGRRFEYD-D  177
              ++   W  EE A L         R      ++ + +     N +  +    RFE + D
Sbjct  143  VAQNRVGW--EEEARLVVEDVRKDPRAAAEGVVIRRRLQLMMYNDMFRIMFDTRFESEQD  200

Query  178  PRFLRLLDLAQEGLKEESGFLREVLNAVPVDRHIPALAGKVLRFQKAFLTQLDELLTEHR  237
            P F +L  L  E  +    F     + +PV R           F + +L +  +L T   
Sbjct  201  PLFNKLKALNAERSRLSQSFEYNYGDFIPVLRP----------FLRGYLNRCHDLKTRRM  250

Query  238  MTW-DPAQPPRDLTEAFLAEMEKA-----KGNPESSFNDENLRIVVADLFSAGMVTTSTT  291
              + D     R    A   E+  A     +   +   N +N+  +V ++  A + TT  +
Sbjct  251  KVFEDNFVQERKKVMAQTGEIRCAMDHILEAERKGEINHDNVLYIVENINVAAIETTLWS  310

Query  292  LAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLG  351
            + WG+  ++ HP +Q ++++E+D V+G        D   +PY  A++ E  R    +PL 
Sbjct  311  IEWGIAELVNHPAIQSKLREEMDSVLGAGVPVTEPDLERLPYLQAIVKETLRLRMAIPLL  370

Query  352  MTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFL------DAQGHF  405
            + HM   D ++ G+ IP  + ++ N   +  D   W +P  F PE FL      +A G+ 
Sbjct  371  VPHMNLNDGKLAGYDIPAESKILVNAWFLANDPKRWVRPDEFRPERFLEEEKTVEAHGND  430

Query  406  VKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPR  452
             +   F+PF  GRR+C G  LA   + +    L+Q+F    P GQ +
Sbjct  431  FR---FVPFGVGRRSCPGIILALPIIGITLGRLVQNFQLLPPPGQDK  474

Hit Number: 57, Accession Number: 8E83_A
pdb|8E83|A Chain A, Isoflavone synthase 1 [Medicago truncatula]
Length = 503, Score = 134 bits (337), Expect = 1e-33,
Identities = 137/525 (26%), Positives = 231/525 (44%), Gaps = 68/525 (13%)
Query  1    MAKKTSSKGKLPPGPLP-LPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVL  59
            MAKKTSSKGKLPP P P LP +G+L  +D     +   +L +R+G +++L     P VV 
Sbjct  1    MAKKTSSKGKLPPSPKPRLPFIGHLHLLDNPLLHHTLIKLGKRYGPLYTLYFGSMPTVVA  60

Query  60   NGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRN  119
            +     +  L TH E T+       + I         V +  + P W+  R+  ++ L N
Sbjct  61   STPDLFKLFLQTH-EATSFNTRFQTSAISRLT-YDNSVAMVPFAPYWKFIRKLIMNDLLN  118

Query  120  LGLGKKSLEQWVTEEAACLCAAFAN--HSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDD  177
                 K L    + E   +    AN   + +P      L K  ++ I+++  G   E ++
Sbjct  119  ATTVNK-LRPLRSREILKVLKVMANSAETQQPLDVTEELLKWTNSTISTMMLG---EAEE  174

Query  178  PRFLRLLDLAQEGLKEESGFLREVLNAV---------PVDRHIPALAGKVLRFQKAFLTQ  228
             R     D+A++ LK    +   V N +           D+    +  K     +  + +
Sbjct  175  VR-----DIARDVLKIFGEY--SVTNFIWPLNKFKFGNYDKRTEEIFNKYDPIIEKVIKK  227

Query  229  LDELLTEHRMTWDPAQPPRDLTEAFLAE-MEKAKGNP-ESSFNDENLRIVVADLFSAGMV  286
              E++ + R   +  +  +++   FL   +E A+    E     E ++ +V D FSAG  
Sbjct  228  RQEIVNK-RKNGEIVEGEQNV--VFLDTLLEFAQDETMEIKITKEQIKGLVVDFFSAGTD  284

Query  287  TTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGD  346
            +T+ +  W L  +I +P V ++ ++EID V+G+ R  +  D  ++PY  A++ E  R   
Sbjct  285  STAVSTEWTLSELINNPRVLKKAREEIDSVVGKDRLVDESDVQNLPYIKAIVKEAFRLHP  344

Query  347  IVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQG---  403
             +P+ +    +++ E+ G+ +P+G  ++ N+ +V +D   W KP  F PE F++  G   
Sbjct  345  PLPV-VKRKCTQECEIDGYVVPEGALILFNVWAVGRDPKYWVKPLEFRPERFIENVGEGE  403

Query  404  ---------HFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPS  454
                     HF      LPF +GRR C G  LA   +     S++Q F   VP GQ    
Sbjct  404  AASIDLRGQHF----TLLPFGSGRRMCPGVNLATAGMATMIASIIQCFDLQVP-GQHGEI  458

Query  455  HHGVFAF--------LVSPSPYELCAVP------------RHHHH  479
             +G +A         L  P  + L  VP             HHHH
Sbjct  459  LNGDYAKVSMEERPGLTVPRAHNLMCVPLARAGVADKLLSSHHHH  503

Hit Number: 58, Accession Number: 5VCD_A
pdb|5VCD|A Chain A, Cytochrome P450 3A4 [Homo sapiens]
Length = 487, Score = 111 bits (278), Expect = 9e-26,
Identities = 118/502 (24%), Positives = 193/502 (38%), Gaps = 68/502 (14%)
Query  13   PGPLPLPGLGNLLHVDFQNTPYCFD-QLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVT  71
            PGP PLP LGN+L   +      FD ++ +++G V+       PV+ +     ++  LV 
Sbjct  19   PGPTPLPFLGNIL--SYHKGFAMFDMEMHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVK  76

Query  72   HGED--TADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQ  129
                  T  RP  P+      G     + +A     W+  R     T  +  L  K +  
Sbjct  77   EAYSVFTNRRPFGPV------GFMKSAISIAE-DEEWKRLRSLLSPTFTSGKL--KEMVP  127

Query  130  WVTEEAACLCAAFANH--SGRPFRPNGLLDKAVSNVIASLTCG-----------------  170
             + +    L         +G+P     +      +VI S + G                 
Sbjct  128  IIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENT  187

Query  171  ---RRFEYDDPRFLRLLDLAQEGLKEESGFL---REVLNAVPVDRHIPALAGKVLRFQKA  224
                RF++ DP FL +             FL    EVLN     R +     K ++  K 
Sbjct  188  KKLLRFDFLDPFFLSITVFP---------FLIPILEVLNITVFPREVTNFLRKSVKRMKE  238

Query  225  FLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAG  284
              ++L++   +HR+         D  +  +      +     + +D  L         AG
Sbjct  239  --SRLEDT-QKHRV---------DFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAG  286

Query  285  MVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRF  344
              TTS+ L++ +  +  HPDVQ+++Q+EID V+     P       M Y   V++E  R 
Sbjct  287  YETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRL  346

Query  345  GDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGH  404
              I  + +  +  +D+E+ G  IPKG  ++    ++ +D   W +P +F PE F      
Sbjct  347  FPIA-MRLERVAKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKD  405

Query  405  FVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVS  464
             + P  + PF +G R C+G   A M + L    +LQ+FSF        P    +   L  
Sbjct  406  NIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPSKETQIPLKLSLGGLLQP  465

Query  465  PSPYELCAVPR-------HHHH  479
              P  L    R       HHHH
Sbjct  466  EKPVVLKVESRDGTVSGAHHHH  487

Hit Number: 59, Accession Number: 4D6Z_A
pdb|4D6Z|A Chain A, CYTOCHROME P450 3A4 [Homo sapiens]
Length = 487, Score = 110 bits (275), Expect = 2e-25,
Identities = 120/503 (24%), Positives = 196/503 (39%), Gaps = 70/503 (14%)
Query  13   PGPLPLPGLGNLLHVDFQNTPYC-FD-QLRRRFGDVFSLQLAWTPVVVLNGLAAVREALV  70
            PGP PLP LGN+L     +  +C FD +  +++G V+       PV+ +     ++  LV
Sbjct  19   PGPTPLPFLGNILSY---HKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLV  75

Query  71   --THGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLE  128
               +   T  RP  P+      G     + +A     W+  R     T  +  L  K + 
Sbjct  76   KECYSVFTNRRPFGPV------GFMKSAISIAE-DEEWKRLRSLLSPTFTSGKL--KEMV  126

Query  129  QWVTEEAACLCAAFANH--SGRPFRPNGLLDKAVSNVIASLTCG----------------  170
              + +    L         +G+P     +      +VI S + G                
Sbjct  127  PIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVEN  186

Query  171  ----RRFEYDDPRFLRLLDLAQEGLKEESGFL---REVLNAVPVDRHIPALAGKVLRFQK  223
                 RF++ DP FL +             FL    EVLN     R +     K ++  K
Sbjct  187  TKKLLRFDFLDPFFLSITVFP---------FLIPILEVLNICVFPREVTNFLRKSVKRMK  237

Query  224  AFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSA  283
               ++L++   +HR+         D  +  +     A+     + +D  L         A
Sbjct  238  E--SRLEDT-QKHRV---------DFLQLMIDSQNSAETASHKALSDLELVAQSIIFIFA  285

Query  284  GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQR  343
            G  TTS+ L++ +  +  HPDVQ+++Q+EID V+     P       M Y   V++E  R
Sbjct  286  GYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLR  345

Query  344  FGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQG  403
               I  + +  +  +D+E+ G  IPKG  ++    ++ +D   W +P +F PE F     
Sbjct  346  LFPIA-MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNK  404

Query  404  HFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLV  463
              + P  + PF +G R C+G   A M + L    +LQ+FSF        P    +   L 
Sbjct  405  DNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQ  464

Query  464  SPSPYELCAVPR-------HHHH  479
               P  L    R       HHHH
Sbjct  465  PEKPVVLKVESRDGTVSGAHHHH  487

Hit Number: 60, Accession Number: 9YK4_A
pdb|9YK4|A Chain A, Cytochrome P450 3A4 [Homo sapiens]
Length = 487, Score = 110 bits (275), Expect = 2e-25,
Identities = 119/503 (24%), Positives = 195/503 (39%), Gaps = 70/503 (14%)
Query  13   PGPLPLPGLGNLLHVDFQNTPYC-FD-QLRRRFGDVFSLQLAWTPVVVLNGLAAVREALV  70
            PGP PLP LGN+L     +  +C FD +  +++G V+       PV+ +     ++  LV
Sbjct  19   PGPTPLPFLGNILSY---HKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLV  75

Query  71   --THGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLE  128
               +   T  RP  P+      G     + +A     W+  R     T  +  L  K + 
Sbjct  76   KECYSVFTNRRPFGPV------GFMKSAISIAE-DEEWKRLRSLLSPTFTSGKL--KEMV  126

