Accession Number: pdtdbl00127

Details of the Ligand

Ligand Name : Menthol
Systematic Names : Menthol; L-Menthol; (-)-Menthol; Levomenthol; L-(-)-Menthol; Peppermint camphor
Molecular Formula : C10H20O
Molecular Weight : g/mol
IUPAC Name : (1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexan-1-ol
Canonical SMILES : CC1CCC(C(C1)O)C(C)C
Ligand Description :

Menthol is an organic compound made synthetically or obtained from corn mint, peppermint or other mint oils. It is a waxy, crystalline substance, clear or white in color, which is solid at room temperature and melts slightly above. Menthol has local anesthetic and counterirritant qualities, and it is widely used to relieve minor throat irritation. Menthol also acts as a weak κ-opioid receptor agonist.

Menthol's ability to chemically trigger the cold-sensitive TRPM8 receptors in the skin is responsible for the well-known cooling sensation it provokes when inhaled, eaten, or applied to the skin. In this sense, it is similar to capsaicin, the chemical responsible for the spiciness of hot chilis (which stimulates heat sensors, also without causing an actual change in temperature).

Menthol's analgesic properties are mediated through a selective activation of κ-opioid receptors. Menthol also blocks voltage-sensitive sodium channels, reducing neural activity that may stimulate muscles. A study showed that topical absorption of ibuprofen is not increased by menthol, but does note the complementary effect of the menthol as a pain reliever itself.

Menthol is widely used in dental care as a topical antibacterial agent, effective against several types of streptococci and lactobacilli.

Related Plants :
Ligand Related Dockings :
NA
Ligand References :
  1. https://en.wikipedia.org/wiki/Menthol
  2. https://pubchem.ncbi.nlm.nih.gov/compound/16666
  3. http://chem.sis.nlm.nih.gov/chemidplus/rn/1490-04-6
Menthol

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