Accession Number: pdtdbl00101

Details of the Ligand

Ligand Name : Vasicine
Systematic Names : Peganine; Vasicine; 1,2,3,9-tetrahydropyrrolo[2,1-b]quinazolin-3-ol
Molecular Formula : C11H12N2O
Molecular Weight : g/mol
IUPAC Name : 1,2,3,9-tetrahydropyrrolo[2,1-b]quinazolin-3-ol
Canonical SMILES : C1CN2CC3=CC=CC=C3N=C2C1O
Ligand Description :
Vasicine (peganine) is a quinazoline alkaloid. It is the active compound of Justicia adhatoda, after which the chemical is named. Vasicine has been compared to theophylline both in vitro and in vivo. It has also been studied in combination with the related alkaloid vasicinone. Both the alkaloids in combination (1:1) showed pronounced bronchodilatory activity in vivo and in vitro. Both alkaloids are also respiratory stimulants. Vasicine has a cardiac–depressant effect, while vasicinone is a weak cardiac stimulant; the effect can be normalized by combining the alkaloids. Vasicine is reported to have a uterine stimulant effect.
Related Plants :
Adhatoda
Ligand Related Dockings :
NA
Ligand References :
  1. https://en.wikipedia.org/wiki/Vasicine
  2. https://pubchem.ncbi.nlm.nih.gov/compound/72610
  3. http://chem.sis.nlm.nih.gov/chemidplus/name/vasicine
Vasicine

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