Query  129  QWVTEEAACLCAAFANH--SGRPFRPNGLLDKAVSNVIASLTCG----------------  170
              + +    L         +G+P     +      +VI S + G                
Sbjct  127  PIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVEN  186

Query  171  ----RRFEYDDPRFLRLLDLAQEGLKEESGFL---REVLNAVPVDRHIPALAGKVLRFQK  223
                 RF++ DP FL +             FL    EVLN     R +     K ++  K
Sbjct  187  TKKLLRFDFLDPFFLSITVFP---------FLIPILEVLNICVFPREVTNFLRKSVKRMK  237

Query  224  AFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSA  283
               ++L++   +HR+         D  +  +      +     + +D  L         A
Sbjct  238  E--SRLEDT-QKHRV---------DFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFA  285

Query  284  GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQR  343
            G  TTS+ L++ +  +  HPDVQ+++Q+EID V+     P       M Y   V++E  R
Sbjct  286  GYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLR  345

Query  344  FGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQG  403
               I  + +  +  +D+E+ G  IPKG  ++    ++ +D   W +P +F PE F     
Sbjct  346  LFPIA-MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNK  404

Query  404  HFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLV  463
              + P  + PF +G R C+G   A M + L    +LQ+FSF        P    +   L 
Sbjct  405  DNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPSKETQIPLKLSLGGLLQ  464

Query  464  SPSPYELCAVPR-------HHHH  479
               P  L    R       HHHH
Sbjct  465  PEKPVVLKVESRDGTVSGAHHHH  487

Hit Number: 61, Accession Number: 3TJS_A
pdb|3TJS|A Chain A, Cytochrome P450 3A4 [Homo sapiens]
Length = 487, Score = 109 bits (273), Expect = 4e-25,
Identities = 119/503 (24%), Positives = 195/503 (39%), Gaps = 70/503 (14%)
Query  13   PGPLPLPGLGNLLHVDFQNTPYC-FD-QLRRRFGDVFSLQLAWTPVVVLNGLAAVREALV  70
            PGP PLP LGN+L     +  +C FD +  +++G V+       PV+ +     ++  LV
Sbjct  19   PGPTPLPFLGNILSY---HKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLV  75

Query  71   --THGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLE  128
               +   T  RP  P+      G     + +A     W+  R     T  +  L  K + 
Sbjct  76   KECYSVFTNRRPFGPV------GFMKSAISIAE-DEEWKRLRSLLSPTFTSGKL--KEMV  126

Query  129  QWVTEEAACLCAAFANH--SGRPFRPNGLLDKAVSNVIASLTCG----------------  170
              + +    L         +G+P     +      +VI S + G                
Sbjct  127  PIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVEN  186

Query  171  ----RRFEYDDPRFLRLLDLAQEGLKEESGFL---REVLNAVPVDRHIPALAGKVLRFQK  223
                 RF++ DP FL +             FL    EVLN     R +     K ++  K
Sbjct  187  TKKLLRFDFLDPFFLSITVFP---------FLIPILEVLNICVFPREVTNFLRKSVKRMK  237

Query  224  AFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSA  283
               ++L++   +HR+         D  +  +      +     + +D  L         A
Sbjct  238  E--SRLEDT-QKHRV---------DFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFA  285

Query  284  GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQR  343
            G  TTS+ L++ +  +  HPDVQ+++Q+EID V+     P       M Y   V++E  R
Sbjct  286  GYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLR  345

Query  344  FGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQG  403
               I  + +  +  +D+E+ G  IPKG  ++    ++ +D   W +P +F PE F     
Sbjct  346  LFPIA-MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNK  404

Query  404  HFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLV  463
              + P  + PF +G R C+G   A M + L    +LQ+FSF        P    +   L 
Sbjct  405  DNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQ  464

Query  464  SPSPYELCAVPR-------HHHH  479
               P  L    R       HHHH
Sbjct  465  PEKPVVLKVESRDGTVSGAHHHH  487

Hit Number: 62, Accession Number: 7LXL_A
pdb|7LXL|A Chain A, Cytochrome P450 3A4 [Homo sapiens]
Length = 486, Score = 109 bits (273), Expect = 4e-25,
Identities = 119/503 (24%), Positives = 195/503 (39%), Gaps = 70/503 (14%)
Query  13   PGPLPLPGLGNLLHVDFQNTPYC-FD-QLRRRFGDVFSLQLAWTPVVVLNGLAAVREALV  70
            PGP PLP LGN+L     +  +C FD +  +++G V+       PV+ +     ++  LV
Sbjct  18   PGPTPLPFLGNILSY---HKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLV  74

Query  71   --THGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLE  128
               +   T  RP  P+      G     + +A     W+  R     T  +  L  K + 
Sbjct  75   KECYSVFTNRRPFGPV------GFMKSAISIAE-DEEWKRLRSLLSPTFTSGKL--KEMV  125

Query  129  QWVTEEAACLCAAFANH--SGRPFRPNGLLDKAVSNVIASLTCG----------------  170
              + +    L         +G+P     +      +VI S + G                
Sbjct  126  PIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVEN  185

Query  171  ----RRFEYDDPRFLRLLDLAQEGLKEESGFL---REVLNAVPVDRHIPALAGKVLRFQK  223
                 RF++ DP FL +             FL    EVLN     R +     K ++  K
Sbjct  186  TKKLLRFDFLDPFFLSITVFP---------FLIPILEVLNICVFPREVTNFLRKSVKRMK  236

Query  224  AFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSA  283
               ++L++   +HR+         D  +  +      +     + +D  L         A
Sbjct  237  E--SRLEDT-QKHRV---------DFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFA  284

Query  284  GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQR  343
            G  TTS+ L++ +  +  HPDVQ+++Q+EID V+     P       M Y   V++E  R
Sbjct  285  GYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLR  344

Query  344  FGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQG  403
               I  + +  +  +D+E+ G  IPKG  ++    ++ +D   W +P +F PE F     
Sbjct  345  LFPIA-MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNK  403

Query  404  HFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLV  463
              + P  + PF +G R C+G   A M + L    +LQ+FSF        P    +   L 
Sbjct  404  DNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQ  463

Query  464  SPSPYELCAVPR-------HHHH  479
               P  L    R       HHHH
Sbjct  464  PEKPVVLKVESRDGTVSGAHHHH  486

Hit Number: 63, Accession Number: 1TQN_A
pdb|1TQN|A Chain A, cytochrome P450 3A4 [Homo sapiens]
Length = 486, Score = 109 bits (272), Expect = 5e-25,
Identities = 119/503 (24%), Positives = 195/503 (39%), Gaps = 70/503 (14%)
Query  13   PGPLPLPGLGNLLHVDFQNTPYC-FD-QLRRRFGDVFSLQLAWTPVVVLNGLAAVREALV  70
            PGP PLP LGN+L     +  +C FD +  +++G V+       PV+ +     ++  LV
Sbjct  18   PGPTPLPFLGNILSY---HKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLV  74

Query  71   --THGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLE  128
               +   T  RP  P+      G     + +A     W+  R     T  +  L  K + 
Sbjct  75   KECYSVFTNRRPFGPV------GFMKSAISIAE-DEEWKRLRSLLSPTFTSGKL--KEMV  125

Query  129  QWVTEEAACLCAAFANH--SGRPFRPNGLLDKAVSNVIASLTCG----------------  170
              + +    L         +G+P     +      +VI S + G                
Sbjct  126  PIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVEN  185

Query  171  ----RRFEYDDPRFLRLLDLAQEGLKEESGFL---REVLNAVPVDRHIPALAGKVLRFQK  223
                 RF++ DP FL +             FL    EVLN     R +     K ++  K
Sbjct  186  TKKLLRFDFLDPFFLSITVFP---------FLIPILEVLNICVFPREVTNFLRKSVKRMK  236

Query  224  AFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSA  283
               ++L++   +HR+         D  +  +      +     + +D  L         A
Sbjct  237  E--SRLEDT-QKHRV---------DFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFA  284

Query  284  GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQR  343
            G  TTS+ L++ +  +  HPDVQ+++Q+EID V+     P       M Y   V++E  R
Sbjct  285  GYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLR  344

Query  344  FGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQG  403
               I  + +  +  +D+E+ G  IPKG  ++    ++ +D   W +P +F PE F     
Sbjct  345  LFPIA-MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNK  403

Query  404  HFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLV  463
              + P  + PF +G R C+G   A M + L    +LQ+FSF        P    +   L 
Sbjct  404  DNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQ  463

Query  464  SPSPYELCAVPR-------HHHH  479
               P  L    R       HHHH
Sbjct  464  PEKPVVLKVESRDGTVSGAHHHH  486

Hit Number: 64, Accession Number: 7KVK_A
pdb|7KVK|A Chain A, Cytochrome P450 3A4 [Homo sapiens]
Length = 487, Score = 109 bits (272), Expect = 5e-25,
Identities = 119/503 (24%), Positives = 195/503 (39%), Gaps = 70/503 (14%)
Query  13   PGPLPLPGLGNLLHVDFQNTPYC-FD-QLRRRFGDVFSLQLAWTPVVVLNGLAAVREALV  70
            PGP PLP LGN+L     +  +C FD +  +++G V+       PV+ +     ++  LV
Sbjct  19   PGPTPLPFLGNILSY---HKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLV  75

Query  71   --THGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLE  128
               +   T  RP  P+      G     + +A     W+  R     T  +  L  K + 
Sbjct  76   KECYSVFTNRRPFGPV------GFMKSAISIAE-DEEWKRLRSLLSPTFTSGKL--KEMV  126

Query  129  QWVTEEAACLCAAFANH--SGRPFRPNGLLDKAVSNVIASLTCG----------------  170
              + +    L         +G+P     +      +VI S + G                
Sbjct  127  PIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVEN  186

Query  171  ----RRFEYDDPRFLRLLDLAQEGLKEESGFL---REVLNAVPVDRHIPALAGKVLRFQK  223
                 RF++ DP FL +             FL    EVLN     R +     K ++  K
Sbjct  187  TKKLLRFDFLDPFFLSITVFP---------FLIPILEVLNICVFPREVTNFLRKSVKRMK  237

Query  224  AFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSA  283
               ++L++   +HR+         D  +  +      +     + +D  L         A
Sbjct  238  E--SRLEDT-QKHRV---------DFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFA  285

Query  284  GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQR  343
            G  TTS+ L++ +  +  HPDVQ+++Q+EID V+     P       M Y   V++E  R
Sbjct  286  GYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLR  345

Query  344  FGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQG  403
               I  + +  +  +D+E+ G  IPKG  ++    ++ +D   W +P +F PE F     
Sbjct  346  LFPIA-MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSAKNA  404

