| Ligand Name : |
beta-Amyrin |
| Systematic Names : |
beta-Amyrin; Amyrin; beta-Amyrenol; Olean-12-en-3beta-ol; beta-Amyrine; beta-Amirin; beta-Amyrenol; b-Amyrenol; Olean-12-en-3beta-ol; (3beta)-Olean-12-en-3-ol |
| Molecular Formula : |
C30H50O |
| Molecular Weight : |
g/mol |
| IUPAC Name : |
(3S,4aR,6aR,6bS,8aR,12aR,14aR,14bR)-4,4,6a,6b,8a,11,11,14b-octamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-ol |
| Canonical SMILES : |
CC1(CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(C5(C)C)O)C)C)C2C1)C)C)C |
| Ligand Description : |
α-Amyrin is a precursor of Ursolic acid that is obtained by converting the CH3 in 28 to COOH. β-Amyrin is a precursor of Boswellic acid that is obtained by converting the CH3 in 24 to COOH. Ursolic acid has anti elastase activity, and like cholesterol, modulates the membrane fluidity. It prevents UV-B irradiation damages to the skin through prevention of lipid peroxidation and PGE2 release inhibition. Boswellic acid is a strong 5-lipoxigenase inhibitor and it has also anti elastase and anti GAGase properties. Alpha Amyrin has strong anti-inflammatory activity, is a pKa inhibitor as well as a selective protease inhibitor: chymotrypsin is inhibited at an 18-micromolar level.
Amyrins are abundant naturally occurring two isomeric pentacyclic triterpenes. α-Amyrin has the 29-carbon at the 20 position. β-Amyrin has the 29-carbon shifted to the 19 position. Amyrins occur mostly as acetate in latex of rubber trees. They are considered they have broad-spectrum analgesic properties. |
| Related Plants : |
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| Ligand Related Dockings : |
NA |
| Ligand References : |
- https://pubchem.ncbi.nlm.nih.gov/compound/beta-Amyrin
- http://chemicalland21.com/lifescience/uh/beta-AMYRIN.htm
- http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:10352
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