Accession Number: pdtdbl00102

Details of the Ligand

Ligand Name : Vasicinone
Systematic Names : Vasicinone
Molecular Formula : C11H10N2O2
Molecular Weight : g/mol
IUPAC Name : (3S)-3-hydroxy-2,3-dihydro-1H-pyrrolo[2,1-b]quinazolin-9-one
Canonical SMILES : C1CN2C(=NC3=CC=CC=C3C2=O)C1O
Ligand Description :

Vasicinone is a quinazoline alkaloid. It shows bronchodilatory activity in vitro but bronchoconstrictory activity in vivo. Vasicinone was shown to have an antianaphylactic action.

Vasicinone has also been studied in combination with the related alkaloid vasicine. Both the alkaloids in combination (1:1) showed pronounced bronchodilatory activity in vivo and in vitro. Both alkaloids are also respiratory stimulants. Vasicine has a cardiac-depressant effect, while vasicinone is a weak cardiac stimulant; the effect can be normalized by combining the alkaloids. Vasicine is reported to have a uterine stimulant effect.
Related Plants :
Adhatoda
Ligand Related Dockings :
NA
Ligand References :
  1. https://en.wikipedia.org/wiki/Vasicinone
  2. https://pubchem.ncbi.nlm.nih.gov/compound/442935
  3. http://chem.sis.nlm.nih.gov/chemidplus/name/vasicinone
Vasicinone

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