Query  404  HFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLV  463
              + P  + PF +G R C+G   A M + L    +LQ+FSF        P    +   L 
Sbjct  405  DNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQ  464

Query  464  SPSPYELCAVPR-------HHHH  479
               P  L    R       HHHH
Sbjct  465  PEKPVVLKVESRDGTVSGAHHHH  487

Hit Number: 65, Accession Number: 1W0E_A
pdb|1W0E|A Chain A, CYTOCHROME P450 3A4 [Homo sapiens]
Length = 485, Score = 109 bits (272), Expect = 5e-25,
Identities = 124/519 (24%), Positives = 200/519 (39%), Gaps = 74/519 (14%)
Query  1    MAKKTSSKGKLP----PGPLPLPGLGNLLHVDFQNTPYC-FD-QLRRRFGDVFSLQLAWT  54
            MA  T S G       PGP PLP LGN+L     +  +C FD +  +++G V+       
Sbjct  1    MAYGTHSHGLFKKLGIPGPTPLPFLGNILSY---HKGFCMFDMECHKKYGKVWGFYDGQQ  57

Query  55   PVVVLNGLAAVREALV--THGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRF  112
            PV+ +     ++  LV   +   T  RP  P+      G     + +A     W+  R  
Sbjct  58   PVLAITDPDMIKTVLVKECYSVFTNRRPFGPV------GFMKSAISIAE-DEEWKRLRSL  110

Query  113  SVSTLRNLGLGKKSLEQWVTEEAACLCAAFANH--SGRPFRPNGLLDKAVSNVIASLTCG  170
               T  +  L  K +   + +    L         +G+P     +      +VI S + G
Sbjct  111  LSPTFTSGKL--KEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFG  168

Query  171  --------------------RRFEYDDPRFLRLLDLAQEGLKEESGFL---REVLNAVPV  207
                                 RF++ DP FL +             FL    EVLN    
Sbjct  169  VNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFP---------FLIPILEVLNICVF  219

Query  208  DRHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESS  267
             R +     K ++  K   ++L++   +HR+         D  +  +      +     +
Sbjct  220  PREVTNFLRKSVKRMKE--SRLEDT-QKHRV---------DFLQLMIDSQNSKETESHKA  267

Query  268  FNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGD  327
             +D  L         AG  TTS+ L++ +  +  HPDVQ+++Q+EID V+     P    
Sbjct  268  LSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDT  327

Query  328  QAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW  387
               M Y   V++E  R   I  + +  +  +D+E+ G  IPKG  ++    ++ +D   W
Sbjct  328  VLQMEYLDMVVNETLRLFPIA-MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYW  386

Query  388  EKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVP  447
             +P +F PE F       + P  + PF +G R C+G   A M + L    +LQ+FSF   
Sbjct  387  TEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPC  446

Query  448  TGQPRPSHHGVFAFLVSPSPYELCAVPR-------HHHH  479
                 P    +   L    P  L    R       HHHH
Sbjct  447  KETQIPLKLSLGGLLQPEKPVVLKVESRDGTVSGAHHHH  485

Hit Number: 66, Accession Number: 6MA7_A
pdb|6MA7|A Chain A, Cytochrome P450 3A4 [Homo sapiens]
Length = 487, Score = 109 bits (272), Expect = 5e-25,
Identities = 116/500 (23%), Positives = 192/500 (38%), Gaps = 64/500 (13%)
Query  13   PGPLPLPGLGNLLHVDFQNTPYC-FD-QLRRRFGDVFSLQLAWTPVVVLNGLAAVREALV  70
            PGP PLP LGN+L     +  +C FD +  +++G V+       PV+ +     ++  LV
Sbjct  19   PGPTPLPFLGNILSY---HKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLV  75

Query  71   --THGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLE  128
               +   T  RP  P+      G     + +A     W+  R     T  +  L  K + 
Sbjct  76   KECYSVFTNRRPFGPV------GFMKSAISIAE-DEEWKRLRSLLSPTFTSGKL--KEMV  126

Query  129  QWVTEEAACLCAAFANH--SGRPFRPNGLLDKAVSNVIASLTCG----------------  170
              + +    L         +G+P     +      +VI S + G                
Sbjct  127  PIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVEN  186

Query  171  ----RRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVDRHIPALAGKVLRFQKAFL  226
                 RF++ DP FL +             FL  +L  +    +I     +V  F +  +
Sbjct  187  TKKLLRFDFLDPFFLSITVFP---------FLIPILEVL----NICVFPREVTNFLRKSV  233

Query  227  TQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMV  286
             ++ E   E     D  +   D  +  +      +     + +D  L         AG  
Sbjct  234  KRMKESRLE-----DTQKHRTDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYE  288

Query  287  TTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGD  346
            TTS+ L++ +  +  HPDVQ+++Q+EID V+     P       M Y   V++E  R   
Sbjct  289  TTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFP  348

Query  347  IVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFV  406
            I  + +  +  +D+E+ G  IPKG  ++    ++ +D   W +P +F PE F       +
Sbjct  349  IA-MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNI  407

Query  407  KPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPS  466
             P  + PF +G R C+G   A M + L    +LQ+FSF        P    +   L    
Sbjct  408  DPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEK  467

Query  467  PYELCAVPR-------HHHH  479
            P  L    R       HHHH
Sbjct  468  PVVLKVESRDGTVSGAHHHH  487

Hit Number: 67, Accession Number: 4NY4_A
pdb|4NY4|A Chain A, Cytochrome P450 3A4 [Homo sapiens]
Length = 484, Score = 109 bits (272), Expect = 5e-25,
Identities = 119/503 (24%), Positives = 195/503 (39%), Gaps = 70/503 (14%)
Query  13   PGPLPLPGLGNLLHVDFQNTPYC-FD-QLRRRFGDVFSLQLAWTPVVVLNGLAAVREALV  70
            PGP PLP LGN+L     +  +C FD +  +++G V+       PV+ +     ++  LV
Sbjct  16   PGPTPLPFLGNILSY---HKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLV  72

Query  71   --THGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLE  128
               +   T  RP  P+      G     + +A     W+  R     T  +  L  K + 
Sbjct  73   KECYSVFTNRRPFGPV------GFMKSAISIAE-DEEWKRLRSLLSPTFTSGKL--KEMV  123

Query  129  QWVTEEAACLCAAFANH--SGRPFRPNGLLDKAVSNVIASLTCG----------------  170
              + +    L         +G+P     +      +VI S + G                
Sbjct  124  PIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVEN  183

Query  171  ----RRFEYDDPRFLRLLDLAQEGLKEESGFL---REVLNAVPVDRHIPALAGKVLRFQK  223
                 RF++ DP FL +             FL    EVLN     R +     K ++  K
Sbjct  184  TKKLLRFDFLDPFFLSITVFP---------FLIPILEVLNICVFPREVTNFLRKSVKRMK  234

Query  224  AFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSA  283
               ++L++   +HR+         D  +  +      +     + +D  L         A
Sbjct  235  E--SRLEDT-QKHRV---------DFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFA  282

Query  284  GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQR  343
            G  TTS+ L++ +  +  HPDVQ+++Q+EID V+     P       M Y   V++E  R
Sbjct  283  GYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLR  342

Query  344  FGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQG  403
               I  + +  +  +D+E+ G  IPKG  ++    ++ +D   W +P +F PE F     
Sbjct  343  LFPIA-MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNK  401

Query  404  HFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLV  463
              + P  + PF +G R C+G   A M + L    +LQ+FSF        P    +   L 
Sbjct  402  DNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQ  461

Query  464  SPSPYELCAVPR-------HHHH  479
               P  L    R       HHHH
Sbjct  462  PEKPVVLKVESRDGTVSGAHHHH  484

Hit Number: 68, Accession Number: 8GK3_A
pdb|8GK3|A Chain A, Cytochrome P450 3A7 [Homo sapiens]
Length = 486, Score = 108 bits (271), Expect = 7e-25,
Identities = 117/494 (24%), Positives = 199/494 (40%), Gaps = 52/494 (11%)
Query  13   PGPLPLPGLGNLLHVDFQNTPYCFD-QLRRRFGDVFSLQLAWTPVVVLNGLAAVREALV-  70
            PGP PLP LGN L   F+   + FD +  +++G V+ +     P++ +     ++  LV 
Sbjct  18   PGPTPLPFLGNAL--SFRKGYWTFDMECYKKYGKVWGIYDGQQPMLAITDPDMIKTVLVK  75

Query  71   -THGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQ  129
              +   T  RP  P+      G     + +A     W+  R     T  +  L  K +  
Sbjct  76   ECYSVFTNRRPFGPV------GFMKNAISIAE-DEEWKRIRSLLSPTFTSGKL--KEMVP  126

Query  130  WVTEEAACLCAAFANH--SGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLA  187
             + +    L         +G+P     +      +VI S + G   +         L+  
Sbjct  127  IIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDS--------LNNP  178

Query  188  QEGLKEESGFLREVLNAVPVDRHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPR  247
            Q+   E +   +++L   P+D  +  L+ KV  F    L  L+  +    +     +  +
Sbjct  179  QDPFVENT---KKLLRFNPLDPFV--LSIKVFPFLTPILEALNITVFPREVISFLTKSVK  233

Query  248  DLTEAFLAEMEKAKGN------PESSFNDENLRIVVADL---------FSAGMVTTSTTL  292
             + E  L E +K + +         +  D      ++DL           AG  TTS+ L
Sbjct  234  QIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVL  293

Query  293  AWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGM  352
            ++ +  +  HPDVQ++VQ+EID V+     P       + Y   V++E  R    V + +
Sbjct  294  SFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFP-VAMRL  352

Query  353  THMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFL  412
              +  +D+E+ G  IPKG  ++     +  D   W +P +F PE F  A    + P  + 
Sbjct  353  ERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSAANADNIDPYIYT  412

Query  413  PFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCA  472
            PF +G R C+G   A + + L    +LQ+FSF        P        L++  P  L A
Sbjct  413  PFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLTEKPIVLKA  472

Query  473  VPR-------HHHH  479
              R       HHHH
Sbjct  473  ESRDETVSGAHHHH  486

Hit Number: 69, Accession Number: 7MK8_A
pdb|7MK8|A Chain A, Isoform 2 of Cytochrome P450 3A7 [Homo sapiens]
Length = 519, Score = 105 bits (263), Expect = 1e-23,
Identities = 107/453 (24%), Positives = 187/453 (41%), Gaps = 45/453 (10%)
Query  13   PGPLPLPGLGNLLHVDFQNTPYCFD-QLRRRFGDVFSLQLAWTPVVVLNGLAAVREALV-  70
            PGP PLP LGN L   F+   + FD +  +++G V+ +     P++ +     ++  LV 
Sbjct  19   PGPTPLPFLGNAL--SFRKGYWTFDMECYKKYGKVWGIYDGQQPMLAITDPDMIKTVLVK  76

