Accession Number: pdtdbl00014

Details of the Ligand

Ligand Name : Vitamin B12
Systematic Names : Cobalamin; Cyanocobalamin; Vitamin B12
Molecular Formula : C63H88CoN14O14P
Molecular Weight : g/mol
IUPAC Name : cobalt(3+);[(2R,3S,4R,5S)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] 1-[3-[(5Z,10Z,15Z)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7,12,17-tetrahydro-1H-corrin-24-id-3-yl]propanoylamino]propan-2-yl phosphate;cyanide
Canonical SMILES : CC1=CC2=C(C=C1C)N(C=N2)C3C(C(C(O3)CO)OP(=O)([O-])OC(C)CNC(=O)CCC4(C(C5C6(C(C(C(=C(C7=NC(=CC8=NC(=C(C4=N5)C)C(C8(C)C)CCC(=O)N)C(C7(C)CC(=O)N)CCC(=O)N)C)[N-]6)CCC(=O)N)(C)CC(=O)N)C)CC(=O)N)C)O.[C-]#N.[Co+3]
Ligand Description :

Vitamin B12 can be found in foods such as meat, fish, and dairy products. It can also be made in a laboratory.

Vitamin B12 is used for treating and preventing vitamin B12 deficiency, a condition in which vitamin B12 levels in the blood are too low. It is also used to treat pernicious anemia, a serious type of anemia that is due to vitamin B12 deficiency and is found mostly in older people. For this purpose, people use either a supplement that is taken by mouth or a gel that is applied inside the nose.

Vitamin B12 is also used for memory loss; Alzheimer’s disease; boosting mood, energy, concentration and the immune system; and slowing aging. It is also used for heart disease, lowering high homocysteine levels (which may contribute to heart disease), male infertility, diabetes, sleep disorders, depression, mental disorders, weak bones (osteoporosis), swollen tendons, AIDS, inflammatory bowel disease, asthma, allergies, a skin disease called vitiligo, preventing cervical and other cancers, and skin infections.

Some people use Vitamin B12 for amyotrophic lateral sclerosis (Lou Gehrig’s disease), multiple sclerosis, preventing the eye disease age-related macular degeneration (AMD), Lyme disease and gum disease. It is also used for ringing in the ears, bleeding, liver and kidney disease, and for protection against the poisons and allergens in tobacco smoke.

Vitamin B12 is applied to the skin either alone or in combination with avocado oil for psoriasis and eczema.

Vitamin B12 is frequently used in combination with other B vitamins in various vitamin B complex products.

Related Plants :
Ligand Related Dockings :
NA
Ligand References :
  1. https://en.wikipedia.org/wiki/Vitamin_B12
  2. http://www.chemspider.com/Chemical-Structure.10469504.html
  3. https://pubchem.ncbi.nlm.nih.gov/compound/5479203
  4. http://chem.sis.nlm.nih.gov/chemidplus/name/vitamin%20b12
  5. http://www.webmd.com/vitamins-supplements/ingredientmono-926-vitamin%20b12.aspx?activeingredientid=926&activeingredientname=vitamin%20b12
Vitamin B12

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