Accession Number: pdtdbl00116

Details of the Ligand

Ligand Name : Rosmarinic acid
Systematic Names : Rosmarinic acid; Rosemary acid; Rosmarinate; (R)-rosmarinic acid
Molecular Formula : C18H16O8
Molecular Weight : g/mol
IUPAC Name : 3-(3,4-dihydroxyphenyl)-2-[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxypropanoic acid
Canonical SMILES : C1=CC(=C(C=C1CC(C(=O)O)OC(=O)C=CC2=CC(=C(C=C2)O)O)O)O
Ligand Description :

Rosmarinic acid is a chemical compound found in a variety of plants. It has antioxidant properties. Rosmarinic acid is a potential anxiolytic as it acts as a GABA transaminase inhibitor, more specifically on 4-aminobutyrate transaminase. Rosmarinic acid also inhibits the expression of indoleamine 2,3-dioxygenase via its cyclooxygenase-inhibiting properties.

It is found most notably in many Lamiaceae (dicotyledons in the order Lamiales), especially in the subfamily Nepetoideae. It is found in species used commonly as culinary herbs such as Ocimum basilicum (basil), Ocimum tenuiflorum (holy basil), Melissa officinalis (lemon balm), Rosmarinus officinalis (rosemary), Origanum majorana (marjoram), Salvia officinalis (sage), thyme and peppermint or in plants with medicinal properties such as common self-heal (Prunella vulgaris) or species in the genus Stachys.

Related Plants :
Ligand Related Dockings :
NA
Ligand References :
  1. https://en.wikipedia.org/wiki/Rosmarinic_acid
  2. https://pubchem.ncbi.nlm.nih.gov/compound/5281792
Rosmarinic acid

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