Query  71   -THGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQ  129
              +   T  RP  P+      G     + +A     W+  R     T  +  L  K +  
Sbjct  77   ECYSVFTNRRPFGPV------GFMKNAISIAE-DEEWKRIRSLLSPTFTSGKL--KEMVP  127

Query  130  WVTEEAACLCAAFANH--SGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLA  187
             + +    L         +G+P     +      +VI S + G   +         L+  
Sbjct  128  IIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDS--------LNNP  179

Query  188  QEGLKEESGFLREVLNAVPVDRHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPR  247
            Q+   E +   +++L   P+D  +  L+ KV  F    L  L+  +    +     +  +
Sbjct  180  QDPFVENT---KKLLRFNPLDPFV--LSIKVFPFLTPILEALNITVFPREVISFLTKSVK  234

Query  248  DLTEAFLAEMEKAKGN------PESSFNDENLRIVVADL---------FSAGMVTTSTTL  292
             + E  L E +K + +         +  D      ++DL           AG  TTS+ L
Sbjct  235  QIKEGRLKETQKHRVDFLQLMIDSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVL  294

Query  293  AWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGM  352
            ++ +  +  HPDVQ++VQ+EID V+     P       + Y   V++E  R    V + +
Sbjct  295  SFIIYELATHPDVQQKVQKEIDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFP-VAMRL  353

Query  353  THMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFL  412
              +  +D+E+ G  IPKG  ++     +  D   W +P +F PE F  A    + P  + 
Sbjct  354  ERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSAANADNIDPYIYT  413

Query  413  PFSAGRRACLGEPLARMELFLFFTSLLQHFSFS  445
            PF +G R C+G   A + + L    +LQ+FSF 
Sbjct  414  PFGSGPRNCIGMRFALVNMKLALVRVLQNFSFK  446

Hit Number: 70, Accession Number: 5VEU_A
pdb|5VEU|A Chain A, Cytochrome P450 3A5 [Homo sapiens]
Length = 480, Score = 103 bits (258), Expect = 3e-23,
Identities = 118/498 (24%), Positives = 188/498 (38%), Gaps = 66/498 (13%)
Query  13   PGPLPLPGLGNLLHVDFQNTPYCFD-QLRRRFGDVFSLQLAWTPVVVLNGLAAVREALV-  70
            PGP PLP LGN+L   ++   + FD +  +++G ++       PV+ +     +R  LV 
Sbjct  18   PGPTPLPLLGNVL--SYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVK  75

Query  71   -THGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQ  129
              +   T  R   P+      G     + LA     W+  R     T  +  L  K +  
Sbjct  76   ECYSVFTNRRSLGPV------GFMKSAISLAE-DEEWKRIRSLLSPTFTSGKL--KEMFP  126

Query  130  WVTEEAACLCAAFANHS--GRPFRPNGLLDKAVSNVIASLTCG-----------------  170
             + +    L       +  G+P     +      +VI   + G                 
Sbjct  127  IIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVEST  186

Query  171  ---RRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVD----RHIPALAGKVLRFQK  223
                +F + DP FL ++            FL  V  A+ V       I  L+  V R +K
Sbjct  187  KKFLKFGFLDPLFLSIILFP---------FLTPVFEALNVSLFPKDTINFLSKSVNRMKK  237

Query  224  AFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSA  283
            + L    +    HR+         D  +  +      +     + +D  L         A
Sbjct  238  SRLNDKQK----HRL---------DFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFA  284

Query  284  GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQR  343
            G  TTS+ L++ L  +  HPDVQ+++Q+EID V+     P       M Y   V++E  R
Sbjct  285  GYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLR  344

Query  344  FGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQG  403
                V + +     +D+E+ G  IPKG+ ++    ++  D   W +P  F PE F   + 
Sbjct  345  LFP-VAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKD  403

Query  404  HFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLV  463
              + P  + PF  G R C+G   A M + L    +LQ+FSF        P        L 
Sbjct  404  S-IDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQ  462

Query  464  SPSPYELCAVPR--HHHH  479
               P  L    R  HHHH
Sbjct  463  PEKPIVLKVDSRDGHHHH  480

Hit Number: 71, Accession Number: 7LAD_A
pdb|7LAD|A Chain A, Cytochrome P450 3A5 [Homo sapiens]
Length = 481, Score = 103 bits (257), Expect = 4e-23,
Identities = 118/498 (24%), Positives = 188/498 (38%), Gaps = 66/498 (13%)
Query  13   PGPLPLPGLGNLLHVDFQNTPYCFD-QLRRRFGDVFSLQLAWTPVVVLNGLAAVREALV-  70
            PGP PLP LGN+L   ++   + FD +  +++G ++       PV+ +     +R  LV 
Sbjct  19   PGPTPLPLLGNVL--SYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVK  76

Query  71   -THGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQ  129
              +   T  R   P+      G     + LA     W+  R     T  +  L  K +  
Sbjct  77   ECYSVFTNRRSLGPV------GFMKSAISLAE-DEEWKRIRSLLSPTFTSGKL--KEMFP  127

Query  130  WVTEEAACLCAAFANHS--GRPFRPNGLLDKAVSNVIASLTCG-----------------  170
             + +    L       +  G+P     +      +VI   + G                 
Sbjct  128  IIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVEST  187

Query  171  ---RRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVD----RHIPALAGKVLRFQK  223
                +F + DP FL ++            FL  V  A+ V       I  L+  V R +K
Sbjct  188  KKFLKFGFLDPLFLSIILFP---------FLTPVFEALNVSLFPKDTINFLSKSVNRMKK  238

Query  224  AFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSA  283
            + L    +    HR+         D  +  +      +     + +D  L         A
Sbjct  239  SRLNDKQK----HRL---------DFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFA  285

Query  284  GMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQR  343
            G  TTS+ L++ L  +  HPDVQ+++Q+EID V+     P       M Y   V++E  R
Sbjct  286  GYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLR  345

Query  344  FGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQG  403
                V + +     +D+E+ G  IPKG+ ++    ++  D   W +P  F PE F   + 
Sbjct  346  LFP-VAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKD  404

Query  404  HFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLV  463
              + P  + PF  G R C+G   A M + L    +LQ+FSF        P        L 
Sbjct  405  S-IDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQ  463

Query  464  SPSPYELCAVPR--HHHH  479
               P  L    R  HHHH
Sbjct  464  PEKPIVLKVDSRDGHHHH  481

Hit Number: 72, Accession Number: 2VE3_A
pdb|2VE3|A Chain A, PUTATIVE CYTOCHROME P450 120 [Synechocystis sp. PCC 6803]
Length = 444, Score = 96.7 bits (239), Expect = 6e-21,
Identities = 120/470 (26%), Positives = 201/470 (43%), Gaps = 65/470 (14%)
Query  11   LPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALV  70
            +PPG   LP LG  L  +F N      + +++FG +F  +L    V+ ++G  A R  L 
Sbjct  13   IPPGDFGLPWLGETL--NFLNDGDFGKKRQQQFGPIFKTRLFGKNVIFISGALANR-FLF  69

Query  71   THGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRR-----FSVSTLRNL-----  120
            T  ++T  +   P++  +  GP +      + G   R +R+     F   TL +      
Sbjct  70   TKEQETF-QATWPLSTRILLGPNA---LATQMGEIHRSRRKILYQAFLPRTLDSYLPKMD  125

Query  121  GLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRF  180
            G+ +  LEQW                         L +   +V A+L  G +    +P+ 
Sbjct  126  GIVQGYLEQWGKANEVIWYPQ--------------LRRMTFDVAATLFMGEKVS-QNPQL  170

Query  181  LRLLDLAQEGLKEESGFLREVLNAVPVDRHIP-ALAGKVLRFQKAFLTQLDELLTEHRMT  239
                +   +GL            ++P+   +P  L GK  R +   L +L++++   +  
Sbjct  171  FPWFETYIQGL-----------FSLPIP--LPNTLFGKSQRARALLLAELEKIIKARQQ-  216

Query  240  WDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLM  299
                QPP +  E  L  +  A+ +     +   L+  +  L  AG  T ++ L+   LL+
Sbjct  217  ----QPPSE--EDALGILLAARDDNNQPLSLPELKDQILLLLFAGHETLTSALSSFCLLL  270

Query  300  ILHPDVQRRVQQEIDDVIGQVRRPEMGDQ-AHMPYTTAVIHEVQRFGDIVPLGMTHMTSR  358
              H D++ RV+QE + +  Q+ +    +    MPY   V+ EV R    V  G   +  +
Sbjct  271  GQHSDIRERVRQEQNKL--QLSQELTAETLKKMPYLDQVLQEVLRLIPPVGGGFRELI-Q  327

Query  359  DIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFL-DAQGHFVKPEAFLPFSAG  417
            D + QGF  PKG  +   +S    D  ++  P +F PE F  D       P A +PF  G
Sbjct  328  DCQFQGFHFPKGWLVSYQISQTHADPDLYPDPEKFDPERFTPDGSATHNPPFAHVPFGGG  387

Query  418  RRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSP  467
             R CLG+  AR+E+ LF T L+Q F +++  GQ           +V+PSP
Sbjct  388  LRECLGKEFARLEMKLFATRLIQQFDWTLLPGQ-------NLELVVTPSP  430

Hit Number: 73, Accession Number: 6C93_A
pdb|6C93|A Chain A, Cytochrome P450 4B1 [Oryctolagus cuniculus]
Length = 497, Score = 92.4 bits (228), Expect = 2e-19,
Identities = 57/194 (29%), Positives = 92/194 (47%), Gaps = 0/194 (0%)
Query  253  FLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQE  312
            FL  +   +G      +D +LR  V     AG  TT++ ++W L  M L+P+ Q+R ++E
Sbjct  263  FLDILLDVRGESGVQLSDTDLRAEVDTFMFAGHDTTTSGISWFLYCMALYPEHQQRCREE  322

Query  313  IDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRDIEVQGFRIPKGTT  372
            + +++G     +  D A M Y T  + E  R    VP     ++     V G  +P G+ 
Sbjct  323  VREILGDQDSFQWEDLAKMTYLTMCMKECFRLYPPVPQVYRQLSKPVSFVDGRSLPAGSL  382

Query  373  LITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELF  432
            +  ++ ++ ++  VW  P  F P  F         P AF+PFSAG R C+G+  A  E+ 
Sbjct  383  ISLHIYALHRNSDVWPDPEVFDPLRFSPENSSGRHPYAFIPFSAGPRNCIGQQFAMNEMK  442

