The Guaijaverin (Gua) is a polyphenolic substance which exhibits some pharmacological activities such as antibacterial and antioxidant activities. Guaijaverin from leaves of guava has potential as an antiplaque agent due to its bacteriostatic property by inhibiting the growth of S. mutans and Staphylococcus aureus (S. aureus). Guaijaverin decreases the hydrophobicity, one of the most important initial factors for the oral pathogenic bacteria to adhere to the tooth surface. This action is possibly because guava extracts binds to the cell surface proteins reducing the overall cell hydrophobicity and hence guava may have potential for development as a natural antiplaque agent.

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