Accession Number: pdtdbl00205

Details of the Ligand

Ligand Name : Piperlongumine
Systematic Names : Piperlongumine; Piplartine; (E)-5,6-Dihydro-1-[1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl]-2(1H)-pyridinone
Molecular Formula : C17H19NO5
Molecular Weight : g/mol
IUPAC Name : 1-[(E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]-2,3-dihydropyridin-6-one
Canonical SMILES : COC1=CC(=CC(=C1OC)OC)C=CC(=O)N2CCC=CC2=O
Ligand Description :

Piperlongumine (PL) is a natural product constituent of the fruit of the Long pepper (Piper longum), a pepper plant found in southern India and southeast Asia.

Piperlongumine may have anti-cancer properties. In in vitro experiments, it selectively kills some types cancer cells over normal cells. One study in a xenograft mouse model of cancer showed that piperlongumine inhibits the growth of malignant breast tumors and their associated metastases.
Related Plants :
Long Pepper
Ligand Related Dockings :
NA
Ligand References :
  1. https://en.wikipedia.org/wiki/Piperlongumine
  2. https://pubchem.ncbi.nlm.nih.gov/compound/637858
  3. http://www.hindawi.com/journals/omcl/2014/906804/
  4. http://chem.sis.nlm.nih.gov/chemidplus/name/piperlongumine
Piperlongumine

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