Query  433  LFFTSLLQHFSFSV  446
            +     L  F FSV
Sbjct  443  VVTALCLLRFEFSV  456

Hit Number: 74, Accession Number: 7WZL_A
pdb|7WZL|A Chain A, Putative cytochrome P450 [Streptomyces avermitilis]
Length = 492, Score = 91.3 bits (225), Expect = 5e-19,
Identities = 97/348 (28%), Positives = 138/348 (40%), Gaps = 12/348 (3%)
Query  131  VTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEG  190
            V +EAA L  A+    G      G + +    V+  +  G   E       R L L QE 
Sbjct  141  VADEAAGLAEAWRGIPGGGVELVGEMHRFALRVVGRILFGTDMETTFEVIERTLPLLQEY  200

Query  191  LKEESGFLREVLNAVPVDRHIPALAGK-VLRFQKAFLTQLDELLTEHRMTWDPAQPPRDL  249
                   L+  L  V   R  P  A +   R Q       D ++   R   +      + 
Sbjct  201  A------LKRGLAPVRTPRTWPTPANRRAARTQAELFALCDGIIDSRRNRKNEGDGGEES  254

Query  250  TEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRV  309
             E  +  + +A    + S +   LR  V     AG  TT+T LA+ L L+  HP+ QRRV
Sbjct  255  GEDLVTLLVRAGNAEDGSLDAAELREQVLIFLLAGHETTATALAFALHLLARHPEQQRRV  314

Query  310  QQEIDDVIGQ--VRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRDIEVQGFRI  367
            + E D V+G    R P   D   +PY T V+ E  R     P+ +      D EV G RI
Sbjct  315  RDEADRVLGGPGGRAPTAADMEALPYLTMVLKEAMRLYPSAPV-IGRRAVADAEVDGVRI  373

Query  368  PKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLA  427
            P G  L  +     +    W  P RF PE F           A+ PF  G RAC+G+ L+
Sbjct  374  PAGADLFVSPWVTHRHPDYWPDPERFDPERFTPEAEAGRPRYAWFPFGGGPRACIGQHLS  433

Query  428  RMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR  475
             +E  L    L++ F F     +  P   G+   L++  P     +PR
Sbjct  434  MLESVLGLAVLIREFEFEAVGEEEVPLGAGI--TLLAKGPARCRVIPR  479

Hit Number: 75, Accession Number: 3K9V_A
pdb|3K9V|A Chain A, 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial [Rattus norvegicus]
Length = 482, Score = 90.5 bits (223), Expect = 9e-19,
Identities = 54/187 (29%), Positives = 87/187 (47%), Gaps = 2/187 (1%)
Query  265  ESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPE  324
            +   + + L   V +L  A + TT+ +L W L  +  +P  QRR+ QE+  V+   + P 
Sbjct  276  QDHLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLQEVQSVLPDNQTPR  335

Query  325  MGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDE  384
              D  +MPY  A + E  R    VP   T    +   +  + +PKGT L  N   +   E
Sbjct  336  AEDLRNMPYLKACLKESMRLTPSVPFT-TRTLDKPTVLGEYALPKGTVLTLNTQVLGSSE  394

Query  385  AVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSF  444
              +E   +F PE +L  +   + P A LPF  G+R C+G  LA ++L L    ++Q +  
Sbjct  395  DNFEDSHKFRPERWLQKEKK-INPFAHLPFGIGKRMCIGRRLAELQLHLALCWIIQKYDI  453

Query  445  SVPTGQP  451
                 +P
Sbjct  454  VATDNEP  460

Hit Number: 76, Accession Number: 5T6Q_A
pdb|5T6Q|A Chain A, Cytochrome P450 4B1 [Oryctolagus cuniculus]
Length = 497, Score = 90.5 bits (223), Expect = 10e-19,
Identities = 56/194 (29%), Positives = 91/194 (47%), Gaps = 0/194 (0%)
Query  253  FLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQE  312
            FL  +   +G      +D +LR  V      G  TT++ ++W L  M L+P+ Q+R ++E
Sbjct  263  FLDILLDVRGESGVQLSDTDLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQQRCREE  322

Query  313  IDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRDIEVQGFRIPKGTT  372
            + +++G     +  D A M Y T  + E  R    VP     ++     V G  +P G+ 
Sbjct  323  VREILGDQDSFQWEDLAKMTYLTMCMKECFRLYPPVPQVYRQLSKPVSFVDGRSLPAGSL  382

Query  373  LITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELF  432
            +  ++ ++ ++  VW  P  F P  F         P AF+PFSAG R C+G+  A  E+ 
Sbjct  383  ISLHIYALHRNSDVWPDPEVFDPLRFSPENSSGRHPYAFIPFSAGPRNCIGQQFAMNEMK  442

Query  433  LFFTSLLQHFSFSV  446
            +     L  F FSV
Sbjct  443  VVTALCLLRFEFSV  456

Hit Number: 77, Accession Number: 7LRL_A
pdb|7LRL|A Chain A, Cholesterol 24-hydroxylase [Homo sapiens]
Length = 474, Score = 81.6 bits (200), Expect = 6e-16,
Identities = 54/189 (29%), Positives = 92/189 (49%), Gaps = 9/189 (5%)
Query  265  ESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPE  324
            E + +DE L       F AG  T++  LA+ ++ +   P++  R+Q E+D+VIG  R  +
Sbjct  264  EGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLD  323

Query  325  MGDQAHMPYTTAVIHEVQRFGDIVP--LGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLK  382
              D   + Y + V+ E  R   + P   G   +   +  + G R+P  T L+ +   + +
Sbjct  324  FEDLGRLQYLSQVLKESLR---LYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGR  380

Query  383  DEAVWEKPFRFHPEHFLDAQGHFVKPE-AFLPFSAGRRACLGEPLARMELFLFFTSLLQH  441
             +  +E P  F+P+ F        KP   + PFS G R+C+G+  A+ME+ +    LLQ 
Sbjct  381  MDTYFEDPLTFNPDRFGPGAP---KPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQR  437

Query  442  FSFSVPTGQ  450
              F +  GQ
Sbjct  438  LEFRLVPGQ  446

Hit Number: 78, Accession Number: 2Q9F_A
pdb|2Q9F|A Chain A, Cytochrome P450 46A1 [unidentified]
Length = 456, Score = 81.3 bits (199), Expect = 10e-16,
Identities = 54/189 (29%), Positives = 92/189 (49%), Gaps = 9/189 (5%)
Query  265  ESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPE  324
            E + +DE L       F AG  T++  LA+ ++ +   P++  R+Q E+D+VIG  R  +
Sbjct  236  EGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLD  295

Query  325  MGDQAHMPYTTAVIHEVQRFGDIVP--LGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLK  382
              D   + Y + V+ E  R   + P   G   +   +  + G R+P  T L+ +   + +
Sbjct  296  FEDLGRLQYLSQVLKESLR---LYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGR  352

Query  383  DEAVWEKPFRFHPEHFLDAQGHFVKPE-AFLPFSAGRRACLGEPLARMELFLFFTSLLQH  441
             +  +E P  F+P+ F        KP   + PFS G R+C+G+  A+ME+ +    LLQ 
Sbjct  353  MDTYFEDPLTFNPDRFGPGAP---KPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQR  409

Query  442  FSFSVPTGQ  450
              F +  GQ
Sbjct  410  LEFRLVPGQ  418

Hit Number: 79, Accession Number: 8X3E_A
pdb|8X3E|A Chain A, Taxadiene 5-alpha hydroxylase [Taxus cuspidata]
Length = 424, Score = 80.9 bits (198), Expect = 10e-16,
Identities = 112/438 (26%), Positives = 175/438 (40%), Gaps = 54/438 (12%)
Query  36   FDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQ  95
            FD+  ++FG VF   L   P VVL G A  R  L    +      P    +++G     +
Sbjct  7    FDERVKKFGLVFKTSLIGHPTVVLCGPAGNRLILSNEEKLVQMSWPAQFMKLMG-----E  61

Query  96   GVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWV----TEEAACLCAAFANHSGRPFR  151
                 R G    E      S L     G  +L+ ++    TE  + +   +         
Sbjct  62   NSVATRRG----EDHIVMRSALAGF-FGPGALQSYIGKMNTEIQSHINEKWKGKDEVNVL  116

Query  152  PNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVDRHI  211
            P  L+ + V N+ A L      + +  R  +LL+    G      F      A+P+D  +
Sbjct  117  P--LVRELVFNISAILFFNIYDKQEQDRLHKLLETILVG-----SF------ALPID--L  161

Query  212  P------ALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPE  265
            P      AL G+  +  K  L+ + +   +  +    A   +DL    L      KG P 
Sbjct  162  PGFGFHRALQGRA-KLNKIMLSLIKK--RKEDLQSGSATATQDLLSVLLT-FRDDKGTPL  217

Query  266  SSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPE-  324
            +  NDE L    + L  A   TT++ +A    L+  +P+  ++V QE  +++      E 
Sbjct  218  T--NDEILD-NFSSLLHASYDTTTSPMALIFKLLSSNPECYQKVVQEQLEILSNKEEGEE  274

Query  325  --MGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLK  382
                D   M YT  V  E  R    V  G       DI+  G+ IPKG  L+    S   
Sbjct  275  ITWKDLKAMKYTWQVAQETLRMFPPV-FGTFRKAITDIQYDGYTIPKGWKLLWTTYSTHP  333

Query  383  DEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF  442
             +  + +P +F P  F D +G  V P  FLPF  G+R+C+G   ++ME+ LF    ++ F
Sbjct  334  KDLYFNEPEKFMPSRF-DQEGKHVAPYTFLPFGGGQRSCVGWEFSKMEILLFVHHFVKTF  392

Query  443  SFSVP-------TGQPRP  453
            S   P       +G P P
Sbjct  393  SSYTPVDPDEKISGDPLP  410

Hit Number: 80, Accession Number: 8X1W_A
pdb|8X1W|A Chain A, Taxadiene 5-alpha hydroxylase [Taxus cuspidata]
Length = 439, Score = 80.9 bits (198), Expect = 1e-15,
Identities = 112/438 (26%), Positives = 175/438 (40%), Gaps = 54/438 (12%)
Query  36   FDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQ  95
            FD+  ++FG VF   L   P VVL G A  R  L    +      P    +++G     +
Sbjct  21   FDERVKKFGLVFKTSLIGHPTVVLCGPAGNRLILSNEEKLVQMSWPAQFMKLMG-----E  75

Query  96   GVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWV----TEEAACLCAAFANHSGRPFR  151
                 R G    E      S L     G  +L+ ++    TE  + +   +         
Sbjct  76   NSVATRRG----EDHIVMRSALAGF-FGPGALQSYIGKMNTEIQSHINEKWKGKDEVNVL  130

Query  152  PNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVDRHI  211
            P  L+ + V N+ A L      + +  R  +LL+    G      F      A+P+D  +
Sbjct  131  P--LVRELVFNISAILFFNIYDKQEQDRLHKLLETILVG-----SF------ALPID--L  175

Query  212  P------ALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPE  265
            P      AL G+  +  K  L+ + +   +  +    A   +DL    L      KG P 
Sbjct  176  PGFGFHRALQGRA-KLNKIMLSLIKK--RKEDLQSGSATATQDLLSVLLT-FRDDKGTPL  231

Query  266  SSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPE-  324
            +  NDE L    + L  A   TT++ +A    L+  +P+  ++V QE  +++      E 
Sbjct  232  T--NDEILD-NFSSLLHASYDTTTSPMALIFKLLSSNPECYQKVVQEQLEILSNKEEGEE  288

Query  325  --MGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLK  382
                D   M YT  V  E  R    V  G       DI+  G+ IPKG  L+    S   
Sbjct  289  ITWKDLKAMKYTWQVAQETLRMFPPV-FGTFRKAITDIQYDGYTIPKGWKLLWTTYSTHP  347

Query  383  DEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF  442
             +  + +P +F P  F D +G  V P  FLPF  G+R+C+G   ++ME+ LF    ++ F
Sbjct  348  KDLYFNEPEKFMPSRF-DQEGKHVAPYTFLPFGGGQRSCVGWEFSKMEILLFVHHFVKTF  406

Query  443  SFSVP-------TGQPRP  453
            S   P       +G P P
Sbjct  407  SSYTPVDPDEKISGDPLP  424

Hit Number: 81, Accession Number: 7P6L_A
pdb|7P6L|A Chain A, Bifunctional cytochrome P450/NADPH--P450 reductase [Thermothelomyces thermophilus ATCC 42464]
Length = 464, Score = 79.0 bits (193), Expect = 4e-15,
Identities = 64/208 (31%), Positives = 98/208 (47%), Gaps = 20/208 (10%)
Query  247  RDLTEAFLAEMEKAKGN--PESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPD  304
            +DL  A L  ++   G    +SS  D  +  ++A     G  TTS  L++   L+I H D
Sbjct  237  KDLLSAMLDGVDAKTGQKLSDSSIIDNLITFLIA-----GHETTSGLLSFAFYLLIKHQD  291

Query  305  VQRRVQQEIDDVIGQ--VRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRDIEV  362
              R+ Q+E+D VIG+  ++   +     +PY  AV+ E  R    +P+   +  ++  EV
Sbjct  292  AYRKAQEEVDRVIGKGPIKVEHI---KKLPYIAAVLRETLRLCPTIPI--INRAAKQDEV  346

Query  363  QG--FRIPKGTTLITNLSSVLKDEAVW-EKPFRFHPEHFLDAQGHFVK---PEAFLPFSA  416
             G  + + K   L   L+    D AV+ E   +F PE  LD     +    P+ + PF  
Sbjct  347  IGGKYAVAKDQRLALLLAQSHLDPAVYGETAKQFIPERMLDENFERLNREYPDCWKPFGT  406

Query  417  GRRACLGEPLARMELFLFFTSLLQHFSF  444
            G RAC+G P A  E  L    LLQ+F F
Sbjct  407  GMRACIGRPFAWQEAVLVMAMLLQNFDF  434

Hit Number: 82, Accession Number: 6L8H_A
pdb|6L8H|A Chain A, Carotene epsilon-monooxygenase, chloroplastic [Arabidopsis thaliana]
Length = 471, Score = 78.6 bits (192), Expect = 7e-15,
Identities = 64/236 (27%), Positives = 101/236 (43%), Gaps = 32/236 (14%)
Query  254  LAEMEKAKGNPESSFNDEN---LRIVVA------------DLFS---AGMVTTSTTLAWG  295
            + E E  + N E   ND +   LR ++A            DL S   AG  TT + L W 
Sbjct  232  IVEREGERINDEEYVNDADPSILRFLLASREEVSSVQLRDDLLSMLVAGHETTGSVLTWT  291

Query  296  LLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHM  355
            L L+  +    R+ Q+E+D V+ + R P   D   + Y T  I+E  R     P+ +   
Sbjct  292  LYLLSKNSSALRKAQEEVDRVL-EGRNPAFEDIKELKYITRCINESMRLYPHPPVLIRRA  350

Query  356  TSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPE----AF  411
               DI    +++  G  ++ ++ ++ +   VWEK   F PE F D  G           F
Sbjct  351  QVPDILPGNYKVNTGQDIMISVYNIHRSSEVWEKAEEFLPERF-DIDGAIPNETNTDFKF  409

Query  412  LPFSAGRRACLGEPLARMELFLFFTSLLQHF--------SFSVPTGQPRPSHHGVF  459
            +PFS G R C+G+  A ME  +     LQ          + S+ TG    + +G++
Sbjct  410  IPFSGGPRKCVGDQFALMEAIVALAVFLQRLNVELVPDQTISMTTGATIHTTNGLY  465

Hit Number: 83, Accession Number: 6J94_A
pdb|6J94|A Chain A, Protein LUTEIN DEFICIENT 5, chloroplastic [Arabidopsis thaliana]
Length = 519, Score = 77.4 bits (189), Expect = 2e-14,
Identities = 55/195 (28%), Positives = 93/195 (48%), Gaps = 8/195 (4%)
Query  260  AKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQ  319
            A G+  SS   + LR  +  +  AG  T++  L W   L+   P V  ++Q+E+D VIG 
Sbjct  281  ASGDDVSS---KQLRDDLMTMLIAGHETSAAVLTWTFYLLTTEPSVVAKLQEEVDSVIGD  337

Query  320  VRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSS  379
             R P + D   + YTT V++E  R     P+ +      DI +  + I +G  +  ++ +
Sbjct  338  -RFPTIQDMKKLKYTTRVMNESLRLYPQPPVLIRRSIDNDI-LGEYPIKRGEDIFISVWN  395

Query  380  VLKDEAVWEKPFRFHPEHF-LDAQGHFVKPEAF--LPFSAGRRACLGEPLARMELFLFFT  436
            + +    W+   +F+PE + LD        + F  LPF  G R C+G+  A  E  +   
Sbjct  396  LHRSPLHWDDAEKFNPERWPLDGPNPNETNQNFSYLPFGGGPRKCIGDMFASFENVVAIA  455

Query  437  SLLQHFSFSVPTGQP  451
             L++ F+F +  G P
Sbjct  456  MLIRRFNFQIAPGAP  470

Hit Number: 84, Accession Number: 6L8I_A
pdb|6L8I|A Chain A, Protein LUTEIN DEFICIENT 5, chloroplastic [Arabidopsis thaliana]
Length = 519, Score = 77.0 bits (188), Expect = 2e-14,
Identities = 55/195 (28%), Positives = 93/195 (48%), Gaps = 8/195 (4%)
Query  260  AKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQ  319
            A G+  SS   + LR  +  +  AG  T++  L W   L+   P V  ++Q+E+D VIG 
Sbjct  281  ASGDDVSS---KQLRDDLMTMLIAGHETSAAVLTWTFYLLTTEPSVVAKLQEEVDSVIGD  337

Query  320  VRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSS  379
             R P + D   + YTT V++E  R     P+ +      DI +  + I +G  +  ++ +
Sbjct  338  -RFPTIQDMKKLKYTTRVMNESLRLYPQPPVLIRRSIDNDI-LGEYPIKRGEDIFISVWN  395

Query  380  VLKDEAVWEKPFRFHPEHF-LDAQGHFVKPEAF--LPFSAGRRACLGEPLARMELFLFFT  436
            + +    W+   +F+PE + LD        + F  LPF  G R C+G+  A  E  +   
Sbjct  396  LHRSPLHWDDAEKFNPERWPLDGPNPNETNQNFSYLPFGGGPRKCIGDMFASFENVVAIA  455

Query  437  SLLQHFSFSVPTGQP  451
             L++ F+F +  G P
Sbjct  456  MLIRRFNFQIAPGAP  470

Hit Number: 85, Accession Number: 5E9Z_A
pdb|5E9Z|A Chain A, Bifunctional cytochrome P450/NADPH--P450 reductase [Priestia megaterium]
Length = 469, Score = 73.2 bits (178), Expect = 4e-13,
Identities = 60/232 (26%), Positives = 98/232 (42%), Gaps = 24/232 (10%)
Query  214  LAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENL  273
            L  K++  +KA   Q D+LLT      DP                   G P    +DEN+
Sbjct  217  LVDKIIADRKASGEQSDDLLTHMLNGKDPE-----------------TGEP---LDDENI  256

Query  274  RIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPY  333
            R  +     AG VTTS  L++ L  ++ +P V ++  +E   V+     P       + Y
Sbjct  257  RYQIITFLIAGHVTTSGLLSFALYFLVKNPYVLQKAAEEAARVLVD-PVPSYKQVKQLKY  315

Query  334  TTAVIHEVQRFGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFR  392
               V++E  R     P    +     +    + + KG  L+  +  + +D+ +W +    
Sbjct  316  VGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEE  375

Query  393  FHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSF  444
            F PE F +     +   AF PF  G+RAC+G+  A  E  L  + +L+HF F
Sbjct  376  FRPERFENPSA--IPQHAFKPFGNGQRACIGQQFALHEATLVLSMMLKHFDF  425

Hit Number: 86, Accession Number: 6IAO_A
pdb|6IAO|A Chain A, Bifunctional cytochrome P450/NADPH--P450 reductase [Priestia megaterium]
Length = 507, Score = 73.2 bits (178), Expect = 5e-13,
Identities = 60/232 (26%), Positives = 98/232 (42%), Gaps = 24/232 (10%)
Query  214  LAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENL  273
            L  K++  +KA   Q D+LLT      DP                   G P    +DEN+
Sbjct  250  LVDKIIADRKASGEQSDDLLTHMLNGKDPE-----------------TGEP---LDDENI  289

Query  274  RIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPY  333
            R  +     AG VTTS  L++ L  ++ +P V ++  +E   V+     P       + Y
Sbjct  290  RYQIITFLIAGHVTTSGLLSFALYFLVKNPYVLQKAAEEAARVLVD-PVPSYKQVKQLKY  348

Query  334  TTAVIHEVQRFGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFR  392
               V++E  R     P    +     +    + + KG  L+  +  + +D+ +W +    
Sbjct  349  VGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEE  408

Query  393  FHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSF  444
            F PE F +     +   AF PF  G+RAC+G+  A  E  L  + +L+HF F
Sbjct  409  FRPERFENPSA--IPQHAFKPFGNGQRACIGQQFALHEATLVLSMMLKHFDF  458

Hit Number: 87, Accession Number: 4ZF6_A
pdb|4ZF6|A Chain A, Bifunctional P-450/NADPH-P450 reductase [Priestia megaterium]
Length = 461, Score = 72.4 bits (176), Expect = 7e-13,
Identities = 68/296 (23%), Positives = 119/296 (40%), Gaps = 41/296 (14%)
Query  151  RPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVDRH  210
            +P+  +   V  +  ++   +R   DDP +    D  +   +E+   + ++++ +  DR 
Sbjct  170  QPHPFITSMVRALDEAMNKQQRANPDDPAY----DENKRQFQEDIKVMNDLVDKIIADR-  224

Query  211  IPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFND  270
                        KA   Q D+LLT      DP                   G P    +D
Sbjct  225  ------------KASGEQSDDLLTHMLNGKDPE-----------------TGEP---LDD  252

Query  271  ENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAH  330
            EN+R  +     AG VTTS  L++ L  ++ +P V ++  +E   V+     P       
Sbjct  253  ENIRYQIITFLIAGHVTTSGLLSFALYFLVKNPHVLQKAAEEAARVLVD-PVPSYKQVKQ  311

Query  331  MPYTTAVIHEVQRFGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EK  389
            + Y   V++E  R     P    +     +    + + KG  L+  +  + +D+ +W + 
Sbjct  312  LKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDD  371

Query  390  PFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFS  445
               F PE F +     +   AF PF  G+RAC+G+  A  E  L    +L+HF F 
Sbjct  372  VEEFRPERFENPSA--IPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFE  425

Hit Number: 88, Accession Number: 4ZF8_A
pdb|4ZF8|A Chain A, Bifunctional P-450/NADPH-P450 reductase [Priestia megaterium]
Length = 468, Score = 72.0 bits (175), Expect = 8e-13,
Identities = 68/296 (23%), Positives = 119/296 (40%), Gaps = 41/296 (14%)
Query  151  RPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVDRH  210
            +P+  +   V  +  ++   +R   DDP +    D  +   +E+   + ++++ +  DR 
Sbjct  170  QPHPFITSMVRALDEAMNKQQRANPDDPAY----DENKRQFQEDIKVMNDLVDKIIADR-  224

Query  211  IPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFND  270
                        KA   Q D+LLT      DP                   G P    +D
Sbjct  225  ------------KASGEQSDDLLTHMLNGKDPE-----------------TGEP---LDD  252

Query  271  ENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAH  330
            EN+R  +     AG VTTS  L++ L  ++ +P V ++  +E   V+     P       
Sbjct  253  ENIRYQIITFLIAGHVTTSGLLSFALYFLVKNPHVLQKAAEEAARVLVD-PVPSYKQVKQ  311

Query  331  MPYTTAVIHEVQRFGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EK  389
            + Y   V++E  R     P    +     +    + + KG  L+  +  + +D+ +W + 
Sbjct  312  LKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDD  371

Query  390  PFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFS  445
               F PE F +     +   AF PF  G+RAC+G+  A  E  L    +L+HF F 
Sbjct  372  VEEFRPERFENPSA--IPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFE  425

Hit Number: 89, Accession Number: 8HKJ_A
pdb|8HKJ|A Chain A, Bifunctional cytochrome P450/NADPH--P450 reductase [Bacillus cereus]
Length = 458, Score = 72.0 bits (175), Expect = 8e-13,
Identities = 108/460 (23%), Positives = 181/460 (39%), Gaps = 48/460 (10%)
Query  1    MAKKTSSKGKLPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLN  60
            M KK S+     P P     LGNL  +D       F ++   +G +F +Q     ++V++
Sbjct  1    MEKKVSA----IPQPKTYGPLGNLPLIDKDKPTLSFIKIAEEYGPIFQIQTLSDTIIVVS  56

Query  61   GLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLAR-YGPAWREQRRFSVSTLRN  119
            G   V E       D +      + ++  F     G+F +  + P W++     + T   
Sbjct  57   GHELVAEVCDETRFDKSIEGA--LAKVRAFA--GDGLFTSETHEPNWKKAHNILMPTFSQ  112

Query  120  LGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLT------CGRRF  173
              +  K     + + A  L   +A        PN  +D  V   +  LT      CG  F
Sbjct  113  RAM--KDYHAMMVDIAVQLVQKWAR-----LNPNENVD--VPEDMTRLTLDTIGLCG--F  161

Query  174  EYDDPRFLRLLDLAQEGLKEESGFLREVLNAVP-VDRHIPALAGKVLRFQ---KAFLTQL  229
             Y    F R  +     +   +  L E ++ +  +D     +     +FQ   ++  + +
Sbjct  162  NYRFNSFYR--ETPHPFITSMTRALDEAMHQLQRLDIEDKLMWRTKRQFQHDIQSMFSLV  219

Query  230  DELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTS  289
            D ++ E + + D  Q   DL    L   +   G      +DEN+R  +     AG  TTS
Sbjct  220  DNIIAERKSSGD--QEENDLLSRMLNVPDPETG---EKLDDENIRFQIITFLIAGHETTS  274

Query  290  TTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVP  349
              L++ +  ++ +PD  ++  +E+D V+     P       + Y   +++E  R     P
Sbjct  275  GLLSFAIYFLLKNPDKLKKAYEEVDRVLTD-PTPTYQQVMKLKYMRMILNESLRLWPTAP  333

Query  350  LGMTHMTSRDIEVQG-FRIPKGTTLITNLSSVL-KDEAVW-EKPFRFHPEHF--LDAQGH  404
               +     D  + G + I KG   I+ L   L +D+  W +    F PE F  LD   H
Sbjct  334  -AFSLYAKEDTVIGGKYPIKKGEDRISVLIPQLHRDKDAWGDNVEEFQPERFEELDKVPH  392

Query  405  FVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSF  444
                 A+ PF  G+RAC+G   A  E  L    LLQHF  
Sbjct  393  ----HAYKPFGNGQRACIGMQFALHEATLVMGMLLQHFEL  428

Hit Number: 90, Accession Number: 1ZOA_A
pdb|1ZOA|A Chain A, Bifunctional P-450:NADPH-P450 reductase [Priestia megaterium]
Length = 473, Score = 71.2 bits (173), Expect = 2e-12,
Identities = 60/233 (26%), Positives = 97/233 (42%), Gaps = 24/233 (10%)
Query  214  LAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENL  273
            L  K++  +KA   Q D+LLT      DP                   G P    +DEN+
Sbjct  218  LVDKIIADRKASGEQSDDLLTHMLNGKDPE-----------------TGEP---LDDENI  257

Query  274  RIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPY  333
            R  +     AG  TTS  L++ L  ++ +P V ++  +E   V+     P       + Y
Sbjct  258  RYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVD-PVPSYKQVKQLKY  316

Query  334  TTAVIHEVQRFGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFR  392
               V++E  R    VP    +     +    + + KG  L+  +  + +D+ +W +    
Sbjct  317  VGMVLNEALRLWPTVPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEE  376

Query  393  FHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFS  445
            F PE F +     +   AF PF  G+RAC+G+  A  E  L    +L+HF F 
Sbjct  377  FRPERFENPSA--IPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFE  427

Hit Number: 91, Accession Number: 6Q2C_A
pdb|6Q2C|A Chain A, Obtusifoliol 14alphademethylase [Acanthamoeba castellanii str. Neff]
Length = 460, Score = 70.5 bits (171), Expect = 2e-12,
Identities = 119/489 (24%), Positives = 206/489 (42%), Gaps = 68/489 (14%)
Query  1    MAKKTSSKGKLPP---GPLPLPGLGNLLHVDFQNTP--YCFDQLRRRFGDVFSLQLAWTP  55
            MAKKTSSKGKLPP     +P  G G    + F   P  Y  D  ++ +GD+F++++    
Sbjct  1    MAKKTSSKGKLPPVVSSLIPFVGSG----LSFAGGPLQYTTDAYKK-YGDIFTMKVFGQR  55

Query  56   VVVLNGLAAVREALVTHG--EDTADRP---PVPITQILGFGPRS-QGVFLARYGPAWREQ  109
            +  L G  A      + G  E + D P    VPI     FGP    G  LA       +Q
Sbjct  56   LTFLVGPDA-HVPFFSQGDAELSQDEPYQFSVPI-----FGPNVVYGADLAHRN----QQ  105

Query  110  RRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLT-  168
             +F  ++L    L  +S    + +EA    A +        R     D     +I + + 
Sbjct  106  LKFIAASLSTKAL--QSYVPLIVKEAEDFFAKWDKSGTVDIR-----DALAELIILTASR  158

Query  169  CGRRFEYDDPRFLRLLDLAQ---EGLKEESGFLREVLNAVPVDRHIPALAGKVLRFQKAF  225
            C    E  +  F  +  L Q   EGL   S F       +P+  H      ++     A 
Sbjct  159  CLMGKEIRENLFTEVAKLYQTLDEGLLPISVFF----PYLPIPAHKRRDEARL-----AM  209

Query  226  LTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGM  285
            +    +++ E R   +P     D  + F   M+      E + NDE +  ++  L  AG 
Sbjct  210  VRMFKKIIDERRA--NPEVKHNDCLQVF---MDARYRGEEQALNDEEITGLMIALLFAGQ  264

Query  286  VTTSTTLAWGLLLMILHPDVQR---RVQQEIDDVIGQVRRPEMGDQAHMPYTTAV--IHE  340
             T+S T +W  LL+    + ++    V +E +++     R E GD+  M     +  +H 
Sbjct  265  HTSSVTGSWTGLLLFEANNKKKFLPGVLEEQEEI-----RKEFGDELTMEALNKMDKLHR  319

Query  341  -VQRFGDIVP--LGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEH  397
             V+    + P  L +     +    + + +P+G T+  + +  ++ E V+    +++PE 
Sbjct  320  CVKEALRMYPPLLFVMRKVIKPFSYKDYYVPEGDTVFVSPALSMRVEEVFPNADQYNPER  379

Query  398  FLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHG  457
            F++      K   F+ F AGR  C+GE  A +++   ++ LL++F   +    P+P +  
Sbjct  380  FVEEDKQAQKYR-FVGFGAGRHGCMGENFAYLQIKTIWSVLLRNFDIELVGELPKPDYT-  437

Query  458  VFAFLVSPS  466
              A +V P+
Sbjct  438  --AMVVGPA  444

Hit Number: 92, Accession Number: 4RSN_A
pdb|4RSN|A Chain A, Bifunctional P-450/NADPH-P450 reductase [Priestia megaterium]
Length = 460, Score = 70.5 bits (171), Expect = 3e-12,
Identities = 61/237 (26%), Positives = 97/237 (41%), Gaps = 24/237 (10%)
Query  214  LAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENL  273
            L  K++  +KA   Q D+LLT      DP                   G P    +DEN+
Sbjct  220  LVDKIIADRKASGEQSDDLLTHMLNGKDPET-----------------GEP---LDDENI  259

Query  274  RIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPY  333
            R  +     AG VTTS  L++ L  ++ +P V ++  +E   V+     P       + Y
Sbjct  260  RYQIITFLIAGHVTTSGLLSFALYFLVKNPHVLQKAAEEAARVLVD-PVPSYKQVKQLKY  318

Query  334  TTAVIHEVQRFGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFR  392
               V++E  R     P    +     +    + + KG  L+  +  + +D+ +W +    
Sbjct  319  VDMVLNEALRLWPTAPAFSLYAKEDTVLGGKYPLEKGDELMVLIPQLHRDKTIWGDDVEE  378

Query  393  FHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG  449
            F PE F +     +   AF PF  G+RAC G+  A  E  L    +L+HF F   T 
Sbjct  379  FRPERFENPSA--IPQHAFKPFGNGQRACPGQQFALHEATLVLGMMLKHFDFEDHTN  433

Hit Number: 93, Accession Number: 9WMA_A
pdb|9WMA|A Chain A, Bifunctional cytochrome P450/NADPH--P450 reductase [Priestia megaterium NBRC 15308 = ATCC 14581]
Length = 455, Score = 70.1 bits (170), Expect = 3e-12,
Identities = 66/280 (24%), Positives = 113/280 (40%), Gaps = 41/280 (15%)
Query  171  RRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVDRHIPALAGKVLRFQKAFLTQLD  230
            +R   DDP +    D  +  ++E++  + ++++ +  DR             KA   Q D
Sbjct  189  QRANPDDPAY----DENKRQIQEDTKVMNDLVDKIIADR-------------KASGEQSD  231

Query  231  ELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTST  290
            +LLT      DP                   G P    +DEN+R  +     AG  TTS 
Sbjct  232  DLLTHMLNGKDPE-----------------TGEP---LDDENIRYQIITFLIAGHETTSG  271

Query  291  TLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPL  350
             L++ L  ++ +P V ++  +E   V+     P       + Y   V++E  R     P 
Sbjct  272  LLSFALYFLVKNPHVLQKAAEEAARVLVDPV-PSYKQVKQLKYVGMVLNEALRLWPTAPA  330

Query  351  GMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFRFHPEHFLDAQGHFVKPE  409
               +     +    + + KG  L+  +  + +D+ +W +    F PE F +     +   
Sbjct  331  FSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSA--IPQH  388

Query  410  AFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG  449
            AF PF  G+RAC+G+  A  E  L    +L+HF F   T 
Sbjct  389  AFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTN  428

Hit Number: 94, Accession Number: 7Y9J_A
pdb|7Y9J|A Chain A, Bifunctional cytochrome P450/NADPH--P450 reductase [Priestia megaterium NBRC 15308 = ATCC 14581]
Length = 465, Score = 69.7 bits (169), Expect = 4e-12,
Identities = 59/233 (25%), Positives = 96/233 (41%), Gaps = 24/233 (10%)
Query  214  LAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENL  273
            L  K++  +KA   Q D+LLT      DP                   G P    +DEN+
Sbjct  216  LVDKIIADRKASGEQSDDLLTHMLNGKDPET-----------------GEP---LDDENI  255

Query  274  RIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPY  333
            R  +     AG  TTS  L++ L  ++ +P V ++  +E   V+     P       + Y
Sbjct  256  RYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPV-PSYKQVKQLKY  314

Query  334  TTAVIHEVQRFGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFR  392
               V++E  R     P    +     +    + + KG  L+  +  + +D+ +W +    
Sbjct  315  VGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEE  374

Query  393  FHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFS  445
            F PE F +     +   AF PF  G+RAC+G+  A  E  L    +L+HF F 
Sbjct  375  FRPERFENPSA--IPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFE  425

Hit Number: 95, Accession Number: 4HGG_A
pdb|4HGG|A Chain A, Bifunctional P-450/NADPH-P450 reductase [Priestia megaterium]
Length = 455, Score = 69.7 bits (169), Expect = 5e-12,
Identities = 53/203 (26%), Positives = 90/203 (44%), Gaps = 7/203 (3%)
Query  250  TEAFLAEMEKAKGNPESS--FNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQR  307
            ++  LA M   K +PE+    +DEN+R  +     AG  TTS  L++ L  ++ +P V +
Sbjct  230  SDDLLAHMLNGK-DPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQ  288

Query  308  RVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRDIEVQGFRI  367
            +  +E   V+     P       + Y   V++E  R     P    +     +    + +
Sbjct  289  KAAEEAARVLVDPV-PSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPL  347

Query  368  PKGTTLITNLSSVLKDEAVW-EKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPL  426
             KG  L+  +  + +D+ +W +    F PE F +     +   AF PF  G+RAC+G+  
Sbjct  348  EKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSA--IPQHAFKPFGNGQRACIGQQF  405

Query  427  ARMELFLFFTSLLQHFSFSVPTG  449
            A  E  L    +L+HF F   T 
Sbjct  406  ALHEATLVLGMMLKHFDFEDHTN  428

Hit Number: 96, Accession Number: 4HGF_A
pdb|4HGF|A Chain A, Bifunctional P-450/NADPH-P450 reductase [Priestia megaterium]
Length = 455, Score = 69.7 bits (169), Expect = 5e-12,
Identities = 53/203 (26%), Positives = 90/203 (44%), Gaps = 7/203 (3%)
Query  250  TEAFLAEMEKAKGNPESS--FNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQR  307
            ++  LA M   K +PE+    +DEN+R  +     AG  TTS  L++ L  ++ +P V +
Sbjct  230  SDDLLAHMLNGK-DPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQ  288

Query  308  RVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRDIEVQGFRI  367
            +  +E   V+     P       + Y   V++E  R     P    +     +    + +
Sbjct  289  KAAEEAARVLVDPV-PSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPL  347

Query  368  PKGTTLITNLSSVLKDEAVW-EKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPL  426
             KG  L+  +  + +D+ +W +    F PE F +     +   AF PF  G+RAC+G+  
Sbjct  348  EKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSA--IPQHAFKPFGNGQRACIGQQF  405

Query  427  ARMELFLFFTSLLQHFSFSVPTG  449
            A  E  L    +L+HF F   T 
Sbjct  406  ALHEATLVLGMMLKHFDFEDHTN  428

Hit Number: 97, Accession Number: 4HGH_A
pdb|4HGH|A Chain A, Bifunctional P-450/NADPH-P450 reductase [Priestia megaterium]
Length = 455, Score = 69.7 bits (169), Expect = 5e-12,
Identities = 53/203 (26%), Positives = 90/203 (44%), Gaps = 7/203 (3%)
Query  250  TEAFLAEMEKAKGNPESS--FNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQR  307
            ++  LA M   K +PE+    +DEN+R  +     AG  TTS  L++ L  ++ +P V +
Sbjct  230  SDDLLAHMLNGK-DPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQ  288

Query  308  RVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRDIEVQGFRI  367
            +  +E   V+     P       + Y   V++E  R     P    +     +    + +
Sbjct  289  KAAEEAARVLVDPV-PSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPL  347

Query  368  PKGTTLITNLSSVLKDEAVW-EKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPL  426
             KG  L+  +  + +D+ +W +    F PE F +     +   AF PF  G+RAC+G+  
Sbjct  348  EKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSA--IPQHAFKPFGNGQRACIGQQF  405

Query  427  ARMELFLFFTSLLQHFSFSVPTG  449
            A  E  L    +L+HF F   T 
Sbjct  406  ALHEATLVLGMMLKHFDFEDHTN  428

Hit Number: 98, Accession Number: 1FAG_A
pdb|1FAG|A Chain A, CYTOCHROME P450 BM-3 [Priestia megaterium]
Length = 471, Score = 69.3 bits (168), Expect = 5e-12,
Identities = 59/233 (25%), Positives = 96/233 (41%), Gaps = 24/233 (10%)
Query  214  LAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENL  273
            L  K++  +KA   Q D+LLT      DP                   G P    +DEN+
Sbjct  215  LVDKIIADRKASGEQSDDLLTHMLNGKDPET-----------------GEP---LDDENI  254

Query  274  RIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPY  333
            R  +     AG  TTS  L++ L  ++ +P V ++  +E   V+     P       + Y
Sbjct  255  RYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPV-PSYKQVKQLKY  313

Query  334  TTAVIHEVQRFGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFR  392
               V++E  R     P    +     +    + + KG  L+  +  + +D+ +W +    
Sbjct  314  VGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEE  373

Query  393  FHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFS  445
            F PE F +     +   AF PF  G+RAC+G+  A  E  L    +L+HF F 
Sbjct  374  FRPERFENPSA--IPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFE  424

Hit Number: 99, Accession Number: 9L7V_A
pdb|9L7V|A Chain A, Bifunctional cytochrome P450/NADPH--P450 reductase [Priestia megaterium]
Length = 456, Score = 69.3 bits (168), Expect = 5e-12,
Identities = 60/237 (25%), Positives = 97/237 (41%), Gaps = 24/237 (10%)
Query  214  LAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENL  273
            L  K++  +KA   Q D+LLT      DP                   G P    +DEN+
Sbjct  216  LVDKIIADRKASGEQSDDLLTHMLNGKDPE-----------------TGEP---LDDENI  255

Query  274  RIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPY  333
            R  +     AG  TTS  L++ L  ++ +P V ++  +E   V+     P       + Y
Sbjct  256  RYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPV-PSYKQVKQLKY  314

Query  334  TTAVIHEVQRFGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFR  392
               V++E  R     P    +     +    + + KG  L+  +  + +D+ +W +    
Sbjct  315  VGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEE  374

Query  393  FHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG  449
            F PE F +     +   AF PF  G+RAC+G+  A  E  L    +L+HF F   T 
Sbjct  375  FRPERFENPSA--IPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTN  429

Hit Number: 100, Accession Number: 5OG9_A
pdb|5OG9|A Chain A, Bifunctional cytochrome P450/NADPH--P450 reductase [Priestia megaterium]
Length = 473, Score = 69.3 bits (168), Expect = 5e-12,
Identities = 60/237 (25%), Positives = 97/237 (41%), Gaps = 24/237 (10%)
Query  214  LAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENL  273
            L  K++  +KA   Q D+LLT      DP                   G P    +DEN+
Sbjct  215  LVDKIIADRKASGEQSDDLLTHMLNGKDPET-----------------GEP---LDDENI  254

Query  274  RIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPY  333
            R  +     AG  TTS  L++ L  ++ +P V ++  +E   V+     P       + Y
Sbjct  255  RYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPV-PSYKQVKQLKY  313

Query  334  TTAVIHEVQRFGDIVPLGMTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVW-EKPFR  392
               V++E  R     P    +     +    + + KG  L+  +  + +D+ +W +    
Sbjct  314  VGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEE  373

Query  393  FHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTG  449
            F PE F +     +   AF PF  G+RAC+G+  A  E  L    +L+HF F   T 
Sbjct  374  FRPERFENPSA--IPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTN  428